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  2. KCND1 - potassium voltage-gated channel subfamily D member 1 Gene

KCND1 - potassium voltage-gated channel subfamily D member 1 Gene

中文名称:钾电压门控通道亚家族 D 成员 1

种属: Homo sapiens

同用名: KV4.1

基因 ID: 3750 | 基因类型: protein coding

关于 KCND1

Cytogenetic location: Xp11.23 Genomic coordinates (GRCh38): X:48,961,380-48,971,844 (from NCBI)

This gene has 3 transcripts (splice variants), 85 orthologues and 31 paralogues. Ubiquitous expression in gall bladder (RPKM 1.4), brain (RPKM 1.1) and 24 other tissues.

功能概要

该基因编码一种多通道膜蛋白,该蛋白包含电压门控 A 型钾通道的孔亚基,其在膜动作电位的复极化中起作用。电压门控钾通道的活性在许多生理过程中都很重要,其中包括调节神经递质释放、心率、胰岛素分泌和平滑肌收缩。[RefSeq 提供,2013 年 8 月]

This gene encodes a multipass membrane protein that comprises the pore subunit of the voltage-gated A-type Potassium Channel, which functions in the repolarization of membrane action potentials. Activity of voltage-gated potassium channels is important in a number of physiological processes, among them the regulation of neurotransmitter release, heart rate, Insulin secretion, and smooth muscle contraction. [provided by RefSeq, Aug 2013]

KCND1 基因产物(1)

mRNA Protein Name
NM_004979.6 NP_004970.3 potassium voltage-gated channel subfamily D member 1 precursor
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables A-type (transient outward) potassium channel activity IDA
IDA: 通过直接分析推断
15454437 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

KCND1 蛋白结构

Shal-type

Shal-type: Shal-type voltage-gated potassium channels, N-terminal (3 - 31)

BTB_2

BTB_2: BTB/POZ domain (43 - 131)

Ion_trans

Ion_trans: Ion transport protein (233 - 407)

DUF3399

DUF3399: Domain of unknown function (DUF3399) (447 - 550)

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  • 647 a.a.
蛋白主名 其他名称

potassium voltage-gated channel subfamily D member 1

Shal-type potassium channel

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus KCND1 RGD RGD:621364
Macaca mulatta KCND1 VGNC VGNC:73975
Felis catus KCND1 VGNC VGNC:67901
Mus musculus KCND1 MGD MGI:96671
Bos taurus KCND1 VGNC VGNC:30434
Canis familiaris KCND1 VGNC VGNC:42239