2. Gene
  3. Fbxw7 - F-box and WD-40 domain protein 7 Gene

Fbxw7 - F-box and WD-40 domain protein 7 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: AGO; Cdc4; Fbw7; Fbwd6; Fbx30; Fbxw6; Fbxo30; SEL-10; 1110001A17Rik

基因 ID: 50754 | 基因类型: protein coding

关于 Fbxw7

功能概要

Predicted to enable several functions, including cyclin binding activity; phosphothreonine residue binding activity; and ubiquitin protein Ligase binding activity. Involved in several processes, including SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; negative regulation of osteoclast development; and positive regulation of proteolysis involved in cellular protein catabolic process. Acts upstream of or within several processes, including negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding activity; protein destabilization; and vasculogenesis. Located in several cellular components, including Golgi apparatus; nucleolus; and perinuclear region of cytoplasm. Is expressed in brain; early conceptus; genitourinary system; and skeletal muscle tissue. Orthologous to human FBXW7 (F-box and WD repeat domain containing 7). [provided by Alliance of Genome Resources, Apr 2022]

Fbxw7 基因产物(3)

mRNA Protein Name
NM_001177773.1 NP_001171244.1 F-box/WD repeat-containing protein 7 isoform 1
NM_001177774.1 NP_001171245.1 F-box/WD repeat-containing protein 7 isoform 1
NM_080428.3 NP_536353.2 F-box/WD repeat-containing protein 7 isoform 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
11425854 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within Notch signaling pathway IDA
IDA: 通过直接分析推断
11425854 MGI
involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IDA
IDA: 通过直接分析推断
21953459 MGI
acts upstream of or within lung development IMP
IMP: 通过突变表型推断
21503901 MGI
involved in negative regulation of osteoclast development IMP
IMP: 通过突变表型推断
29149593 MGI
involved in positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway IMP
IMP: 通过突变表型推断
23858059 MGI
involved in positive regulation of proteasomal protein catabolic process IMP
IMP: 通过突变表型推断
23858059 MGI
involved in positive regulation of ubiquitin-dependent protein catabolic process IMP
IMP: 通过突变表型推断
27238018 MGI
involved in regulation of cell migration involved in sprouting angiogenesis IMP
IMP: 通过突变表型推断
23507969 MGI
involved in regulation of circadian rhythm IMP
IMP: 通过突变表型推断
27238018 MGI
acts upstream of or within vasculogenesis IMP
IMP: 通过突变表型推断
21503901 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in Golgi apparatus IDA
IDA: 通过直接分析推断
11735228 MGI
located in endoplasmic reticulum IDA
IDA: 通过直接分析推断
11735228 MGI
located in mitochondrion IDA
IDA: 通过直接分析推断
23858059 MGI
NOT located in nucleus IDA
IDA: 通过直接分析推断
11735228 MGI
located in nucleus IDA
IDA: 通过直接分析推断
20208556 MGI
located in perinuclear region of cytoplasm IDA
IDA: 通过直接分析推断
20208556 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

F-box/WD repeat-containing protein 7

F-box and WD-40 domain protein 7, archipelago homolog

F-box and WD-40 domain-containing protein 7

F-box-WD40 repeat protein 6

f-box only protein 30

相关产品

Pre-clinical Phase
生物活性分子 (4)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS04818 FBXW7 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-173082 10-SLF Degrader / 否
HY-RS17548 Fbxw7 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS24007 Fbxw7 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Fbxw7 NCBI NCBI:55294
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