ATP1B1 - ATPase Na+/K+ transporting subunit beta 1 Gene

中文名称：ATPase Na+/K+ 转运亚基 beta 1

种属: Homo sapiens

同用名: ATP1B

基因 ID: 481 | 基因类型: protein coding

关于 ATP1B1

Cytogenetic location: 1q24.2 Genomic coordinates (GRCh38): 1:169,106,690-169,132,719 (from NCBI)

This gene has 19 transcripts (splice variants), 293 orthologues, 4 paralogues and is associated with 1 phenotype. Broad expression in kidney (RPKM 716.2), brain (RPKM 270.1) and 14 other tissues.

功能概要

该基因编码的蛋白质属于 Na+/K+ 和 H+/K+ ATPases β 链蛋白家族，以及 Na+/K+ -ATPases 亚家族。 Na+/K+ -ATPase 是一种完整的膜蛋白，负责建立和维持 Na 和 K 离子跨质膜的电化学梯度。这些梯度对于渗透调节、各种有机和无机分子的钠偶联转运以及神经和肌肉的电兴奋性至关重要。这种酶由两个亚基组成，一个大的催化亚基 (α) 和一个较小的糖蛋白亚基 (β) 。 β 亚基通过组装 α/β 异二聚体来调节输送到质膜的钠泵的数量。 Na+/K+ -ATPase 的糖蛋白亚基由多个基因编码。该基因编码一个 beta 1 亚基。已经描述了编码不同亚型的选择性剪接转录物变体，但它们的生物学有效性尚不清楚。[RefSeq 提供，2010 年 3 月]

The protein encoded by this gene belongs to the family of Na+/K+ and H+/K+ ATPases beta chain proteins, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This Enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane. The glycoprotein subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes a beta 1 subunit. Alternatively spliced transcript variants encoding different isoforms have been described, but their biological validity is not known. [provided by RefSeq, Mar 2010]

ATP1B1 基因产物(1)

mRNA	Protein	Name
NM_001677.4	NP_001668.1	sodium/potassium-transporting ATPase subunit beta-1

ATP1B1 蛋白结构

Na_K-ATPase

0
100
200
303 a.a.

蛋白主名

其他名称

sodium/potassium-transporting ATPase subunit beta-1

ATPase, Na+/K+ transporting, beta 1 polypeptide

重组 ATP1B1 蛋白

目录号	产品名	蛋白编号	纯度
HY-P75586	ATP1B1 Protein, Human (HEK293, His)	P05026-1 (E63-S303)	≥95%

关联疾病

疾病名称

别名

Hypertension, Essential

Essential Hypertension	Hypertension
High Blood Pressure	Hypertension, Essential, Susceptibility To
Hypertensive Disease	Primary Hypertension
EHT	Hypertension, Salt-Sensitive Essential, Susceptibility To
Hyperpiesia	Idiopathic Hypertension
Hypertensive Disorder	Hypertension, Essential, Susceptibility To, 3
Hypertension, Essential 3	Hypertension, Essential, Salt-Sensitive
Hypertension, Essential, Susceptibility To, 6	Hypertension, Essential 6
Hypertension, Salt-Sensitive Essential	Hypertension, Susceptibility To
Hypertension, Essential, Susceptibility To, 4	Hypertension, Essential 4
Hypertension, Essential, Susceptibility To, 2	Hypertension, Essential 2
Hypertension, Essential, Susceptibility To, 1	Hypertension, Essential 1
Hypertension, Essential, Susceptibility To, 5	Hypertension, Essential 5
Htn	Vascular Hypertensive Disorder
Systemic Primary Arterial Hypertension	Hbp - [High Blood Pressure]
Systemic Arterial Hypertensive Disorder	Elevated Blood Pressure
Arterial Hypertension Nos	Hypertension Nos
Benign Hypertension	Systemic Arterial Hypertension
Systemic Hypertension	Artery Htn
Benign Htn	Vascular Htn
Vascular Hypertension	Cholesterol Hypertension
Cholesterol Htn	Idiopathic Htn
Malignant Hypertension	Malignant Htn
Raised Blood Pressure	Cardiovascular Hypertension
Primary Htn - [Hypertension]	High Arterial Tension
High Blood Pressure Disorder	Ht - [Hypertension]
Htn - [Hypertension]	Hypertensive Vascular Disease
Hypertensive Vascular Degeneration

