NEK1 - Nek1 NIMA-related kinase 1 Gene

种属: Rattus norvegicus

关于 NEK1

功能概要

Predicted to enable 14-3-3 protein binding activity and protein serine/threonine kinase activity. Predicted to be involved in cilium assembly; protein phosphorylation; and regulation of DNA damage checkpoint. Predicted to act upstream of or within several processes, including cellular response to DNA damage stimulus; response to ionizing radiation; and spermatogenesis. Predicted to be located in centrosome; cytosol; and nucleoplasm. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis; asphyxiating thoracic dystrophy; and short-rib thoracic dysplasia 6 with or without polydactyly. Orthologous to human NEK1 (NIMA related kinase 1). [provided by Alliance of Genome Resources, Apr 2022]