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  3. (2S,3R)-LP99

(2S,3R)-LP99 是一种有效的选择性 BRD7BRD9 抑制剂,BRD9 的 KD 值为 99 nM。(2S,3R)-LP99 在体外和细胞中抑制 BRD7 和 BRD9 与乙酰化组蛋白的结合。(2S,3R)-LP99证明 BRD7/9 在调节促炎细胞因子分泌中发挥作用。

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(2S,3R)-LP99 Chemical Structure

(2S,3R)-LP99 Chemical Structure

CAS No. : 1808948-28-8

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规格 价格 是否有货 数量
5 mg ¥5098
3 - 4 周
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Top Publications Citing Use of Products
  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

(2S,3R)-LP99 is a potent and selective BRD7 and BRD9 inhibitor with an KD of 99 nM for BRD9. (2S,3R)-LP99 inhibits the association of BRD7 and BRD9 to acetylated histones in vitro and in cells. (2S,3R)-LP99 demonstrates that BRD7/9 plays a role in regulating pro-inflammatory cytokine secretion[1].

IC50 & Target[1]

BRD7

 

BRD9

99 nM (Kd)

体外研究
(In Vitro)

(2S,3R)-LP99 (compound 60) (0-100 µM) inhibits the expression of IL6 in LPS-stimulated (100 ng/mL) THP-1 cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

516.05

Formula

C26H30ClN3O4S

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献

(2S,3R)-LP99 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
(2S,3R)-LP99
目录号:
HY-116227
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