Ngf - nerve growth factor Gene

种属: Rattus norvegicus

同用名: Ngfb; beta-NGF

基因 ID: 310738 | 基因类型: protein coding

关于 Ngf

功能概要

Predicted to enable nerve growth factor receptor binding activity; peptidase regulator activity; and signaling receptor activator activity. Involved in several processes, including negative regulation of apoptotic process; positive regulation of ERK1 and ERK2 cascade; and response to ozone. Acts upstream of or within positive regulation of DNA-binding transcription factor activity; positive regulation of neurotrophin Trk Receptor signaling pathway; and positive regulation of protein autophosphorylation. Located in extracellular space. Used to study bladder neck obstruction; cystitis; degenerative disc disease; and neurogenic bladder. Biomarker of several diseases, including diabetic neuropathy; hyperhomocysteinemia; mental depression; myofascial pain syndrome; and respiratory syncytial virus infectious disease. Human ortholog(s) of this gene implicated in IgA glomerulonephritis; asthma; end stage renal disease; hereditary sensory and autonomic neuropathy type 5; and interstitial cystitis. Orthologous to human NGF (nerve growth factor). [provided by Alliance of Genome Resources, Apr 2022]

Ngf 基因产物(1)

mRNA	Protein	Name
NM_001277055.1	NP_001263984.1	beta-nerve growth factor precursor

基因本体论

生物过程
细胞组分

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in adult locomotory behavior	IMP IMP: 通过突变表型推断	19129380	RGD
involved in cell population proliferation	IMP IMP: 通过突变表型推断	23934089	RGD
involved in cell proliferation in forebrain	IMP IMP: 通过突变表型推断	29409115	RGD
involved in memory	IMP IMP: 通过突变表型推断	19129380	RGD
involved in negative regulation of neuron apoptotic process	IMP IMP: 通过突变表型推断	21541365	RGD
involved in negative regulation of type B pancreatic cell apoptotic process	IMP IMP: 通过突变表型推断	22926925	RGD
involved in neuron differentiation	IMP IMP: 通过突变表型推断	23934089	RGD
involved in neuron projection development	IDA IDA: 通过直接分析推断	3336364	RGD
acts upstream of or within positive regulation of DNA-binding transcription factor activity	IDA IDA: 通过直接分析推断	19029245	RGD
involved in positive regulation of ERK1 and ERK2 cascade	IDA IDA: 通过直接分析推断	17310240	RGD
involved in positive regulation of cell growth	IDA IDA: 通过直接分析推断	18973572	RGD
involved in positive regulation of cell population proliferation	IDA IDA: 通过直接分析推断	18846328	RGD
involved in positive regulation of neuron differentiation	IDA IDA: 通过直接分析推断	18846328	RGD
acts upstream of or within positive regulation of neurotrophin TRK receptor signaling pathway	IDA IDA: 通过直接分析推断	19029245	RGD
acts upstream of or within positive regulation of protein autophosphorylation	IDA IDA: 通过直接分析推断	19029245	RGD
involved in positive regulation of protein phosphorylation	IDA IDA: 通过直接分析推断	20605787	RGD
involved in positive regulation of stem cell proliferation	IDA IDA: 通过直接分析推断	18846328	RGD
involved in response to electrical stimulus	IEP IEP: 通过表达模式推断	19059440	RGD
involved in response to glucocorticoid	IEP IEP: 通过表达模式推断	19200610	RGD
involved in response to lipopolysaccharide	IEP IEP: 通过表达模式推断	19012240	RGD
involved in response to mechanical stimulus	IEP IEP: 通过表达模式推断	18981959	RGD
involved in response to nicotine	IEP IEP: 通过表达模式推断	19824047	RGD
involved in response to organic cyclic compound	IEP IEP: 通过表达模式推断	18818126	RGD
involved in response to ozone	IEP IEP: 通过表达模式推断	21075861	RGD
involved in response to peptide hormone	IEP IEP: 通过表达模式推断	18756821	RGD
involved in response to xenobiotic stimulus	IEP IEP: 通过表达模式推断	18836171	RGD
involved in sensory perception of hot stimulus	IDA IDA: 通过直接分析推断	27392124	RGD
involved in spermatogenesis	IEP IEP: 通过表达模式推断	1315318	RGD

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in extracellular space	IDA IDA: 通过直接分析推断	19065562	RGD

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

蛋白主名

其他名称

beta-nerve growth factor

nerve growth factor (beta polypeptide)

pro-nerve growth factor long

相关产品

Approval

生物活性分子 (6)

