2. Gene
  3. HERC5 - HECT and RLD domain containing E3 ubiquitin protein ligase 5 Gene

HERC5 - HECT and RLD domain containing E3 ubiquitin protein ligase 5 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品

中文名称：含 HECT 和 RLD 结构域的 E3 泛素蛋白连接酶 5

种属: Homo sapiens

同用名: CEB1; CEBP1

基因 ID: 51191 | 基因类型: protein coding

关于 HERC5

Cytogenetic location: 4q22.1 Genomic coordinates (GRCh38): 4:88,457,119-88,506,163 (from NCBI)

This gene has 5 transcripts (splice variants), 82 orthologues and 24 paralogues. Broad expression in testis (RPKM 31.7), endometrium (RPKM 6.3) and 17 other tissues.

功能概要

该基因是泛素连接酶 HERC 家族的成员，编码具有 HECT 结构域和五个 RCC1 重复序列的蛋白质。促炎细胞因子上调该基因在内皮细胞中的表达。该蛋白质定位于细胞质和核周区域，并作为干扰素诱导的 E3 蛋白连接酶发挥作用，介导蛋白质靶标的 ISGylation。该蛋白质还充当抗病毒免疫反应的调节剂。该基因位于 4 号染色体上的一组 HERC 家族基因中。[RefSeq 提供，2021 年 8 月]

This gene is a member of the HERC family of ubiquitin ligases and encodes a protein with a HECT domain and five RCC1 repeats. Pro-inflammatory cytokines upregulate expression of this gene in endothelial cells. The protein localizes to the cytoplasm and perinuclear region and functions as an interferon-induced E3 protein Ligase that mediates ISGylation of protein targets. The protein also acts as a modulator of the Antiviral immune response. The gene lies in a cluster of HERC family genes on chromosome 4. [provided by RefSeq, Aug 2021]

HERC5 基因产物(1)

mRNA Protein Name
NM_016323.4 NP_057407.2 E3 ISG15--protein ligase HERC5
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables ISG15 transferase activity IDA
IDA: 通过直接分析推断
16407192 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
20133869 GOA
enables ubiquitin protein ligase activity IDA
IDA: 通过直接分析推断
15331633 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in ISG15-protein conjugation IDA
IDA: 通过直接分析推断
16407192 GOA
involved in innate immune response IDA
IDA: 通过直接分析推断
28724761 GOA
acts upstream of or within protein ubiquitination IDA
IDA: 通过直接分析推断
15331633 GOA
involved in regulation of defense response to virus IDA
IDA: 通过直接分析推断
20308324 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
is active in cytoplasm IDA
IDA: 通过直接分析推断
16407192 GOA
located in cytoplasm IDA
IDA: 通过直接分析推断
10581175 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

HERC5 蛋白结构

RCC1

RCC1: Regulator of chromosome condensation (RCC1) repeat (157 - 206)

RCC1

RCC1: Regulator of chromosome condensation (RCC1) repeat (209 - 258)

RCC1

RCC1: Regulator of chromosome condensation (RCC1) repeat (261 - 309)

RCC1

RCC1: Regulator of chromosome condensation (RCC1) repeat (315 - 369)

HECT

HECT: HECT-domain (ubiquitin-transferase) (733 - 1024)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1024 a.a.
蛋白主名 其他名称

E3 ISG15--protein ligase HERC5

HECT domain and RCC1-like domain-containing protein 5

关联疾病

疾病名称 别名
Influenza

Flu

Influenza With Non-Respiratory Manifestation

Influenza With Other Manifestations

Influenza, Human

Influenza, Susceptibility To

Seasonal Influenza, Virus Identified
Dyskeratosis Congenita, Autosomal Recessive 5

Dyskeratosis Congenita, Autosomal Dominant, 4

DKCB5

Autosomal Dominant Dyskeratosis Congenita 4

DKCA4

Autosomal Recessive Dyskeratosis Congenita 5

Dyskeratosis Congenita, Autosomal Recessive, 5

Dyskeratosis Congenita, Autosomal Dominant 4

Dyskeratosis Congenita, Autosomal Recessive, Type 5
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS06130 HERC5 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS16311 Herc6 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
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