1. GPCR/G Protein Neuronal Signaling Apoptosis Immunology/Inflammation Protein Tyrosine Kinase/RTK
  2. Adrenergic Receptor TNF Receptor Interleukin Related VEGFR
  3. Naphazoline

Naphazoline  (Synonyms: 萘甲唑啉; Naphthazoline)

目录号: HY-111326
产品使用指南

Naphazoline (Naphthazoline) 是一种有效的 α- 肾上腺素能受体 (α-adrenergic receptor) 激动剂。Naphazoline 能降低血管通透性和促进血管收缩。Naphazoline 可降低炎症因子 (TNF-α、IL-1β 和 IL-6)、细胞因子 (IFN-γ 和 IL-4)、IgE、GMCSF 和 NGF 的水平。Naphazoline 可用于非细菌性结膜炎的研究。

在相同的摩尔浓度下,化合物盐形式与游离形式有相同的生物活性,但盐形式 Naphazoline nitrateNaphazoline hydrochloride 通常具有更好的水溶性和稳定性。

MCE 的所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

Naphazoline Chemical Structure

Naphazoline Chemical Structure

CAS No. : 835-31-4

1.  客户无需承担相应的运输费用。

2.  同一机构(单位)同一产品试用装仅限申领一次,同一机构(单位)一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

Naphazoline 的其他形式现货产品:

Customer Review

Other Forms of Naphazoline:

注册 MCE会员完成审核
即刻享有 积分商城 300 专属积分

Top Publications Citing Use of Products

查看 Adrenergic Receptor 亚型特异性产品:

查看 VEGFR 亚型特异性产品:

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Naphazoline (Naphthazoline) is a potent α-adrenergic receptor agonist. Naphazoline reduces vascular hyperpermeability and promotes vasoconstriction. Naphazoline reduces the levels of inflammatory factors (TNF-α, IL-1β and IL-6), cytokines (IFN-γ and IL-4), IgE, GMCSF, and NGF。Naphazoline can be used for non-bacterial conjunctivitis research[1][2].

IC50 & Target

IL-1β

 

IL-6

 

IL-4

 

体内研究
(In Vivo)

Naphazoline (0.2 mg/kg, 10 µl per eye; IP, once) reduces histamine or antigen-induced conjunctival vascular hyperpermeability in mice, and reduces conjunctivitis in mice via effects on inflammation, NGF and VEGF[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female wild-type BALB/c mice (4-5 weeks, 18 ± 2 g, n=8/group, allergic conjunctivitis mouse model established using histamine or an antigen (ovalbumin))[1]
Dosage: 0.2 mg/mL, 10 µl per eye
Administration: Intraperitoneal injection (IP), once
Result: Significantly suppressed conjunctival dye leakage in mice with histamine or antigen‑induced conjunctival vascular hyperpermeability. Reduced inflammatory reactions and the levels of IL-1β, IL-6, IFN-γ, and IL-4. Reduced the levels of IgE, GMCSF, NGF and VEGF in antigen-induced conjunctival vascular hyperpermeability mice.
Clinical Trial
分子量

210.27

Formula

C14H14N2

CAS 号
中文名称

萘甲唑啉

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称:

 

* 需求量:

* 客户姓名:

 

* Email:

* 电话:

 

* 公司或机构名称:

   留言给我们:

Bulk Inquiry

Inquiry Information

产品名称:
Naphazoline
目录号:
HY-111326
需求量: