2. Metabolic Enzyme/Protease NF-κB Immunology/Inflammation
  3. Acyltransferase Reactive Oxygen Species (ROS)
  4. 24-Methylenecholesterol

24-Methylenecholesterol  (Synonyms: Ostreasterol)

目录号: HY-133968 纯度: 99.48%
COA 产品使用指南 技术支持

24-Methylenecholesterol (Ostreasterol) 是靶向酰基辅酶 A 胆固醇酰基转移酶 (ACAT) 的调节剂，具有抗衰老和神经保护作用。24-Methylenecholesterol 模拟神经生长因子 (NGF) 的作用，可通过抗氧化应激机制延长酵母寿命，并在 PC12 细胞中表现出神经保护活性。24-Methylenecholesterol 可降低细胞内活性氧 (ROS) 和丙二醛 (MDA) 水平，激活抗氧化应激通路 (如 UTH1、SOD 相关基因)，促进神经突触生长。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

24-Methylenecholesterol Chemical Structure

24-Methylenecholesterol Chemical Structure

CAS No. : 474-63-5

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 价格 是否有货 数量
1 mg ￥1300
In-stock
5 mg ￥4000
In-stock
10 mg 现货 询价
50 mg   询价  
100 mg   询价  

* Please select Quantity before adding items.

Other Forms of 24-Methylenecholesterol:

24-Methylenecholesterol 相关抗体

Top Publications Citing Use of Products

查看 Acyltransferase 亚型特异性产品:

查看所有亚型
ACAT1 ACAT2 MGAT2 ACAT

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

24-Methylenecholesterol (Ostreasterol) is a regulator targeting acyl-CoA cholesterol acyltransferase (ACAT) with anti-aging and neuroprotective effects. 24-Methylenecholesterol mimics the effects of nerve growth factor (NGF), can extend yeast lifespan through an anti-oxidative stress mechanism, and exhibits neuroprotective activity in PC12 cells. 24-Methylenecholesterol can reduce intracellular reactive oxygen species (ROS) and malondialdehyde (MDA) levels, activate anti-oxidative stress pathways (such as UTH1, SOD-related genes), and promote synaptic growth[1][2][3].

体内研究
(In Vivo)

24-Methylenecholesterol (0.1-1.0% 干饲料浓度；饮食添加；每日 1 次；3 周) 在意大利蜜蜂模型中，显著上调头部营养标记蛋白 (如 MRJP1、MRJP4-7) 的表达，改善抗氧化酶活性并促进幼虫发育[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Apis mellifera worker bees (female, newly emerged, 80-100 mg body weight), nutritional physiology model[2]
Dosage: 0.1% (S1), 0.25% (S2), 0.5% (S3), 0.75% (S4), 1.0% (S5) 24-Methylenecholesterol dissolved in acetone and mixed into synthetic diets (final acetone concentration <0.5%)
Administration: Oral administration via synthetic diet, replaced daily, treatment for 3 weeks starting from newly emerged adulthood
Result: Treatment with 24-Methylenecholesterol at 0.1-1.0% dry diet concentration significantly altered the head proteome of worker bees.
Compared to the control group, the mean relative abundances of major royal jelly proteins (MRJP1, MRJP4, MRJP5, MRJP7)-key nutritional markers involved in brood food synthesis-were upregulated by 20-35% in the S3-S5 groups (0.5-1.0% sterol).
分子量

398.66

同用名

Ostreasterol

Formula

C28H46O
CAS 号
性状

固体

颜色

White to off-white

结构分类
初始来源

the larva of queen bees and from royal jelly
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
细胞实验： 

Ethanol 中的溶解度 : 16.67 mg/mL (41.82 mM; 超声助溶)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.5084 mL 12.5420 mL 25.0840 mL
5 mM 0.5017 mL 2.5084 mL 5.0168 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

24-Methylenecholesterol 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
Ethanol 1 mM 2.5084 mL 12.5420 mL 25.0840 mL 62.7101 mL
5 mM 0.5017 mL 2.5084 mL 5.0168 mL 12.5420 mL
10 mM 0.2508 mL 1.2542 mL 2.5084 mL 6.2710 mL
15 mM 0.1672 mL 0.8361 mL 1.6723 mL 4.1807 mL
20 mM 0.1254 mL 0.6271 mL 1.2542 mL 3.1355 mL
25 mM 0.1003 mL 0.5017 mL 1.0034 mL 2.5084 mL
30 mM 0.0836 mL 0.4181 mL 0.8361 mL 2.0903 mL
40 mM 0.0627 mL 0.3136 mL 0.6271 mL 1.5678 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

24-Methylenecholesterol474-63-5OstreasterolAcyltransferaseReactive Oxygen Species (ROS)Diacylglycerol acyltransferaseDiglyceride acyltransferaseacyl-CoA:cholesterol acyltransferasemono- acylglycerol acyltransferasenatural marine sterolmacrophagesanti-aginghoney beelongevityInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
24-Methylenecholesterol
目录号：
HY-133968
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z