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  3. KIF22 - kinesin family member 22 Gene

KIF22 - kinesin family member 22 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：驱动蛋白家族成员 22

种属: Homo sapiens

同用名: KID; OBP; KNSL4; OBP-1; OBP-2; SEMDJL2; A-328A3.2

基因 ID: 3835 | 基因类型: protein coding

关于 KIF22

Cytogenetic location: 16p11.2 Genomic coordinates (GRCh38): 16:29,790,751-29,805,385 (from NCBI)

This gene has 33 transcripts (splice variants), 179 orthologues, 41 paralogues and is associated with 3 phenotypes. Broad expression in bone marrow (RPKM 24.9), testis (RPKM 13.3) and 24 other tissues.

功能概要

该基因编码的蛋白质是驱动蛋白样蛋白家族的一员。该家族成员是依赖微管的分子马达，可在细胞内运输细胞器并在细胞分裂期间移动染色体。该蛋白质的 C 端一半已显示可结合 DNA。对非洲爪蟾同系物的研究表明其在中期染色体排列和维护中的重要作用。已发现该基因编码不同亚型的可变剪接转录物变体。[RefSeq 提供，2012 年 1 月]

The protein encoded by this gene is a member of the kinesin-like protein family. The family members are microtubule-dependent molecular motors that transport organelles within cells and move chromosomes during cell division. The C-terminal half of this protein has been shown to bind DNA. Studies with the Xenopus homolog suggests its essential role in metaphase chromosome alignment and maintenance. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]

KIF22 基因产物(3)

mRNA Protein Name
NM_001256269.2 NP_001243198.1 kinesin-like protein KIF22 isoform 2
NM_001256270.1 NP_001243199.1 kinesin-like protein KIF22 isoform 2
NM_007317.3 NP_015556.1 kinesin-like protein KIF22 isoform 1

KIF22 蛋白结构

Kinesin

Kinesin: Kinesin motor domain (69 - 368)

HHH_3

HHH_3: Helix-hairpin-helix motif (596 - 646)

  • 0
  • 200
  • 400
  • 600
  • 665 a.a.
蛋白主名 其他名称

kinesin-like protein KIF22

kinesin-like DNA-binding protein pseudogene

KIF22 抗体

目录号 产品名 应用 反应物种
HY-P82753 Phospho-KIF22 (Ser427) Antibody (YA2498) WB Human
HY-P84576 KID Antibody (YA4273) IHC-P, FC, ELISA Human
HY-P85238 KID Antibody (YA4930) WB, IHC-P, ICC/IF, FC, ELISA Human

关联疾病

疾病名称 别名
Spondyloepimetaphyseal Dysplasia With Joint Laxity, Type 2

SEMDJL2

Spondyloepimetaphyseal Dysplasia With Joint Laxity, Leptodactylic Type

Spondyloepimetaphyseal Dysplasia With Multiple Dislocations, Hall Type

Spondyloepimetaphyseal Dysplasia With Joint Laxity Type 2

Spondyloepimetaphyseal Dysplasia With Multiple Dislocations Hall Type

Spondyloepimetaphyseal Dysplasia With Joint Laxity, Hall Type

Semd-Md

Spondyloepimetaphyseal Dysplasia With Joint Laxicity, Hall Type

Spondyloepimetaphyseal Dysplasia With Joint Laxity, 2

Lepto-Semdjl

Spondyloepimetaphyseal Dysplasia With Joint Laxity Hall Type

Spondyloepimetaphyseal Dysplasia With Joint Laxity Leptodactylic Type

Spondyloepimetaphyseal Dysplasia With Multiple Dislocations
Spondyloepimetaphyseal Dysplasia With Multiple Dislocations

Spondyloepimetaphyseal Dysplasia With Multiple Dislocations Hall Type

Spondyloepimetaphyseal Dysplasia With Multiple Dislocations Leptodactylic Type

Semd-Md

Semdjl2

Spondyloepimetaphyseal Dysplasia With Joint Laxicity, Hall Type

Spondyloepimetaphyseal Dysplasia With Joint Laxity Type 2

Spondyloepimetaphyseal Dysplasia With Joint Laxity, Leptodactylic Type

Spondyloepimetaphyseal Dysplasia With Multiple Dislocations, Hall Type
Spondyloepimetaphyseal Dysplasia With Joint Laxity

Dysplasia, Spondyloepimetaphyseal, With Joint Laxity

Semdjl

Spondyloepimetaphyseal Dysplasia Joint Laxity

Semd-Jl

Semdjl1

Spondyloepimetaphyseal Dysplasia With Joint Laxity Type 1

Spondyloepimetaphyseal Dysplasia With Joint Laxity, Beighton Type
Spondyloepimetaphyseal Dysplasia

Dysplasia, Spondyloepimetaphyseal
Spondylocostal Dysostosis 5

Spondylothoracic Dysostosis

SCDO5

Jarcho-Levin Syndrome

Scoliosis, Congenital, With Or Without Rib Anomalies

Tacs

Spondylocostal Dysplasia

Costovertebral Segmentation Anomalies

Spondylocostal Dysostosis 1

Spondylocostal Dysostosis

Spondylothoracic Dysplasia

Scdo1

Spondylocostal Dysostosis 1 Autosomal Recessive

Costovertebral Dysplasia

Scdo

Std

Autosomal Dominant Spondylocostal Dysostosis

Autosomal Dominant Spondylocostal Dysplasia

Doid:0112363

Spondylocostal Dysostosis 4, Autosomal Dominant
Bone Disease

Bone Diseases

Skeletal Disease

Skeletal Disorder

Disorder Of Skeletal System
Spondylocostal Dysostosis

Jarcho-Levin Syndrome

Costovertebral Dysplasia

Spondylothoracic Dysostosis

Spondylothoracic Dysplasia

Scdo

Dysostosis, Spondylocostal
Scoliosis
Benign Familial Infantile Epilepsy

Benign Familial Infantile Seizures

Bfie

Benign Familial Infantile Convulsion

Bfic

Bfis

Benign Familial Infantile Convulsions

Familial Benign Neonatal Epilepsy

Watanabe-Vigevano Syndrome
Osteochondrodysplasia

Skeletal Dysplasia

Chondrodystrophy

Congenital Anomaly Of Cartilage

Osteochondrodysplasias

Cartilage Development Disorder

Osteochondrodysplasia Syndrome

Dysplasia, Skeletal

Mucopolysaccharidosis Iv
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS07276 KIF22 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS21617 Kif22 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS28135 Kif22 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus KIF22 VGNC VGNC:30596
Canis familiaris KIF22 VGNC VGNC:42398
Felis catus KIF22 VGNC VGNC:67973
Rattus norvegicus KIF22 RGD RGD:1311886
Mus musculus KIF22 MGD MGI:109233
Macaca mulatta KIF22 VGNC VGNC:74033
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