2. Gene
  3. FOXA2 - forkhead box A2 Gene

FOXA2 - forkhead box A2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：叉头盒 A2

种属: Homo sapiens

同用名: HNF3B; TCF3B; HNF-3-beta

基因 ID: 3170 | 基因类型: protein coding

关于 FOXA2

Cytogenetic location: 20p11.21 Genomic coordinates (GRCh38): 20:22,580,998-22,585,490 (from NCBI)

This gene has 2 transcripts (splice variants), 198 orthologues, 42 paralogues and is associated with 1 phenotype. Biased expression in stomach (RPKM 15.2), lung (RPKM 9.0) and 8 other tissues.

功能概要

该基因编码叉头类 DNA 结合蛋白的一个成员。这些肝细胞核因子是肝脏特异性基因 (如白蛋白和转甲状腺素蛋白) 的转录激活因子，它们还与染色质相互作用。小鼠中的相似家族成员在代谢调节以及胰腺和肝脏的分化中发挥作用。该基因与年轻人成年后发病的散发性糖尿病病例有关。已经为该基因鉴定了编码不同亚型的转录变体。[RefSeq 提供，2008 年 10 月]

This gene encodes a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific genes such as albumin and transthyretin, and they also interact with chromatin. Similar family members in mice have roles in the regulation of metabolism and in the differentiation of the pancreas and liver. This gene has been linked to sporadic cases of maturity-onset diabetes of the young. Transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Oct 2008]

FOXA2 基因产物(2)

mRNA Protein Name
NM_021784.5 NP_068556.2 hepatocyte nuclear factor 3-beta isoform 1
NM_153675.3 NP_710141.1 hepatocyte nuclear factor 3-beta isoform 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables DNA binding IDA
IDA: 通过直接分析推断
9931457 GOA
enables DNA-binding transcription factor activity IDA
IDA: 通过直接分析推断
9931457 GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: 通过直接分析推断
12642491 GOA
enables nucleic acid binding EXP
EXP: 通过实验结果推断
28644006 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
32814053 GOA
enables sequence-specific double-stranded DNA binding IDA
IDA: 通过直接分析推断
28473536 GOA
enables transcription cis-regulatory region binding IMP
IMP: 通过突变表型推断
15737987 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in dopaminergic neuron differentiation IGI
IGI: 通过遗传相互作用推断
19951692 GOA
involved in endocrine pancreas development IDA
IDA: 通过直接分析推断
12124776 GOA
involved in negative regulation of DNA-binding transcription factor activity IMP
IMP: 通过突变表型推断
12642491 GOA
involved in negative regulation of epithelial to mesenchymal transition IMP
IMP: 通过突变表型推断
20160041 GOA
involved in positive regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
9931457 GOA
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
12124776 GOA
involved in regulation of blood coagulation IDA
IDA: 通过直接分析推断
12911579 GOA
involved in regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
12911579 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in nucleus IDA
IDA: 通过直接分析推断
9931457 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

FOXA2 蛋白结构

Forkhead_N

Forkhead_N: Forkhead N-terminal region (17 - 158)

Forkhead

Forkhead: Forkhead domain (159 - 254)

HNF_C

HNF_C: HNF3 C-terminal domain (373 - 446)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 457 a.a.
蛋白主名 其他名称

hepatocyte nuclear factor 3-beta

forkhead box protein A2

FOXA2 抗体

目录号 产品名 应用 反应物种
HY-P80974 FoxA2 Antibody (YA849) WB, IHC-P Human
HY-P84884 FoxA2 Antibody (YA4581) WB, IHC-P, ELISA Human
HY-P85171 FoxA2 Antibody (YA4863) WB, IHC-P, ICC/IF, ELISA Human

关联疾病

疾病名称 别名
Combined Pituitary Hormone Deficiencies, Genetic Forms

Congenital Hypopituitarism

Pituitary Hormone Deficiency, Combined 1

Congenital Combined Pituitary Hormone Deficiency

Non-Acquired Combined Pituitary Hormone Deficiency

Cphd1

Familial Congenital Hypopituitarism

Multiple Pituitary Hormone Deficiencies, Genetic Forms

Combined Pituitary Hormone Deficiencies, Genetic Form

Hormone Deficiency, Pituitary, Combined, Type 1
Maturity-Onset Diabetes Of The Young

