2. Gene
  3. ASB2 - ankyrin repeat and SOCS box containing 2 Gene

ASB2 - ankyrin repeat and SOCS box containing 2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：含锚蛋白重复和 SOCS 盒 2

种属: Homo sapiens

同用名: ASB-2

基因 ID: 51676 | 基因类型: protein coding

关于 ASB2

Cytogenetic location: 14q32.12 Genomic coordinates (GRCh38): 14:93,934,166-93,976,570 (from NCBI)

This gene has 10 transcripts (splice variants), 1 gene allele, 211 orthologues and 2 paralogues. Biased expression in heart (RPKM 15.5), prostate (RPKM 8.6) and 12 other tissues.

功能概要

该基因编码锚蛋白重复序列和含 SOCS 盒 (ASB) 蛋白家族的成员。这些蛋白质通过将细胞因子信号传导 (SOCS) 抑制蛋白与 elongin BC 复合物偶联，在蛋白质降解中发挥作用。编码的蛋白质是介导肌动蛋白结合蛋白降解的多聚体 E3 泛素连接酶复合物的一个亚基。该基因在视黄酸诱导的骨髓性白血病细胞的生长抑制和分化中起作用。已经观察到该基因编码多种亚型的可变剪接转录物变体。[RefSeq 提供，2011 年 1 月]

This gene encodes a member of the ankyrin repeat and SOCS box-containing (ASB) protein family. These proteins play a role in protein degradation by coupling suppressor of cytokine signalling (SOCS) proteins with the elongin BC complex. The encoded protein is a subunit of a multimeric E3 ubiquitin Ligase complex that mediates the degradation of actin-binding proteins. This gene plays a role in retinoic acid-induced growth inhibition and differentiation of myeloid leukemia cells. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]

ASB2 基因产物(2)

mRNA Protein Name
NM_001202429.2 NP_001189358.1 ankyrin repeat and SOCS box protein 2 isoform 1
NM_016150.5 NP_057234.2 ankyrin repeat and SOCS box protein 2 isoform 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables cullin family protein binding IPI
IPI: 通过物理相互作用推断
21119685 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
16325183 GOA
contributes to ubiquitin protein ligase activity IDA
IDA: 通过直接分析推断
16325183 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cardiac muscle cell differentiation IMP
IMP: 通过突变表型推断
32179481 GOA
involved in proteasome-mediated ubiquitin-dependent protein catabolic process IMP
IMP: 通过突变表型推断
21119685 GOA
involved in protein ubiquitination IDA
IDA: 通过直接分析推断
16325183 GOA
involved in ubiquitin-dependent protein catabolic process IDA
IDA: 通过直接分析推断
24044920 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of ubiquitin ligase complex IDA
IDA: 通过直接分析推断
16325183 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ASB2 蛋白结构

Ank_4

Ank_4: Ankyrin repeats (many copies) (60 - 109)

Ank_2

Ank_2: Ankyrin repeats (3 copies) (130 - 220)

Ank_2

Ank_2: Ankyrin repeats (3 copies) (223 - 286)

Ank

Ank: Ankyrin repeat (288 - 309)

Ank

Ank: Ankyrin repeat (321 - 348)

Ank_2

Ank_2: Ankyrin repeats (3 copies) (367 - 453)

SOCS_box

SOCS_box: SOCS box (545 - 584)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 587 a.a.
蛋白主名 其他名称

ankyrin repeat and SOCS box protein 2

ankyrin repeat and SOCS box-containing protein 2a

关联疾病

疾病名称 别名
Myeloid Leukemia

Myeloid Leukaemia

Leukaemia Myelogenous

Leukemia Myelogenous

Myeloid Granulocytic Leukaemia

Myeloid Granulocytic Leukemia

Non-Lymphocytic Leukemia

Leukemia, Myeloid

Granulocytic Leukaemia

Myelogenous Leukaemia

Myeloid Leukaemia, Unspecified, Without Mention Of Remission
Acute Promyelocytic Leukemia

Leukemia, Acute Promyelocytic

Acute Myeloblastic Leukemia Type 3

Aml M3

APL

Leukemia, Acute Promyelocytic, Somatic

Aml With T(15

17)(Q22

Q12)

(Pml/Raralpha) And Variants

Apml

Acute Myeloblastic Leukemia 3

Acute Myeloid Leukemia With T(15

17)(Q22

Q12)

(Pml/Raralpha) And Variants

Acute Myeloblastic Leukaemia Type 3

Acute Myeloid Leukaemia M3

Acute Myeloid Leukemia M3

Acute Promyelocytic Leukaemia

M3 Anll

Myeloid Leukemia, Acute, M3

Leukemia Promyelocytic Acute

Leukemia, Promyelocytic, Acute

Leukemia, Acute, Promyelocytic
Leukemia, Acute Myeloid

Acute Myeloid Leukemia

Leukemia, Acute Myelogenous

Acute Myelogenous Leukemia

AML

Leukemia, Acute Myeloid, Susceptibility To

Acute Myeloblastic Leukemia

Leukemia, Acute Myeloid, Reduced Survival In, Somatic

Acute Myeloid Leukaemia

Leukemia, Myelocytic, Acute

Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome

Secondary Aml

Acute Myelocytic Leukemia

Acute Myeloid Leukemia, Somatic

Leukemia, Acute Myeloid, Somatic

Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic

Acute Myeloblastic Leukaemia

Acute Myelogenous Leukaemia

Aml - Acute Myeloid Leukemia

Acute Myeloid Leukemia With Cebpa Somatic Mutations

Aml With Cebpa Somatic Mutations

Inherited Acute Myeloid Leukemia

Familial Aml

Inherited Aml

Pure Familial Aml

Pure Familial Acute Myeloid Leukemia

Secondary Acute Myeloid Leukemia

Therapy-Related Aml And Myelodysplastic Syndrome

Acute Myeloid Leukemia, Secondary

Acute Non-Lymphoblastic Leukemia

Acute Non-Lymphocytic Leukemia

Acute Biphenotypic Leukemia

Acute Undifferentiated Leukemia

Acute Myeloblastic Leukaemia With Multilineage Dysplasia

Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission

Acute Myeloid Leukaemia With Myelodysplasia-Related Features
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (4)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-172399 FTO-IN-14 / 否
HY-RS01067 ASB2 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS22107 Asb2 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS28628 Asb2 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus ASB2 VGNC VGNC:59960
Canis familiaris ASB2 VGNC VGNC:38163
Macaca mulatta ASB2 VGNC VGNC:69840
Bos taurus ASB2 VGNC VGNC:26196
Mus musculus ASB2 MGD MGI:1929743
Rattus norvegicus ASB2 RGD RGD:1306414
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