2. Gene
  3. Nox4 - NADPH oxidase 4 Gene

Nox4 - NADPH oxidase 4 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：NADPH 氧化酶4

种属: Mus musculus

基因 ID: 50490 | 基因类型: protein coding

关于 Nox4

Chromosome 7: 86,895,304-87,047,918 forward strand.GRCm39:CM001000.3

This gene has 8 transcripts (splice variants), 149 orthologues, 5 paralogues and is associated with 31 phenotypes. Biased expression in kidney adult (RPKM 51.3) and lung adult (RPKM 5.1).

功能概要

该基因编码的蛋白可启动蛋白酪氨酸激酶结合活性和产生超氧化物的 NAD(P)H 氧化酶活性。参与多个过程，包括细胞内信号转导的正向调节；氮化合物代谢过程的正向调控；和超氧阴离子的产生。作用于骨吸收的上游或内部；心肌细胞分化；和细胞对葡萄糖刺激的反应。位于几种细胞成分中，包括线粒体；核;和细胞质的核周区。在胚胎中表达；心;后肾;肾皮质;和心室致密心肌。与人 NOX4（NADPH 氧化酶 4）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables protein tyrosine kinase binding activity and superoxide-generating NAD(P)H oxidase activity. Involved in several processes, including positive regulation of intracellular signal transduction; positive regulation of nitrogen compound metabolic process; and superoxide anion generation. Acts upstream of or within bone resorption; cardiac muscle cell differentiation; and cellular response to glucose stimulus. Located in several cellular components, including mitochondrion; nucleus; and perinuclear region of cytoplasm. Is expressed in embryo; heart; metanephros; renal cortex; and ventricle compact myocardium. Orthologous to human NOX4 (NADPH Oxidase 4). [provided by Alliance of Genome Resources, Apr 2022]

Nox4 基因产物(3)

mRNA Protein Name
NM_001285833.1 NP_001272762.1 NADPH oxidase 4 isoform 2
NM_001285835.1 NP_001272764.1 NADPH oxidase 4 isoform 3
NM_015760.5 NP_056575.1 NADPH oxidase 4 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein tyrosine kinase binding IPI
IPI: 通过物理相互作用推断
27525436 MGI
enables superoxide-generating NAD(P)H oxidase activity IMP
IMP: 通过突变表型推断
11098048 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within bone resorption IMP
IMP: 通过突变表型推断
11098048 MGI
acts upstream of or within cardiac muscle cell differentiation IMP
IMP: 通过突变表型推断
16775014 MGI
involved in cell morphogenesis IMP
IMP: 通过突变表型推断
10869423 MGI
involved in cellular response to glucose stimulus IEP
IEP: 通过表达模式推断
18431508 MGI
involved in heart process IGI
IGI: 通过遗传相互作用推断
27525436 MGI
involved in negative regulation of cell population proliferation IMP
IMP: 通过突变表型推断
10869423 MGI
involved in positive regulation of DNA biosynthetic process IMP
IMP: 通过突变表型推断
17942966 MGI
involved in positive regulation of ERK1 and ERK2 cascade IMP
IMP: 通过突变表型推断
17942966 MGI
involved in positive regulation of MAP kinase activity IMP
IMP: 通过突变表型推断
17942966 MGI
involved in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IMP
IMP: 通过突变表型推断
17942966 MGI
involved in positive regulation of protein tyrosine kinase activity IDA
IDA: 通过直接分析推断
27525436 MGI
involved in reactive oxygen species metabolic process IMP
IMP: 通过突变表型推断
17942966 MGI
involved in superoxide anion generation IDA
IDA: 通过直接分析推断
10869423 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cell periphery IDA
IDA: 通过直接分析推断
18431508 MGI
located in mitochondrion IDA
IDA: 通过直接分析推断
23624625 MGI
located in perinuclear region of cytoplasm IDA
IDA: 通过直接分析推断
18431508 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Nox4 蛋白结构

Ferric_reduct

Ferric_reduct: pfam01794 (68 - 204)

NOX_Duox_like_FAD_NADP

NOX_Duox_like_FAD_NADP: cd06186 (310 - 576)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 578 a.a.
蛋白主名 其他名称

NADPH oxidase 4

KOX-1

kidney oxidase-1

kidney superoxide-producing NADPH oxidase

renal NAD(P)H-oxidase

superoxide-generating NADPH oxidase 4

相关产品

Clinical Phase
生物活性分子 (3)
目录号 产品名 作用方式
纯度 Phase
HY-12298 Setanaxib Inhibitor 99.81% Phase 2
HY-120801 APX-115 Inhibitor 99.08% Phase 2
HY-120801A APX-115 free base Inhibitor 99.54% Phase 2
Pre-clinical Phase
生物活性分子 (8)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-100111 GLX351322 Inhibitor 99.48% 否
HY-101499 GKT136901 Inhibitor 99.70% 否
HY-101499A GKT136901 hydrochloride Inhibitor 99.90% 否
HY-152026 NADPH oxidase-IN-1 Inhibitor 99.69% 否
HY-N3239 Mulberrofuran G Inhibitor 99.84% 否
HY-105946 Hidrosmin Inhibitor / 否
HY-174818 NOX5-IN-2 Inhibitor / 否
HY-174817 NOX5-IN-1 Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Nox4 NCBI NCBI:50507
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