ZDHHC8 - zinc finger DHHC-type palmitoyltransferase 8 Gene

中文名称：锌指 DHHC 型棕榈酰转移酶 8

种属: Homo sapiens

同用名: DHHC8; ZNF378; ZDHHCL1

基因 ID: 29801 | 基因类型: protein coding

关于 ZDHHC8

Cytogenetic location: 22q11.21 Genomic coordinates (GRCh38): 22:20,131,804-20,148,007 (from NCBI)

This gene has 7 transcripts (splice variants), 263 orthologues and 1 paralogue. Ubiquitous expression in fat (RPKM 6.8), spleen (RPKM 6.7) and 25 other tissues.

功能概要

该基因编码一种四跨膜蛋白，它是含锌指 DHHC 结构域的蛋白家族的成员。所编码的蛋白质可作为棕榈酰转移酶发挥作用。该基因的缺陷可能与精神分裂症的易感性有关。该基因的交替剪接导致多个转录变体。在 22 号染色体上发现了该基因的假基因。[RefSeq 提供，2010 年 5 月]

This gene encodes a four transmembrane protein that is a member of the zinc finger DHHC domain-containing protein family. The encoded protein may function as a palmitoyltransferase. Defects in this gene may be associated with a susceptibility to schizophrenia. Alternate splicing of this gene results in multiple transcript variants. A pseudogene of this gene is found on chromosome 22.[provided by RefSeq, May 2010]

ZDHHC8 基因产物(2)

mRNA	Protein	Name
NM_001185024.2	NP_001171953.1	palmitoyltransferase ZDHHC8 isoform 1
NM_013373.4	NP_037505.1	palmitoyltransferase ZDHHC8 isoform 2

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables palmitoyltransferase activity	IDA IDA: 通过直接分析推断	23034182	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in peptidyl-L-cysteine S-palmitoylation	IDA IDA: 通过直接分析推断	19556522	GOA
involved in positive regulation by host of viral process	IDA IDA: 通过直接分析推断	34599882	GOA
involved in positive regulation of cholesterol efflux	IDA IDA: 通过直接分析推断	19556522	GOA
involved in protein palmitoylation	IDA IDA: 通过直接分析推断	23034182	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in Golgi apparatus	IDA IDA: 通过直接分析推断	16647879	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ZDHHC8 蛋白结构

DHHC

0
200
400
600
765 a.a.

蛋白主名

其他名称

palmitoyltransferase ZDHHC8

membrane-associated DHHC8 zinc finger protein

关联疾病

疾病名称

别名

Schizophrenia

SCZD	Schizophrenia With Or Without An Affective Disorder
Schizophrenia 12	Schizophrenia, Susceptibility To
Schizophrenia-1	Dementia Praecox
Schizophrenia 1

Chromosome 6q24-Q25 Deletion Syndrome

Chromosome 6q25-Q25 Deletion Syndrome	6q25 Microdeletion Syndrome
Monosomy 6q25	Del(6)(Q25)

Chromosome 22q11.2 Deletion Syndrome, Distal

22q11.2 Deletion Syndrome	Autosomal Dominant Opitz G/Bbb Syndrome
Catch22	Cayler Cardiofacial Syndrome
Conotruncal Anomaly Face Syndrome	Digeorge Syndrome
Sedlackova Syndrome	Shprintzen Syndrome
Velocardiofacial Syndrome	22q11.2 Distal Deletion Syndrome
Distal 22q11.2 Microdeletion Syndrome	22q11.2ds
Vcfs	Velo-Cardio-Facial Syndrome
Distal Chromosome 22q11.2 Deletion Syndrome	Chromosome 22q11.2 Deletion Syndrome Distal
Chromosome 22q11.2 Deletion Syndrome	Deletion 22q11.2 Syndrome
22q11ds	Catch 22
Digeorge Sequence	Microdeletion 22q11.2
Monosomy 22q11	Takao Syndrome
Distal Del(22)(Q11.2)	Distal Monosomy 22q11.2
Catch 22 Syndrome	Chromosome Deletion Syndrome 22q11.2, Distal

Velocardiofacial Syndrome

Shprintzen Syndrome	VCFS
Chromosome 22q11.2 Deletion Syndrome	Vcf Syndrome
Shprintzen Vcf Syndrome	Vcf-Velocardiofacial Syndrome
Velo-Cardio-Facial Syndrome	Digeorge Syndrome
22q11 Deletion Syndrome	Conotruncal Anomaly Face Syndrome

T-Cell Immunodeficiency With Thymic Aplasia

Nezelof Syndrome	T-Lymphocyte Deficiency
TIDTA	Immune Defect Due To Absence Of Thymus
Thymic Aplasia	Nezelof'S Syndrome
Thymic Dysplasia With Normal Immunoglobulins	Thymic Aplasia Syndrome
T-Lymphocyte Immunodeficiency

Chromosome 15q13.3 Deletion Syndrome

Chromosome 15q13.3 Microdeletion Syndrome	15q13.3 Microdeletion Syndrome
15q13.3 Microdeletion	Microdeletion 15q13.3 Syndrome
Del(15)(Q13.3)	Monosomy 15q13.3

Chromosomal Deletion Syndrome

Psychotic Disorder

Psychotic Disorders	Mental Or Behavioural Disorder
Psychotic	Mental Disorders

Neuronal Ceroid Lipofuscinosis

Hereditary Ceroid Lipofuscinosis	Batten Disease
Ncl	Neuronal Ceroid-Lipofuscinoses
Lipofuscinosis, Ceroid, Neuronal	Juvenile Neuronal Ceroid Lipofuscinosis
Cerebromacular Dystrophy	Cerebromacular Degeneration
Ceroid-Lipofuscinosis	Ncl - [Neuronal Ceroid Lipofuscinosis]
Amaurotic Familial Idiocy	Amaurotic Idiocy
Amaurotic Idiot	Neuronal Lipofuscinosis
Pigmentary Retinal Lipoid Neuronal Heredodegeneration

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS16023	ZDHHC8 Human Pre-designed siRNA Set A	Pre-designed Set	/	否

直系同源

种属	基因名	来源	基因 ID
Felis catus	ZDHHC8	VGNC	VGNC:67219
Macaca mulatta	ZDHHC8	VGNC	VGNC:79146
Mus musculus	ZDHHC8	MGD	MGI:1338012
Rattus norvegicus	ZDHHC8	RGD	RGD:1308875
Canis familiaris	ZDHHC8	VGNC	VGNC:48594
Bos taurus	ZDHHC8	VGNC	VGNC:58428

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