2. Gene
  3. GSDMB - gasdermin B Gene

GSDMB - gasdermin B Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品

中文名称：gasdermin B

种属: Homo sapiens

同用名: GSDML; PP4052; GSDMB-1; PRO2521

基因 ID: 55876 | 基因类型: protein coding

关于 GSDMB

Cytogenetic location: 17q21.1 Genomic coordinates (GRCh38): 17:39,904,595-39,918,635 (from NCBI)

This gene has 15 transcripts (splice variants), 150 orthologues and 4 paralogues. Broad expression in small intestine (RPKM 18.8), duodenum (RPKM 16.9) and 17 other tissues.

功能概要

该基因编码含有 gasdermin 结构域的蛋白质家族成员。其他 gasdermin 家族基因与上皮细胞凋亡的调节有关，并与癌症有关。可变剪接和替代启动子的使用会导致多种转录本变体。已经描述了其他变体，但它们是无义介导的 mRNA 衰变 (NMD) 的候选者，不太可能是蛋白质编码的。[RefSeq 提供，2016 年 11 月]

This gene encodes a member of the gasdermin-domain containing protein family. Other gasdermin-family genes are implicated in the regulation of Apoptosis in epithelial cells, and are linked to Cancer. Alternative splicing and the use of alternative promoters results in multiple transcript variants. Additional variants have been described, but they are candidates for nonsense-mediated mRNA decay (NMD) and are unlikely to be protein-coding. [provided by RefSeq, Nov 2016]

GSDMB 基因产物(10)

mRNA Protein Name
NM_001042471.2 NP_001035936.1 gasdermin-B isoform 1
NM_001165958.2 NP_001159430.1 gasdermin-B isoform 3
NM_001165959.2 NP_001159431.1 gasdermin-B isoform 4
NM_001369402.2 NP_001356331.1 gasdermin-B isoform 1
NM_001388420.1 NP_001375349.1 gasdermin-B isoform 3
NM_001388421.1 NP_001375350.1 gasdermin-B isoform 4
NM_001388422.1 NP_001375351.1 gasdermin-B isoform 1
NM_001388423.1 NP_001375352.1 gasdermin-B isoform 2
NM_001388424.1 NP_001375353.1 gasdermin-B isoform 5
NM_018530.3 NP_061000.2 gasdermin-B isoform 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables cardiolipin binding IDA
IDA: 通过直接分析推断
34022140 GOA
enables phospholipid binding IDA
IDA: 通过直接分析推断
28154144 GOA
enables wide pore channel activity IDA
IDA: 通过直接分析推断
32299851 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cytotoxic T cell pyroptotic cell death IDA
IDA: 通过直接分析推断
28154144 GOA
involved in defense response to Gram-negative bacterium IDA
IDA: 通过直接分析推断
34022140 GOA
involved in granzyme-mediated programmed cell death signaling pathway IDA
IDA: 通过直接分析推断
32299851 GOA
involved in killing by host of symbiont cells IDA
IDA: 通过直接分析推断
34022140 GOA
NOT involved in pyroptotic inflammatory response IDA
IDA: 通过直接分析推断
36899106 GOA
involved in pyroptotic inflammatory response IDA
IDA: 通过直接分析推断
32299851 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
is active in plasma membrane IDA
IDA: 通过直接分析推断
28154144 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

GSDMB 蛋白结构

Gasdermin

Gasdermin: Gasdermin family (4 - 377)

  • 0
  • 100
  • 200
  • 300
  • 416 a.a.
蛋白主名 其他名称

gasdermin-B

gasdermin-like protein

关联疾病

疾病名称 别名
Oral Squamous Cell Carcinoma

Mouth Squamous Cell Carcinoma

Squamous Cell Carcinoma Of Mouth
Childhood-Onset Asthma

Childhood Asthma

Asthma Childhood
Chronic Asthma
Asthma

Chronic Obstructive Asthma

Asthma, Diminished Response To Antileukotriene Treatment In

Bronchial Hyperreactivity

Asthma, Susceptibility To

Asthma, Bronchial

Asthma, Protection Against

Asthma, Nocturnal, Susceptibility To

Nocturnal Asthma

Asthma-Related Traits

Asthma-Related Traits, Susceptibility To

Asthma, Nocturnal

Chronic Obstructive Asthma With Acute Exacerbation

Chronic Obstructive Asthma With Status Asthmaticus

Exercise Induced Asthma

Exercise-Induced Asthma

Bronchial Asthma

Asthma, Exercise-Induced

Idiosyncratic Asthma

Unspecified Asthma With Acute Exacerbation

Asthma, Unspecified, With Stated Status Asthmaticus

Status Asthmaticus Nos

Acute Severe Asthma

Acute Severe Bronchial Asthma

Status Asthma

Status Post Asthmaticus
Inflammatory Bowel Disease

Inflammatory Bowel Diseases

Bowel Disease, Inflammatory
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS05855 GSDMB Human Pre-designed siRNA Set A Pre-designed Sets / 否
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