2. Gene
  3. Lig4 - ligase IV, DNA, ATP-dependent Gene

Lig4 - ligase IV, DNA, ATP-dependent Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: tiny; 5830471N16Rik

基因 ID: 319583 | 基因类型: protein coding

关于 Lig4

功能概要

Enables ATP binding activity and DNA Ligase (ATP) activity. Involved in double-strand break repair via nonhomologous end joining. Acts upstream of or within several processes, including DNA metabolic process; hemopoiesis; and nervous system development. Part of DNA-dependent protein kinase-DNA Ligase 4 complex. Is expressed in metanephros. Used to study DNA Ligase IV deficiency. Human ortholog(s) of this gene implicated in several diseases, including DNA Ligase IV deficiency; colorectal cancer; high grade glioma; multiple myeloma; and prostate Cancer. Orthologous to human LIG4 (DNA Ligase 4). [provided by Alliance of Genome Resources, Apr 2022]

Lig4 基因产物(2)

mRNA Protein Name
NM_001377042.1 NP_001363971.1 DNA ligase 4
NM_176953.4 NP_795927.2 DNA ligase 4
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables ATP binding IDA
IDA: 通过直接分析推断
15194694 MGI
enables DNA ligase (ATP) activity IDA
IDA: 通过直接分析推断
15194694 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
20620605 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within DN2 thymocyte differentiation IMP
IMP: 通过突变表型推断
9823897 MGI
acts upstream of or within DNA ligation IDA
IDA: 通过直接分析推断
15194694 MGI
acts upstream of or within DNA ligation IMP
IMP: 通过突变表型推断
15968270 MGI
acts upstream of or within DNA ligation involved in DNA recombination IMP
IMP: 通过突变表型推断
9823897 MGI
acts upstream of or within DNA ligation involved in DNA repair IMP
IMP: 通过突变表型推断
9823897 MGI
acts upstream of or within DNA repair IMP
IMP: 通过突变表型推断
11779495 MGI
acts upstream of or within T cell receptor V(D)J recombination IMP
IMP: 通过突变表型推断
10911993 MGI
acts upstream of or within V(D)J recombination IDA
IDA: 通过直接分析推断
15194694 MGI
acts upstream of or within V(D)J recombination IMP
IMP: 通过突变表型推断
10716994 MGI
acts upstream of or within central nervous system development IGI
IGI: 通过遗传相互作用推断
10911993 MGI
acts upstream of or within central nervous system development IMP
IMP: 通过突变表型推断
9875844 MGI
acts upstream of or within chromosome organization IGI
IGI: 通过遗传相互作用推断
15175260 MGI
acts upstream of or within double-strand break repair IGI
IGI: 通过遗传相互作用推断
12531011 MGI
acts upstream of or within double-strand break repair IMP
IMP: 通过突变表型推断
12531011 MGI
acts upstream of or within double-strand break repair via nonhomologous end joining IMP
IMP: 通过突变表型推断
10823907 MGI
involved in double-strand break repair via nonhomologous end joining IMP
IMP: 通过突变表型推断
12361565 MGI
acts upstream of fibroblast proliferation IMP
IMP: 通过突变表型推断
9823897 MGI
acts upstream of or within fibroblast proliferation IMP
IMP: 通过突变表型推断
15175260 MGI
acts upstream of or within immunoglobulin V(D)J recombination IMP
IMP: 通过突变表型推断
9823897 MGI
acts upstream of or within in utero embryonic development IMP
IMP: 通过突变表型推断
9823897 MGI
acts upstream of or within isotype switching IMP
IMP: 通过突变表型推断
17713479 MGI
acts upstream of or within negative regulation of neuron apoptotic process IGI
IGI: 通过遗传相互作用推断
10911993 MGI
acts upstream of or within negative regulation of neuron apoptotic process IMP
IMP: 通过突变表型推断
9875844 MGI
acts upstream of neurogenesis IMP
IMP: 通过突变表型推断
9875844 MGI
acts upstream of neuron apoptotic process IGI
IGI: 通过遗传相互作用推断
10911993 MGI
acts upstream of or within neuron apoptotic process IGI
IGI: 通过遗传相互作用推断
11248063 MGI
acts upstream of neuron apoptotic process IMP
IMP: 通过突变表型推断
9875844 MGI
acts upstream of or within positive regulation of fibroblast proliferation IMP
IMP: 通过突变表型推断
9823897 MGI
acts upstream of or within positive regulation of neurogenesis IMP
IMP: 通过突变表型推断
9875844 MGI
acts upstream of or within pro-B cell differentiation IMP
IMP: 通过突变表型推断
9823897 MGI
acts upstream of or within response to gamma radiation IMP
IMP: 通过突变表型推断
9823897 MGI
acts upstream of or within response to ionizing radiation IMP
IMP: 通过突变表型推断
10823907 MGI
acts upstream of or within somatic stem cell population maintenance IMP
IMP: 通过突变表型推断
17554302 MGI
acts upstream of or within stem cell proliferation IMP
IMP: 通过突变表型推断
17554302 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of DNA-dependent protein kinase-DNA ligase 4 complex IDA
IDA: 通过直接分析推断
15194694 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

DNA ligase 4

DNA ligase IV

polydeoxyribonucleotide synthase [ATP] 4

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS07644 LIG4 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS19909 Lig4 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS26410 Lig4 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Lig4 NCBI NCBI:3981
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