Smad4 - SMAD family member 4 Gene

种属: Rattus norvegicus

同用名: Madh4

关于 Smad4

功能概要

Enables DNA binding activity; SMAD binding activity; and filamin binding activity. Involved in several processes, including ERK1 and ERK2 cascade; cellular response to glucose stimulus; and positive regulation of cardiac muscle cell apoptotic process. Located in cytoplasm and nucleus. Part of protein-containing complex. Used to study pulmonary fibrosis. Biomarker of several diseases, including artery disease (multiple); gastrointestinal system Cancer (multiple); lung disease (multiple); prostatitis; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including female reproductive organ Cancer (multiple); hereditary hemorrhagic telangiectasia; juvenile polyposis syndrome; juvenile polyposis-hereditary hemorrhagic telangiectasia syndrome; and seminoma. Orthologous to human SMAD4 (Smad Family member 4). [provided by Alliance of Genome Resources, Apr 2022]