2. Gene
  3. Samhd1 - SAM domain and HD domain, 1 Gene

Samhd1 - SAM domain and HD domain, 1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: Mg11; mSAMHD1; E330031J07Rik

基因 ID: 56045 | 基因类型: protein coding

关于 Samhd1

功能概要

Enables dGTPase activity. Involved in several processes, including dATP catabolic process; negative regulation of type I interferon-mediated signaling pathway; and protein homotetramerization. Predicted to be located in nucleoplasm; site of double-strand break; and tetraspanin-enriched microdomain. Predicted to be active in nucleus. Is expressed in left lung; right lung; and thymus primordium. Human ortholog(s) of this gene implicated in Aicardi-Goutieres syndrome; Chilblain lupus; acute myeloid leukemia; hepatitis B; and hepatitis C. Orthologous to human SAMHD1 (SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1). [provided by Alliance of Genome Resources, Apr 2022]

Samhd1 基因产物(3)

mRNA Protein Name
NM_001139520.2 NP_001132992.2 deoxynucleoside triphosphate triphosphohydrolase SAMHD1 isoform 2
NM_001370610.1 NP_001357539.1 deoxynucleoside triphosphate triphosphohydrolase SAMHD1 isoform 3
NM_018851.4 NP_061339.4 deoxynucleoside triphosphate triphosphohydrolase SAMHD1 isoform 1
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables dGTPase activity IDA
IDA: 通过直接分析推断
29379009 MGI
enables triphosphoric monoester hydrolase activity IDA
IDA: 通过直接分析推断
29379009 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in defense response to virus IMP
IMP: 通过突变表型推断
23972988 MGI
involved in negative regulation of type I interferon-mediated signaling pathway IMP
IMP: 通过突变表型推断
23972988 MGI
involved in protein homotetramerization IDA
IDA: 通过直接分析推断
29379009 MGI
involved in somatic hypermutation of immunoglobulin genes IMP
IMP: 通过突变表型推断
29669924 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

deoxynucleoside triphosphate triphosphohydrolase SAMHD1

IFN-gamma induced

SAM domain and HD domain-containing protein 1

dNTPase

interferon-gamma-inducible protein Mg11

相关产品

Pre-clinical Phase
生物活性分子 (10)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-B1299A Cephalosporin C zinc salt Inhibitor 99.31% 否
HY-161296 TH6342 Inhibitor 99.15% 否
HY-RS12433 SAMHD1 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-137613 Sp-TTPαS Inhibitor / 否
HY-137613A Sp-TTPαS tetrasodium Inhibitor / 否
HY-137618A Sp-dGTPαS tetrasodium / 否
HY-137618B Rp-dGTPαS / 否
HY-137619A Sp-dCTPαS tetrasodium / 否
HY-RS17783 Samhd1 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS24250 Samhd1 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Samhd1 NCBI NCBI:25939
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