2. Gene
  3. CHRNA9 - cholinergic receptor nicotinic alpha 9 subunit Gene

CHRNA9 - cholinergic receptor nicotinic alpha 9 subunit Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：胆碱能受体烟碱α9 亚单位

种属: Homo sapiens

同用名: NACHRA9; HSA243342

基因 ID: 55584 | 基因类型: protein coding

关于 CHRNA9

Cytogenetic location: 4p14 Genomic coordinates (GRCh38): 4:40,335,333-40,355,217 (from NCBI)

This gene has 3 transcripts (splice variants), 260 orthologues and 45 paralogues. Low expression observed in reference dataset.

功能概要

该基因是配体门控离子通道家族和烟碱乙酰胆碱受体基因超家族的成员。它编码形成同源或异源寡聚二价阳离子通道的质膜蛋白。这种蛋白质参与耳蜗毛细胞发育，也在成人耳蜗的外毛细胞 (OHC) 中表达。[RefSeq 提供，2012 年 2 月]

This gene is a member of the ligand-gated ionic channel family and nicotinic acetylcholine receptor gene superfamily. It encodes a plasma membrane protein that forms homo- or hetero-oligomeric divalent cation channels. This protein is involved in cochlea hair cell development and is also expressed in the outer hair cells (OHCs) of the adult cochlea. [provided by RefSeq, Feb 2012]

CHRNA9 基因产物(1)

mRNA Protein Name
NM_017581.4 NP_060051.2 neuronal acetylcholine receptor subunit alpha-9 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables acetylcholine-gated monoatomic cation-selective channel activity IDA
IDA: 通过直接分析推断
25282151 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
25282151 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within positive regulation of cytosolic calcium ion concentration IGI
IGI: 通过遗传相互作用推断
18420419 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of acetylcholine-gated channel complex IDA
IDA: 通过直接分析推断
25282151 GOA
located in plasma membrane IDA
IDA: 通过直接分析推断
25282151 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CHRNA9 蛋白结构

Neur_chan_LBD

Neur_chan_LBD: Neurotransmitter-gated ion-channel ligand binding domain (32 - 236)

Neur_chan_memb

Neur_chan_memb: Neurotransmitter-gated ion-channel transmembrane region (244 - 474)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 479 a.a.
蛋白主名 其他名称

neuronal acetylcholine receptor subunit alpha-9

NACHR alpha 9

CHRNA9 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属间
CHRNA9 Q9UGM1 3l21v_bunmu Bungarus multicinctus P60616
X-Ray Diffraction
25282151
种属间
CHRNA9 Q9UGM1 3l21v_bunmu Bungarus multicinctus P60616
Pull Down
25282151
种属间: 跨种属相互作用 种属内: 同种属相互作用

CHRNA9 抗体

目录号 产品名 应用 反应物种
HY-P81023 CHRNA9 Antibody WB, IHC-P Human, Rat

关联疾病

疾病名称 别名
Tobacco Addiction

Nicotine Dependence

Tobacco Addiction, Susceptibility To

Nicotine Addiction

Tobacco Use Disorder

Smoking Habit

Nicotine Dependence, Protection Against

Nicotine Addiction, Protection From

Cigarette Habituation

Cigarette Habituation, Susceptibility To

Smoking Habit, Susceptibility To

Nicotine Dependence, Susceptibility To

Nicotine Addiction, Susceptibility To

Addiction, Tobacco, Susceptibility To

Compulsive Tobacco User Syndrome

Tobacco Dependence

Tobacco Dependence Syndrome

Cigarette Addiction

Cigarette Dependence

Smoking Addiction

Smokers Syndrome
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS02673 CHRNA9 Human Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus CHRNA9 VGNC VGNC:27329
Canis familiaris CHRNA9 VGNC VGNC:39241
Felis catus CHRNA9 VGNC VGNC:78469
Macaca mulatta CHRNA9 VGNC VGNC:70947
Rattus norvegicus CHRNA9 RGD RGD:621534
Mus musculus CHRNA9 MGD MGI:1202403
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