目录号	产品名	作用方式	纯度	是否罕见病
HY-I0021	Bepotastine	Antagonist	98.58%	否
HY-A0015	Bepotastine besilate	Antagonist	99.77%	否
HY-B0446	Naphazoline hydrochloride		99.38%	否
HY-111326A	Naphazoline nitrate		99.12%	否
HY-111326	Naphazoline		99.74%	否
HY-I0021A	Bepotastine tosylate	Antagonist	/	否

抗体抑制剂 (1)

目录号	产品名	作用方式	纯度	是否罕见病
HY-P99297	Bedinvetmab	Inhibitor	99.80%	否

Clinical Phase

生物活性分子 (3)

目录号	产品名	作用方式	纯度	Phase
HY-17622	Tavilermide	Agonist	99.57%	Phase 3
HY-109194	Udonitrectag		98.46%	Phase 2
HY-120251A	Leteprinim potassium	Inhibitor	≥99.0%	Phase 2

抗体抑制剂 (3)

目录号	产品名	作用方式	纯度	Phase
HY-P99221	Tanezumab	Antagonist	99.52%	Phase 3
HY-P99195	Fasinumab	Inhibitor	98.11%	Phase 3
HY-P99200	Fulranumab	Inhibitor	96.74%	Phase 3

Pre-clinical Phase

生物活性分子 (41)

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-N6732	K-252a	Inhibitor	99.45%	否
HY-108466	Ro 08-2750	Inducer	98.63%	否
HY-18314	GW 441756		99.95%	否
HY-N6838	1,1,1,1-Kestohexaose		≥98.0%	否
HY-133968	24-Methylenecholesterol		99.48%	否
HY-N0380	Nardosinone	Activator	99.45%	否
HY-110166	PD 90780		≥99.0%	否
HY-120553	B-355252	Inhibitor	≥99.0%	否
HY-N0857	Deoxyandrographolide	Activator	99.87%	否
HY-124637	ALE-0540	Antagonist	98.24%	否
HY-P3709A	TRAF6 peptide TFA	Inhibitor	98.20%	否
HY-A0015A	(Rac)-Bepotastine besilate	Inhibitor	99.52%	否
HY-P3709	TRAF6 peptide	Inhibitor	/	否
HY-11055	KP 544		/	否
HY-116202	PACA	Activator	/	否
HY-117517	NG-012	Activator	/	否
HY-120251	Leteprinim	Inhibitor	/	否
HY-124152	3,4-Dephostatin	Inhibitor	/	否
HY-130179	RC-33 hydrochloride	Inducer	/	否
HY-133968S1	24-Methylenecholesterol-13C		/	否
HY-146523	TRK-IN-17	Inhibitor	/	否
HY-146524	TRK-IN-18	Inhibitor	/	否
HY-A0015S	Bepotastine-d6 besylate	Antagonist	/	否
HY-D2336	PROTAC Aster-A degrader-1		/	否
HY-N10325	Sarbronine M		/	否
HY-N12170	Kissoone C		/	否
HY-N12566	Erinacin B		/	否
HY-N15532	Phenylmethyl 6-O-α-L-arabinofuranosyl-β-D-glucopyranoside	Modulator	/	否
HY-N3928	Garciniaxanthone E		/	否
HY-N3938	Gelsemiol		/	否
HY-NP144	Nerve Growth Factor 7S,murine submaxillary gland		/	否
HY-P10140	JNK-IN-15, Cell-Permeable	Inhibitor	/	否
HY-P10141	JNK-IN-15, Cell-Permeable, Negative Control	Inhibitor	/	否
HY-P5156	BDS-I	Inhibitor	/	否
HY-RS09277	NGF Human Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-171450	VMD-928	Inhibitor	/	否
HY-N13170	Glycoside H2		/	否
HY-N14417	Indocarbazostatin		/	否
HY-N14424	Indocarbazostatin B		/	否
HY-RS16265	Ngf Mouse Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS22931	Ngf Rat Pre-designed siRNA Set A	Pre-designed Set	/	否

抗体抑制剂 (10)

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-P99627	Frunevetmab		95.00%	否
HY-P99825	Relfovetmab	Inhibitor	99.88%	否
HY-P990749	Luvagrobart	Inhibitor	/	否
HY-P991321	ABT-110	Inhibitor	/	否
HY-P991323	MEDI-1912	Inhibitor	/	否
HY-P991324	MEDI-7352	Inhibitor	/	否
HY-P991325	CRB-0089	Inhibitor	/	否
HY-P991622	MNAC13	Inhibitor	/	否
HY-P990474	Anti-NGF/bNGF Antibody	Inhibitor	99.65%	否
HY-P99820	Ranevetmab		/	否

直系同源

种属	基因名	来源	基因 ID
Homo sapiens	Ngf	NCBI	NCBI:4803
Mus musculus	Ngf	NCBI	NCBI:18049
Leporidae	Ngf	NCBI

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