2. Gene
  3. JMJD8 - jumonji domain containing 8 Gene

JMJD8 - jumonji domain containing 8 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：含 Jumonji 域 8

种属: Homo sapiens

同用名: PP14397; C16orf20

基因 ID: 339123 | 基因类型: protein coding

关于 JMJD8

This gene has 15 transcripts (splice variants), 190 orthologues and 2 paralogues. Ubiquitous expression in thyroid (RPKM 36.7), kidney (RPKM 34.2) and 25 other tissues.

功能概要

参与多个过程，包括 I-kappaB 激酶/NF-kappaB 信号的正调控；发芽血管生成的正调节；和糖酵解过程的调节。位于内质网腔和细胞核内。 [由基因组资源联盟提供，2022 年 4 月]

Involved in several processes, including positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of sprouting angiogenesis; and regulation of glycolytic process. Located in endoplasmic reticulum lumen and nucleus. [provided by Alliance of Genome Resources, Apr 2022]

JMJD8 基因产物(5)

mRNA Protein Name
NM_001005920.4 NP_001005920.3 jmjC domain-containing protein 8 isoform 1 precursor
NM_001323918.3 NP_001310847.2 jmjC domain-containing protein 8 isoform 2 precursor
NM_001323919.3 NP_001310848.2 jmjC domain-containing protein 8 isoform 3 precursor
NM_001323920.3 NP_001310849.2 jmjC domain-containing protein 8 isoform 4 precursor
NM_001323922.3 NP_001310851.2 jmjC domain-containing protein 8 isoform 5 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
27199445 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in positive regulation of canonical NF-kappaB signal transduction IMP
IMP: 通过突变表型推断
27671354 GOA
involved in positive regulation of sprouting angiogenesis IMP
IMP: 通过突变表型推断
27199445 GOA
involved in regulation of glycolytic process IMP
IMP: 通过突变表型推断
27199445 GOA
involved in regulation of pyruvate kinase activity IMP
IMP: 通过突变表型推断
27199445 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
27199445 GOA
located in endoplasmic reticulum IDA
IDA: 通过直接分析推断
29133832 GOA
located in endoplasmic reticulum lumen IDA
IDA: 通过直接分析推断
29133832 GOA
located in nucleus IDA
IDA: 通过直接分析推断
29133832 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

JMJD8 蛋白结构

Cupin_8

Cupin_8: Cupin-like domain (81 - 270)

  • 0
  • 100
  • 200
  • 285 a.a.
蛋白主名 其他名称

jmjC domain-containing protein 8

jumonji domain-containing protein 8

关联疾病

疾病名称 别名
Spinocerebellar Ataxia 48

SCA48
Spinocerebellar Ataxia, Autosomal Recessive 16

Autosomal Recessive Spinocerebellar Ataxia 16

SCAR16

Autosomal Recessive Cerebellar Ataxia Due To Stub1 Deficiency

Spinocerebellar Ataxia Autosomal Recessive Type 16

Spinocerebellar Ataxia, Autosomal Recessive, 16

Ataxia, Spinocerebellar, Autosomal Recessive, Type 16
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS07041 JMJD8 Human Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus JMJD8 VGNC VGNC:63008
Bos taurus JMJD8 VGNC VGNC:58602
Macaca mulatta JMJD8 VGNC VGNC:73826
Rattus norvegicus JMJD8 RGD RGD:1307381
Mus musculus JMJD8 MGD MGI:1919356
Canis familiaris JMJD8 VGNC VGNC:42190
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