2. Neuronal Signaling Protein Tyrosine Kinase/RTK
  3. Trk Receptor
  4. Tanezumab

Tanezumab  (Synonyms: 他尼组单抗; RN-624; PF 4383119)

目录号: HY-P99221 纯度: 99.52%
COA 技术支持

Tanezumab (RN-624) 是一种具有高亲和力和特异性的人源化抗 NGF 单克隆抗体，能阻断 NGF 与周围神经系统中的受体 p75 和 TrkA 结合。Tanezumab 可用于急性和慢性疼痛，如骨关节炎，膝关节和神经痛和带状疱疹后神经痛的研究。

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CAS No. : 880266-57-9

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5 mg ￥5250
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Tanezumab 相关抗体

Top Publications Citing Use of Products

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Tanezumab (RN-624) is a humanized anti-NGF mAb with high affinity and specificity. Tanezumab blocks NGF binding to its receptors, p75 and TrkA, in the peripheral nervous system. Tanezumab can be used in studies of acute and chronic pain such as osteoarthritis, knee and neuralgia, as well as post-herpetic neuralgia[1][2].

同型

Human IgG4 kappa
推荐同型对照抗体
反应种属

Human
IC50 & Target

NGF/bNGF
体外研究
(In Vitro)

Tanezumab (100 ng/mL, 48 h) 降低 NGF 蛋白的表达，抑制 MiaPaCa-2 和 CFPAC-1 细胞的迁移和侵袭[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Tanezumab 相关抗体:

Cell Migration Assay [3]

Cell Line: MiaPaCa-2 and CFPAC-1
Concentration: 100 ng/mL
Incubation Time: 48 h
Result: Inhibited cell migration.
体内研究
(In Vivo)

Tanezumab (10 mg/kg, sc, once a day for 8 weeks) 在 MiaPaCa-2 异种移植小鼠模型中表现出抗肿瘤活性，缓解痛觉传导[3]。
Tanezumab (2.5-5 mg/kg, sc, once a week for 4 weeks) 在大鼠大骨节病 (Kashin-Beck Disease) 模型中表现出抗炎和镇痛作用[4]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: MiaPaCa-2 xenograft mouse models[3]
Dosage: 10 mg/kg
Administration: sc, once a day for 8 weeks
Result: Reduced the tumor volume and invasive nerve diameter.
Alleviated hindlimb dysfunction.
Animal Model: Sprague-Dawley rat Kashin-Beck Disease models[4]
Dosage: 2.5-5 mg/kg
Administration: sc, once a week for 4 weeks
Result: Increased the paw withdrawal mechanical threshold (PWT) and thermal paw withdrawal latency (PWL).
Decreased serum TNF-α and IL-1β levels.
Clinical Trial
基因 ID

4803  [NCBI]

Accession
应用

ELISA, FACS, Functional assay
偶联物

Unconjugated
复溶方法

The product can be reconstituted/diluted with sterile PBS or saline.
分子量

145.44 kDa

CAS 号
性状

液体

颜色

Colorless to light yellow

中文名称

他尼组单抗
运输条件

Shipping with dry ice.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human IgG2 kappa
Biological Activity
  • Immobilized Beta-NGF Protein, Human, HEK293, HY-P7660 can bind Tanezumab. The EC50 for this effect is 5.218 ng/mL.
纯度 & 产品资料

纯度: 99.52%

COA (267 KB) SDS-PAGE (90 KB) SEC-HPLC (157 KB)

抗体抑制剂使用指南 (1152 KB)
参考文献

Tanezumab 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tanezumab880266-57-9RN-624 PF 4383119他尼组单抗RN624RN 624PF4383119PF 4383119PF-4383119Trk ReceptorTropomyosin related kinase receptorpostherpetic neuralgiaPHNacute painchronic painosteoarthritisBALB/c mouseSprague-Dawley ratMiaPaCa-2CFPAC-1Inhibitorinhibitorinhibit

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