ADAM11 - ADAM metallopeptidase domain 11 Gene

中文名称：ADAM 金属肽酶结构域 11

种属: Homo sapiens

同用名: MDC

基因 ID: 4185 | 基因类型: protein coding

关于 ADAM11

Cytogenetic location: 17q21.31 Genomic coordinates (GRCh38): 17:44,758,988-44,781,846 (from NCBI)

This gene has 5 transcripts (splice variants), 246 orthologues and 20 paralogues. Biased expression in brain (RPKM 9.4), heart (RPKM 3.1) and 5 other tissues.

功能概要

该基因编码 ADAM (一种解整合素和金属蛋白酶) 蛋白家族的成员。该家族的成员是膜锚定蛋白，在结构上与蛇毒解离蛋白相关，并且涉及涉及细胞-细胞和细胞-基质相互作用的各种生物过程，包括受精、肌肉发育和神经发生。编码的前原蛋白经过蛋白水解处理以产生成熟的蛋白酶。该基因代表人类乳腺癌的候选肿瘤抑制基因，基于其在先前由肿瘤缺失映射定义的染色体 17q21 的最小区域内的位置。可变剪接导致多个转录本变体，其中至少一个编码一种经过蛋白水解处理的亚型。[RefSeq 提供，2016 年 1 月]

This gene encodes a member of the ADAM (a disintegrin and metalloprotease) protein family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The encoded preproprotein is proteolytically processed to generate the mature protease. This gene represents a candidate tumor suppressor gene for human breast Cancer based on its location within a minimal region of chromosome 17q21 previously defined by tumor deletion mapping. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016]

ADAM11 基因产物(2)

mRNA	Protein	Name
NM_001318933.2	NP_001305862.1	disintegrin and metalloproteinase domain-containing protein 11 isoform 3
NM_002390.6	NP_002381.2	disintegrin and metalloproteinase domain-containing protein 11 isoform 1 preproprotein

ADAM11 蛋白结构

Pep_M12B_propep

Reprolysin

Disintegrin

ADAM_CR

0
200
400
600
769 a.a.

蛋白主名

其他名称

disintegrin and metalloproteinase domain-containing protein 11

ADAM 11

关联疾病

疾病名称

别名

Epilepsy, Familial Temporal Lobe, 1

ETL1	Adpeaf
Adlte	Epilepsy, Partial, With Auditory Features
Autosomal Dominant Partial Epilepsy With Auditory Features	Epilepsy, Lateral Temporal Lobe, Autosomal Dominant
Familial Temporal Lobe Epilepsy 1	Partial Epilepsy With Auditory Features
Autosomal Dominant Lateral Temporal Lobe Epilepsy	Lateral Temporal Lobe Epilepsy Autosomal Dominant
Epilepsy, Temporal Lobe, Familial, Type 1

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS00268	ADAM11 Human Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS19048	Adam11 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS25538	Adam11 Rat Pre-designed siRNA Set A	Pre-designed Set	/	否

直系同源

种属	基因名	来源	基因 ID
Canis familiaris	ADAM11	VGNC	VGNC:37573
Macaca mulatta	ADAM11	VGNC	VGNC:69466
Rattus norvegicus	ADAM11	RGD	RGD:1307515
Bos taurus	ADAM11	VGNC	VGNC:55768
Mus musculus	ADAM11	MGD	MGI:1098667
Felis catus	ADAM11	VGNC	VGNC:59574
Others	ADAM11	NCBI

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

ADAM11 - ADAM metallopeptidase domain 11 Gene

关于 ADAM11

功能概要

ADAM11 基因产物(2)

ADAM11 蛋白结构

关联疾病

直系同源

热门区域

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ADAM11 - ADAM metallopeptidase domain 11 Gene

关于 ADAM11

功能概要

ADAM11 基因产物(2)

ADAM11 蛋白结构

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z