2. Gene
  3. Tiam1 - TIAM Rac1 associated GEF 1 Gene

Tiam1 - TIAM Rac1 associated GEF 1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

基因 ID: 304109 | 基因类型: protein coding

关于 Tiam1

功能概要

Enables microtubule binding activity and receptor tyrosine kinase binding activity. Involved in several processes, including NMDA selective glutamate receptor signaling pathway; generation of neurons; and regulation of MAPK cascade. Located in several cellular components, including axon; postsynaptic density; and ruffle membrane. Is active in glutamatergic synapse. Is extrinsic component of postsynaptic density membrane. Colocalizes with microtubule. Orthologous to human TIAM1 (TIAM Rac1 associated GEF 1). [provided by Alliance of Genome Resources, Apr 2022]

Tiam1 基因产物(1)

mRNA Protein Name
NM_001100558.2 NP_001094028.1 T-lymphoma invasion and metastasis-inducing protein 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables microtubule binding IDA
IDA: 通过直接分析推断
11264310 RGD
enables protein binding IPI
IPI: 通过物理相互作用推断
12446731 RGD
enables receptor tyrosine kinase binding IPI
IPI: 通过物理相互作用推断
16801538 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in activation of GTPase activity IMP
IMP: 通过突变表型推断
18930714 RGD
involved in cardiac muscle hypertrophy IMP
IMP: 通过突变表型推断
22564263 RGD
involved in neuron projection extension IMP
IMP: 通过突变表型推断
20333299 RGD
involved in positive regulation of JUN kinase activity IMP
IMP: 通过突变表型推断
16203995 RGD
involved in positive regulation of Schwann cell chemotaxis IMP
IMP: 通过突变表型推断
16203995 RGD
involved in positive regulation of axonogenesis IMP
IMP: 通过突变表型推断
11264310 RGD
involved in positive regulation of cell migration IMP
IMP: 通过突变表型推断
24123220 RGD
involved in positive regulation of dendritic spine morphogenesis IMP
IMP: 通过突变表型推断
16474385 RGD
involved in positive regulation of neuron projection development IMP
IMP: 通过突变表型推断
20333299 RGD
involved in protein localization to membrane IMP
IMP: 通过突变表型推断
18930714 RGD
involved in regulation of ERK1 and ERK2 cascade IMP
IMP: 通过突变表型推断
22564263 RGD
involved in regulation of insulin secretion involved in cellular response to glucose stimulus IMP
IMP: 通过突变表型推断
18930714 RGD
involved in regulation of modification of postsynaptic actin cytoskeleton IDA
IDA: 通过直接分析推断
15721239 RGD
involved in regulation of modification of postsynaptic actin cytoskeleton IMP
IMP: 通过突变表型推断
15721239 RGD
involved in regulation of postsynapse organization IDA
IDA: 通过直接分析推断
15721239 RGD
involved in regulation of postsynapse organization IMP
IMP: 通过突变表型推断
15721239 RGD
involved in response to cocaine IEP
IEP: 通过表达模式推断
23745104 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in axonal growth cone IDA
IDA: 通过直接分析推断
11264310 RGD
located in dendritic spine IDA
IDA: 通过直接分析推断
16474385 RGD
is active in extrinsic component of postsynaptic density membrane IDA
IDA: 通过直接分析推断
15721239 RGD
is active in glutamatergic synapse IDA
IDA: 通过直接分析推断
15721239 RGD
is active in glutamatergic synapse IMP
IMP: 通过突变表型推断
15721239 RGD
located in main axon IDA
IDA: 通过直接分析推断
11264310 RGD
located in microtubule IDA
IDA: 通过直接分析推断
11264310 RGD
located in neuronal cell body IDA
IDA: 通过直接分析推断
11264310 RGD
located in ruffle membrane IDA
IDA: 通过直接分析推断
12446731 RGD
located in somatodendritic compartment IDA
IDA: 通过直接分析推断
23300879 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

T-lymphoma invasion and metastasis-inducing protein 1

T-cell lymphoma invasion and metastasis 1

相关产品

Pre-clinical Phase
生物活性分子 (9)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-16659 EHT 1864 Inhibitor 99.85% 否
HY-104064 1A-116 99.72% 否
HY-115376 Z62954982 Inhibitor 99.38% 否
HY-P1382A Rac1 Inhibitor W56 TFA Inhibitor 99.92% 否
HY-171977 UTKO1 / 否
HY-P1382 Rac1 Inhibitor W56 Inhibitor / 否
HY-RS14515 TIAM1 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS18300 Tiam1 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS24778 Tiam1 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Tiam1 NCBI NCBI:7074
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