Brd7 - bromodomain containing 7 Gene

中文名称：含溴结构域 7

种属: Rattus norvegicus

关于 Brd7

功能概要

预计该基因编码的蛋白具有多种功能，包括赖氨酸乙酰化组蛋白结合活性； p53 结合活性；和转录共激活因子活性。预计参与多个过程，包括有丝分裂细胞周期G1/S转换的负调控；组蛋白乙酰化的正调控；和转录调控，DNA 模板化。预计位于胞质溶胶和核质中。预计活跃于核心。该基因的人类直系同源物与急性髓性白血病有关。与人类 BRD7（含 7 的溴结构域）同源。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable several functions, including lysine-acetylated histone binding activity; p53 binding activity; and transcription coactivator activity. Predicted to be involved in several processes, including negative regulation of G1/S transition of mitotic cell cycle; positive regulation of histone acetylation; and regulation of transcription, DNA-templated. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in acute myeloid leukemia. Orthologous to human BRD7 (bromodomain containing 7). [provided by Alliance of Genome Resources, Apr 2022]