Mefv - Mediterranean fever Gene

种属: Mus musculus

同用名: FMF; pyrin; TRIM20

关于 Mefv

功能概要

Predicted to enable actin binding activity; identical protein binding activity; and ubiquitin protein Ligase activity. Predicted to be involved in several processes, including negative regulation of NLRP3 inflammasome complex assembly; negative regulation of cytokine production; and pyroptosome complex assembly. Predicted to act upstream of or within immune system process. Predicted to be located in nucleus. Predicted to be part of microtubule associated complex. Predicted to be active in cytosol and nucleoplasm. Is expressed in bladder; female associated reproductive structure; ureter; and urethra of female. Used to study familial Mediterranean fever. Human ortholog(s) of this gene implicated in several diseases, including Henoch-Schoenlein purpura; Sweet syndrome; asthma; familial Mediterranean fever; and hematologic Cancer (multiple). Orthologous to human MEFV (MEFV innate immuity regulator, pyrin). [provided by Alliance of Genome Resources, Apr 2022]