RANGRF - RAN guanine nucleotide release factor Gene

中文名称：RAN 鸟嘌呤核苷酸释放因子

种属: Homo sapiens

同用名: MOG1; HSPC165; HSPC236; RANGNRF

基因 ID: 29098 | 基因类型: protein coding

关于 RANGRF

Cytogenetic location: 17p13.1 Genomic coordinates (GRCh38): 17:8,288,670-8,290,087 (from NCBI)

This gene has 6 transcripts (splice variants), 176 orthologues and is associated with 1 phenotype. Broad expression in testis (RPKM 13.3), endometrium (RPKM 7.1) and 24 other tissues.

功能概要

该基因编码的蛋白质已被证明在小鼠中起鸟嘌呤核苷酸释放因子的作用，并可调节人类 Nav1.5 心脏钠通道的表达和功能。可变剪接导致多个转录本变体。[RefSeq 提供，2010 年 4 月]

This gene encodes a protein that has been shown to function as a guanine nucleotide release factor in mouse and to regulate the expression and function of the Nav1.5 cardiac Sodium Channel in human. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2010]

RANGRF 基因产物(4)

mRNA	Protein	Name
NM_001177801.2	NP_001171272.1	ran guanine nucleotide release factor isoform B
NM_001177802.2	NP_001171273.1	ran guanine nucleotide release factor isoform C
NM_001330127.2	NP_001317056.1	ran guanine nucleotide release factor isoform D
NM_016492.5	NP_057576.2	ran guanine nucleotide release factor isoform A

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	28514442	GOA
enables small GTPase binding	IPI IPI: 通过物理相互作用推断	11290418	GOA
enables sodium channel regulator activity	IDA IDA: 通过直接分析推断	18184654	GOA
enables sodium channel regulator activity	IMP IMP: 通过突变表型推断	23420830	GOA
enables transmembrane transporter binding	IPI IPI: 通过物理相互作用推断	18184654	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in endoplasmic reticulum to Golgi vesicle-mediated transport	IMP IMP: 通过突变表型推断	23420830	GOA
involved in mitotic spindle assembly	IMP IMP: 通过突变表型推断	29040603	GOA
involved in positive regulation of protein localization to cell surface	IDA IDA: 通过直接分析推断	18184654	GOA
involved in positive regulation of protein localization to cell surface	IMP IMP: 通过突变表型推断	23420830	GOA
involved in positive regulation of protein localization to plasma membrane	IMP IMP: 通过突变表型推断	23420830	GOA
involved in protein exit from endoplasmic reticulum	IMP IMP: 通过突变表型推断	23420830	GOA
involved in regulation of bundle of His cell action potential	IMP IMP: 通过突变表型推断	21621375	GOA
involved in regulation of cardiac muscle cell action potential involved in regulation of contraction	IMP IMP: 通过突变表型推断	21621375	GOA
involved in regulation of membrane depolarization	IDA IDA: 通过直接分析推断	18184654	GOA
involved in regulation of membrane depolarization	IMP IMP: 通过突变表型推断	23420830	GOA
involved in regulation of membrane depolarization during cardiac muscle cell action potential	IMP IMP: 通过突变表型推断	21621375	GOA
involved in regulation of membrane potential	IDA IDA: 通过直接分析推断	18184654	GOA
involved in regulation of sodium ion transmembrane transport	IDA IDA: 通过直接分析推断	18184654	GOA
involved in regulation of sodium ion transmembrane transport	IMP IMP: 通过突变表型推断	21621375	GOA
involved in regulation of sodium ion transmembrane transporter activity	IDA IDA: 通过直接分析推断	18184654	GOA
involved in regulation of sodium ion transmembrane transporter activity	IMP IMP: 通过突变表型推断	21621375	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in caveola	IDA IDA: 通过直接分析推断	23420830	GOA
located in cytoplasm	IDA IDA: 通过直接分析推断	11290418	GOA
located in nucleus	IDA IDA: 通过直接分析推断	11290418	GOA
located in rough endoplasmic reticulum	IDA IDA: 通过直接分析推断	23420830	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

RANGRF 蛋白结构

Mog1

0
100
186 a.a.

