2. Gene
  3. PDE4C - phosphodiesterase 4C Gene

PDE4C - phosphodiesterase 4C Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：磷酸二酯酶 4C

种属: Homo sapiens

同用名: DPDE1; PDE21

基因 ID: 5143 | 基因类型: protein coding

关于 PDE4C

Cytogenetic location: 19p13.11 Genomic coordinates (GRCh38): 19:18,207,965-18,248,433 (from NCBI)

This gene has 14 transcripts (splice variants), 90 orthologues and 20 paralogues. Broad expression in placenta (RPKM 1.5), endometrium (RPKM 1.5) and 20 other tissues.

功能概要

该基因编码的蛋白质属于环核苷酸磷酸二酯酶 (PDE) 家族和 PDE4 亚家族。该 PDE 水解第二信使 cAMP，它是许多细胞对细胞外信号反应的调节剂和介体。因此，通过调节 cAMP 的细胞浓度，这种蛋白质在许多重要的生理过程中起着关键作用。已针对该基因描述了编码不同亚型的可变剪接转录物变体。[RefSeq 提供，2011 年 7 月]

The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE4 subfamily. This PDE hydrolyzes the second messenger, cAMP, which is a regulator and mediator of a number of cellular responses to extracellular signals. Thus, by regulating the cellular concentration of cAMP, this protein plays a key role in many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jul 2011]

PDE4C 基因产物(7)

mRNA Protein Name
NM_000923.6 NP_000914.2 cAMP-specific 3',5'-cyclic phosphodiesterase 4C isoform 1
NM_001098818.4 NP_001092288.1 cAMP-specific 3',5'-cyclic phosphodiesterase 4C isoform 3
NM_001098819.4 NP_001092289.1 cAMP-specific 3',5'-cyclic phosphodiesterase 4C isoform 2
NM_001330172.2 NP_001317101.1 cAMP-specific 3',5'-cyclic phosphodiesterase 4C isoform 1
NM_001369701.2 NP_001356630.1 cAMP-specific 3',5'-cyclic phosphodiesterase 4C isoform 4
NM_001395274.1 NP_001382203.1 cAMP-specific 3',5'-cyclic phosphodiesterase 4C isoform 2
NM_001414480.1 NP_001401409.1 cAMP-specific 3',5'-cyclic phosphodiesterase 4C isoform 1

PDE4C 蛋白结构

PDEase_I

PDEase_I: 3'5'-cyclic nucleotide phosphodiesterase (387 - 631)

  • 0
  • 200
  • 400
  • 600
  • 712 a.a.
蛋白主名 其他名称

cAMP-specific 3',5'-cyclic phosphodiesterase 4C

dunce-like phosphodiesterase E1

关联疾病

疾病名称 别名
Ocular Hypotension

Hypotony Of Eye
Retinitis Pigmentosa 73

RP73

Retinitis Pigmentosa, Type 73
Acrodysostosis

Acrodysplasia

Arkless-Graham Syndrome

Maroteaux-Malamut Syndrome

Nasal Hypoplasia-Peripheral Dysostosis-Intellectual Disability Syndrome

Peripheral Dysostosis-Nasal Hypoplasia-Intellectual Disability Syndrome
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (6)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-128358 MR-L2 Activator 99.23% 否
HY-119190 PF-06445974 Inhibitor 98.23% 否
HY-103050 ML-030 Inhibitor 99.50% 否
HY-100246 CI-1044 Inhibitor 98.03% 否
HY-131707 LEO 39652 Inhibitor 99.51% 否
HY-RS10224 PDE4C Human Pre-designed siRNA Set A / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus PDE4C VGNC VGNC:80650
Rattus norvegicus PDE4C RGD RGD:727918
Bos taurus PDE4C VGNC VGNC:50242
Canis familiaris PDE4C VGNC VGNC:49938
Mus musculus PDE4C MGD MGI:99556
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