ASGR2 - asialoglycoprotein receptor 2 Gene

中文名称：去唾液酸糖蛋白受体 2

种属: Homo sapiens

同用名: HL-2; HBXBP; ASGPR2; ASGP-R2; CLEC4H2

关于 ASGR2

功能概要

该基因编码脱唾液酸糖蛋白受体的一个亚基。该受体是一种跨膜蛋白，通过介导具有暴露的末端半乳糖或 N-乙酰半乳糖胺残基的糖蛋白的内吞作用和溶酶体降解，在血清糖蛋白稳态中起关键作用。脱唾液酸糖蛋白受体可能促进包括乙型肝炎在内的多种病毒对肝脏的感染，并且也是肝脏特异性药物递送的靶标。脱唾液酸糖蛋白受体是由不同基因编码的主要和次要亚基组成的异源寡聚蛋白。由该基因编码的蛋白质是不太丰富的次要亚基。已经观察到该基因编码多种亚型的可变剪接转录物变体。[RefSeq 提供，2011 年 1 月]

This gene encodes a subunit of the asialoglycoprotein receptor. This receptor is a transmembrane protein that plays a critical role in serum glycoprotein homeostasis by mediating the endocytosis and lysosomal degradation of glycoproteins with exposed terminal galactose or N-acetylgalactosamine residues. The asialoglycoprotein receptor may facilitate hepatic Infection by multiple viruses including hepatitis B, and is also a target for liver-specific drug delivery. The asialoglycoprotein receptor is a hetero-oligomeric protein composed of major and minor subunits, which are encoded by different genes. The protein encoded by this gene is the less abundant minor subunit. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]