蛋白主名

其他名称

ran guanine nucleotide release factor

MOG1 homolog

关联疾病

疾病名称

别名

Brugada Syndrome

Sudden Unexpected Nocturnal Death Syndrome	Sudden Unexplained Nocturnal Death Syndrome
Bangungut	Brugada Type Idiopathic Ventricular Fibrillation
Pokkuri Death Syndrome	Sunds
Idiopathic Ventricular Fibrillation, Brugada Type	Sudden Unexplained Death
Dream Disease	Right Bundle Branch Block, St Segment Elevation, And Sudden Death Syndrome
Sudden Unexplained Death Syndrome	Suds
Sunds - [Sudden Unexplained Nocturnal Death Syndrome]

Sick Sinus Syndrome

Sinus Node Dysfunction	Sinus Node Disease
Sinus Node Infection	Snd
Sss	Snd - [Sinus Node Dysfunction]
Sinoatrial Node Dysfunction	Sss - [Sick Sinus Syndrome]
Sick Sinus	Sick Sinus Tachycardia

Sinoatrial Node Disease

Sa Node	Sinuatrial Node
Sinus Node Dysfunction

Right Bundle Branch Block

Right Bundle Branch Block With Left Posterior Fascicular Block

Long Qt Syndrome 2

LQT2	Long Qt Syndrome, Acquired, Reduced Susceptibility To
Long Qt Syndrome 1/2	Long Qt Syndrome 2/3
Long Qt Syndrome 2/5	Long Qt Syndrome 2, Acquired, Susceptibility To
Long Qt Syndrome, Acquired, Reduced	Long Qt Syndrome Type 2
Long Qt Syndrome 2/9	Lqt1/2
Lqt2/3	Lqt2/5
Lqt2/9	Susceptibility To Acquired Long Qt Syndrome 2
Long Qt Syndrome-2	Qt Syndrome, Long, Type 2
Long Qt Syndrome 1-2	Long Qt Syndrome 2-3
Long Qt Syndrome 2-5	Long Qt Syndrome 9

Catecholaminergic Polymorphic Ventricular Tachycardia

Cpvt	Catecholamine-Induced Polymorphic Ventricular Tachycardia
Familial Polymorphic Ventricular Tachycardia	Malignant Paroxysmal Ventricular Tachycardia
Multifocal Ventricular Premature Beats	Stress-Induced Polymorphic Ventricular Tachycardia
Bidirectional Tachycardia Induced By Catecholamine	Double Tachycardia Induced By Catecholamines
Polymorphic Catecholergic Ventricular Tachycardia	Syncopal Paroxysmal Tachycardia
Bidirectional Tachycardia Induced By Catecholamines	Fpvt
Bidirectional Ventricular Tachycardia Induced By Catecholamine	Polymorphic Ventricular Tachycardia Induced By Catecholamines
Ventricular Tachycardia, Catecholaminergic Polymorphic	Ventricular Tachycardia, Catecholaminergic Polymorphic, 1
Familial Ventricular Tachycardia	Multifocal Pvcs
Multifocal Premature Ventricular Beats

Long Qt Syndrome 1

Romano-Ward Syndrome	LQT1
Ward-Romano Syndrome	Rws
Ventricular Fibrillation With Prolonged Qt Interval	Wrs
Long Qt Syndrome 1, Acquired, Susceptibility To	Long Qt Syndrome 1, Acquired
Romano-Ward Long Qt Syndrome	Long Qt Syndrome Type 1
Long Qt Syndrome-1	Acquired Susceptibility To Long Qt Syndrome 1
Qt Syndrome, Long, Type 1

Long Qt Syndrome

Romano-Ward Syndrome	Long Q-T Syndrome
Lqt	Qt Syndrome, Long
Congenital Long Qt Syndrome	Familial Long Qt Syndrome

Familial Atrial Fibrillation

Atrial Fibrillation, Familial	Atfb
Atrial Fibrillation Autosomal Dominant	Autosomal Dominant Atrial Fibrillation
Auricular Fibrillation	Atrial Fibrillation
Atrial Fibrillation, Familial, 1

Left Ventricular Noncompaction

Noncompaction Cardiomyopathy	Left Ventricular Hypertrabeculation
Lvnc	Spongy Myocardium
Isolated Noncompaction Of The Ventricular Myocardium	Left Ventricular Myocardial Noncompaction Cardiomyopathy
Fetal Myocardium	Honeycomb Myocardium
Hypertrabeculation Syndrome	Left Ventricular Non-Compaction
Lvht	Non-Compaction Of The Left Ventricular Myocardium
Ventricular Noncompaction, Left	Non-Compaction Cardiomyopathy

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS11651	RANGRF Human Pre-designed siRNA Set A	Pre-designed Set	/	否

直系同源

种属	基因名	来源	基因 ID
Bos taurus	RANGRF	VGNC	VGNC:33714
Mus musculus	RANGRF	MGD	MGI:1889073
Macaca mulatta	RANGRF	VGNC	VGNC:76503
Canis familiaris	RANGRF	VGNC	VGNC:45341
Rattus norvegicus	RANGRF	RGD	RGD:1563195

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

RANGRF - RAN guanine nucleotide release factor Gene

关于 RANGRF

功能概要

RANGRF 基因产物(4)

RANGRF 蛋白结构

关联疾病

直系同源

热门区域

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RANGRF - RAN guanine nucleotide release factor Gene

关于 RANGRF

功能概要

RANGRF 基因产物(4)

RANGRF 蛋白结构

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z