Familial Hemiplegic Migraine

Hemiplegic Migraine, Familial	Hemiplegic-Ophthalmoplegic Migraine
Fhm	Hemiplegic Migraine Familial

Petroclival Meningioma

Fibrolamellar Carcinoma

Fibrolamellar Hepatocellular Carcinoma	Fhcc
Fibrolamellar Hepatocarcinoma	Hepatocellular Carcinoma, Fibrolamellar
Oncocytic Hepatocellular Tumor	Eosinophilic Glassy Cell Hepatoma
Eosinophilic Hepatocellular Carcinoma With Lamellar Fibrosis	Fl-Hcc
Fibrolamellar Oncocytic Hepatoma	Hepatocellular Carcinoma With Increased Stromal Fibrosis
Polygonal Cell Hepatocellular Carcinoma With Fibrous Stroma

Alternating Hemiplegia Of Childhood

Alternating Hemiplegia	Ahc
Alternating Hemiplegia Syndrome	Hemiplegia, Alternating, Of Childhood
Hemiplegia, Crossed

Fuchs' Endothelial Dystrophy

Fuchs Endothelial Corneal Dystrophy	Fuchs Endothelial Dystrophy
Fuchs Dystrophy	Fced
Fuchs' Corneal Dystrophy	Fuchs' Endothelial Corneal Dystrophy
Fuchs Atrophy	Fuchs Corneal Dystrophy
Endoepithelial Corneal Dystrophy	Fecd
Late Hereditary Endothelial Dystrophy	Corneal Dystrophy, Fuchs Endothelial
Dystrophy, Corneal, Fuchs Endothelial	Corneal Dystrophy, Fuchs' Endothelial, 1

Amyotrophic Lateral Sclerosis 1

Amyotrophic Lateral Sclerosis	ALS
Lou Gehrig Disease	Amyotrophic Lateral Sclerosis Type 1
Charcot Disease	ALS1
Amyotrophic Lateral Sclerosis, Susceptibility To	Fals
Lou Gehrig'S Disease	Mnd
Motor Neuron Disease	Familial Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis 1, Familial	Amyotrophic Lateral Sclerosis 1, Autosomal Dominant
Motor Neuron Disease, Bulbar	Motor Neurone Disease
Amyotrophic Lateral Sclerosis With Dementia	Dementia With Amyotrophic Lateral Sclerosis
Motor Neuron Disease, Amyotrophic Lateral Sclerosis	Sclerosis, Lateral, Amyotrophic
Sclerosis, Lateral, Amyotrophic, Type 1	Amyotrophic Sclerosis
Als - [Amyotrophic Lateral Sclerosis]	Wasting Palsy
Amyotrophic Paralysis	Amyotrophy Lateral Sclerosis
Wasting Paralysis	Spinal Progressive Amyotrophy
Progressive Atrophic Paralysis

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-P1565A	Transdermal Peptide Disulfide TFA	Inhibitor	99.38%	否
HY-P1565	Transdermal Peptide Disulfide	Inhibitor	/	否
HY-RS01186	ATP1B1 Human Pre-designed siRNA Set A		/	否

直系同源

种属	基因名	来源	基因 ID
Macaca mulatta	ATP1B1	VGNC	VGNC:70176
Rattus norvegicus	ATP1B1	RGD	RGD:2170
Canis familiaris	ATP1B1	VGNC	VGNC:38248
Felis catus	ATP1B1	VGNC	VGNC:68583
Bos taurus	ATP1B1	VGNC	VGNC:26285
Mus musculus	ATP1B1	MGD	MGI:88108
Others	ATP1B1	NCBI

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。沪(浦)应急管危经许[2021]201709(QFYS)	站点地图隐私声明
Copyright © 2013-2024 MedChemExpress. All Rights Reserved.	沪ICP备15051369号-4

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。沪(浦)应急管危经许[2021]201709(QFYS)

站点地图隐私声明

ATP1B1 - ATPase Na+/K+ transporting subunit beta 1 Gene

关于 ATP1B1

功能概要

ATP1B1 基因产物(1)

ATP1B1 蛋白结构

重组 ATP1B1 蛋白

关联疾病

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

姓名
邮箱 *

Sorry, but the email address you supplied was invalid.

ATP1B1 - ATPase Na+/K+ transporting subunit beta 1 Gene

关于 ATP1B1

功能概要

ATP1B1 基因产物(1)

ATP1B1 蛋白结构

重组 ATP1B1 蛋白

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z