2. Gene
  3. Brca1 - BRCA1, DNA repair associated Gene

Brca1 - BRCA1, DNA repair associated Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

同用名: BRCA-1

基因 ID: 497672 | 基因类型: protein coding

关于 Brca1

功能概要

Enables chromatin binding activity. Involved in several processes, including positive regulation of protein import into nucleus; response to estradiol; and response to nutrient. Located in mitochondrial matrix. Biomarker of ductal carcinoma in situ. Human ortholog(s) of this gene implicated in several diseases, including breast Cancer (multiple); cervix uteri carcinoma in situ; gastrointestinal system Cancer (multiple); hereditary breast ovarian Cancer syndrome; and reproductive organ Cancer (multiple). Orthologous to human BRCA1 (BRCA1 DNA repair associated). [provided by Alliance of Genome Resources, Apr 2022]

Brca1 基因产物(1)

mRNA Protein Name
NM_012514.2 NP_036646.2 breast cancer type 1 susceptibility protein homolog
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables chromatin binding IDA
IDA: 通过直接分析推断
15574597 RGD
enables protein binding IPI
IPI: 通过物理相互作用推断
19074549 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in positive regulation of protein import into nucleus IMP
IMP: 通过突变表型推断
19074549 RGD
involved in response to estradiol IEP
IEP: 通过表达模式推断
14729590 RGD
involved in response to genistein IEP
IEP: 通过表达模式推断
14729590 RGD
involved in response to lipid IEP
IEP: 通过表达模式推断
17342305 RGD
involved in response to nutrient IEP
IEP: 通过表达模式推断
17044772 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in mitochondrial matrix IDA
IDA: 通过直接分析推断
15591126 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

breast cancer type 1 susceptibility protein homolog

RING-type E3 ubiquitin transferase BRCA1

breast cancer 1, early onset

相关产品

Approval
生物活性分子 (5)
目录号 产品名 作用方式
纯度 是否罕见病
HY-10617A Rucaparib Inhibitor 99.97% 是
HY-114778 Fluzoparib Inhibitor 99.85% 否
HY-10617 Rucaparib phosphate Inhibitor 99.76% 是
HY-102003 Rucaparib monocamsylate Inhibitor 99.82% 是
HY-102003A Rucaparib camsylate Inhibitor / 否
Clinical Phase
生物活性分子 (1)
目录号 产品名 作用方式
纯度 Phase
HY-115552 Simmiparib Inhibitor 99.51% Phase 1
Pre-clinical Phase
生物活性分子 (21)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-W327122 BAP1-IN-1 Inhibitor 99.83% 否
HY-124691 D-I03 Inhibitor 99.92% 否
HY-139156 SK-575 Inhibitor 99.51% 否
HY-126020 Bractoppin Inhibitor 99.70% 否
HY-100862 BRCA1-IN-2 Inhibitor 98.04% 否
HY-160700 TNG348 Inhibitor 99.74% 否
HY-162859 AB25583 99.85% 否
HY-139328 CDK12-IN-5 Inhibitor 99.01% 否
HY-139329 CDK12-IN-6 Inhibitor 98.09% 否
HY-RS01593 BRCA1 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-125010 Dicycloplatin Inducer / 否
HY-139327 CDK12-IN-4 Inhibitor / 否
HY-149003 PARP1-IN-10 / 否
HY-155246 PARP1-IN-15 / 否
HY-155766 PARP1-IN-14 / 否
HY-157212 PARP-1/Proteasome-IN-1 / 否
HY-162477 TS-24 98.96% 否
HY-162706 BSJ-5-63 Degrader / 否
HY-168094 PARP1-IN-30 Inhibitor / 否
HY-120750 A 62176 hydrochloride / 否
HY-100863 BRCA1-IN-1 Inhibitor / 否
抗体抑制剂 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-P990873 Anti-BRCA1 Antibody (BR64) Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Brca1 NCBI NCBI:672
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