MODY

Maturity Onset Diabetes Mellitus In Young

Mason-Type Diabetes

Mason Type Diabetes

Maturity Onset Diabetes Of The Young

Mody Syndrome

Diabetes Of The Young, Maturity-Onset
Hypopituitarism

Pituitary Hypofunction

Pituitary Insufficiency

Pituitary Hormone Deficiency

Subpituitarism

Hypophyseal Dystrophy

Hypohypophysism

Anterior Pituitary Insufficiency

Deficient Secretion Of One Or More Pituitary Hormones

Hypopituitarism Syndrome

Pituitary Deficiency

Pituitary Failure

Pituitary Insufficiency Nos

Anterior Pituitary Hypofunction

Deficient Secretion Of All Pituitary Hormones

Hypopituitary Dwarfism

Hyposomatotropic Dwarfism

Hypophyseal Dwarfism

Hypopituitary Cachexia

Hypophyseal Short Stature

Panhypopituitarism Syndrome

Pituitary Cachexia

Juvenile Hypopituitarism

Pituitary Dwarfism

Pituitary Gland Hypofunction

Primary Hypopituitarism

Secondary Hypogonadism

Prepubertal Panhypopituitarism

Prepubertal Dwarfism

Postpartum Panhypopituitary Syndrome

Postpartum Hypopituitarism

Pituitary Short Stature

Pituitary Infantilism

Pituitary Hypogonadism

Pituitary Hypoadrenocorticism
Hyperinsulinism

Hyperinsulinemia
Uterine Corpus Endometrial Carcinoma
Pancreatic Agenesis

Partial Pancreatic Agenesis

Congenital Pancreatic Agenesis

Partial Agenesis Of The Pancreas

Agenesis, Pancreatic

Pancreatic Agenesis, Congenital
Germ Cell And Embryonal Cancer

Germ Cell And Embryonal Neoplasm
Arthrogryposis, Distal, Type 1a

Distal Arthrogryposis Type 1

Digitotalar Dysmorphism

DA1A

Da1

Amcd1

Arthrogryposis, Distal, Type 2b4

Distal Arthrogryposis Type 1a

Arthrogryposis, Distal, Type 1

Arthrogryposis Multiplex Congenita Distal Type 1

Arthrogryposis Multiplex Congenita, Distal Type 1

Arthrogryposis Multiplex Congenita, Distal, Type I

Distal Arthrogryposis Type 1b

Arthrogryposis, Distal, 1a

Amc

Arthrogryposis Multiplex Congenita

Arthrogryposis, Distal, 2b4

DA2B4

Arthrogryposis Multiplex Congenita, Distal, Type 1

Arthrogryposis
Hyperinsulinemic Hypoglycemia

Nesidioblastosis

Islet Cell Hyperplasia

Persistent Hyperinsulinemia Hypoglycemia Of Infancy

Hyperinsulinemic Hypoglycaemia
Germ Cell Cancer

Malignant Germ Cell Tumor

Neoplasms, Germ Cell And Embryonal

Germ Cell Neoplasm

Germ Cell Tumour

Malignant Tumor Of The Germ Cell

Neoplasms Germ Cell

Malignant Germ Cell Neoplasm
Permanent Neonatal Diabetes Mellitus

Pndm

Permanent Diabetes Mellitus Of Infancy

Pdmi

Neonatal Diabetes Mellitus, Permanent
Maturity-Onset Diabetes Of The Young, Type 3

Maturity-Onset Diabetes Of The Young Type 3

MODY3

Mody, Type Iii

Mody Type 3

Mody, Type 3

Maturity-Onset Diabetes Of The Young 3

Mody-3

Diabetes Of The Young, Maturity-Onset, Type 3
Type 2 Diabetes Mellitus

Insulin Resistance

NIDDM

Type 2 Diabetes

Diabetes Mellitus, Non-Insulin-Dependent

T2D

Noninsulin-Dependent Diabetes Mellitus

Diabetes Mellitus, Type Ii

Maturity-Onset Diabetes

Insulin Resistance, Severe, Digenic

Diabetes Mellitus, Type 2

Diabetes Mellitus, Noninsulin-Dependent

Diabetes Mellitus, Noninsulin-Dependent, Association With

Diabetes Mellitus, Noninsulin-Dependent, Late Onset

Hypertension, Insulin Resistance-Related, Susceptibility To

Insulin Resistance, Susceptibility To

Non-Insulin-Dependent Diabetes Mellitus

Type Ii Diabetes Mellitus

Adult-Onset Diabetes Mellitus

Maturity-Onset Diabetes Mellitus

Diabetes Mellitus Type 2

Type Ii Diabetes

Type 2 Diabetes Mellitus, Susceptibility To

Diabetes, Type 2

Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To

Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To

Diabetes Mellitus, Type 2, Susceptibility To

Diabetes Mellitus, Noninsulin-Dependent, 2

Diabetes Mellitus, Type Ii, Susceptibility To

Hypertension, Insulin Resistance-Related

Adult-Onset Diabetes

Aodm

Diabetes Mellitus, Adult-Onset

Diabetes Mellitus Type Ii

Diabetes Mellitus Type 2, Susceptibility To

Diabetes, Type Ii, Susceptibility To

Diabetes Type 2

Diabetes Mellitus

Adult Onset Diabetes

Maturity Onset Diabetes

Nonketotic Diabetes

Non-Insulin Dependent Diabetes Mellitus

T2dm - [Type 2 Diabetes Mellitus]

Niddm - [Non Insulin Dependent Diabetes Mellitus]

Dm2

Dm Type Ii

Diabetic Type 2

Insulin Requiring Type 2 Diabetes

Noninsulin Dependent Diabetes

Non-Insulin-Dependent Diabetes Mellitus Without Complications

Diabetes Due To Insulin Secretory Defect

Diabetes Mellitus Due To Insulin Secretory Defect

Non-Insulin-Dependent Diabetes Of The Young

Senile Diabetes

Nonketotic Hyperglycaemia

Stable Diabetes
Diabetes Mellitus

Diabetes
Body Mass Index Quantitative Trait Locus 11

OBESITY

Obesity, Susceptibility To

Leanness, Inherited

Obesity, Susceptibility To, Bmiq11

Obesity, Mild, Early-Onset

Obesity, Association With

Obesity, Early-Onset, Susceptibility To

Obesity, Severe

Obesity, Severe, And Type Ii Diabetes

Obesity, Late-Onset

Obesity , Susceptibility To

BMIQ11

Obesity Bmiq11

Obesity, Early-Onset

Simple Obesity Nos

Excess Fat

Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified

Adiposis
Congenital Nervous System Abnormality

Congenital Neurologic Anomaly

Congenital Nervous System Disorder
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS05037 FOXA2 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS18820 Foxa2 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS25310 Foxa2 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta FOXA2 VGNC VGNC:72708
Felis catus FOXA2 VGNC VGNC:67601
Canis familiaris FOXA2 VGNC VGNC:40944
Rattus norvegicus FOXA2 RGD RGD:2808
Mus musculus FOXA2 MGD MGI:1347476
Bos taurus FOXA2 VGNC VGNC:29078
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