2. Gene
  3. DNAJC3 - DnaJ heat shock protein family (Hsp40) member C3 Gene

DNAJC3 - DnaJ heat shock protein family (Hsp40) member C3 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：DnaJ 热休克蛋白家族 (Hsp40) 成员 C3

种属: Homo sapiens

同用名: P58; HP58; ACPHD; ERdj6; PRKRI; P58IPK; p58(IPK)

基因 ID: 5611 | 基因类型: protein coding

关于 DNAJC3

Cytogenetic location: 13q32.1 Genomic coordinates (GRCh38): 13:95,677,139-95,794,988 (from NCBI)

This gene has 2 transcripts (splice variants), 212 orthologues, 20 paralogues and is associated with 2 phenotypes. Ubiquitous expression in thyroid (RPKM 25.8), prostate (RPKM 15.3) and 25 other tissues.

功能概要

该基因编码的蛋白质具有多个四肽重复 (TPR) 基序以及在 DNAJ 伴侣家族成员中发现的高度保守的 J 结构域。它是四肽重复蛋白质家族的成员，可作为干扰素诱导的 dsRNA 激活蛋白激酶 (PKR) 的抑制剂。[RefSeq 提供，2010 年 7 月]

This gene encodes a protein with multiple tetratricopeptide repeat (TPR) motifs as well as the highly conserved J domain found in DNAJ chaperone family members. It is a member of the tetratricopeptide repeat family of proteins and acts as an inhibitor of the interferon-induced, dsRNA-activated protein kinase (PKR). [provided by RefSeq, Jul 2010]

DNAJC3 基因产物(1)

mRNA Protein Name
NM_006260.5 NP_006251.1 dnaJ homolog subfamily C member 3 precursor

DNAJC3 蛋白结构

TPR_11

TPR_11: TPR repeat (38 - 100)

TPR_1

TPR_1: Tetratricopeptide repeat (108 - 137)

TPR_11

TPR_11: TPR repeat (188 - 252)

TPR_11

TPR_11: TPR repeat (316 - 368)

DnaJ

DnaJ: DnaJ domain (394 - 459)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 504 a.a.
蛋白主名 其他名称

dnaJ homolog subfamily C member 3

DnaJ (Hsp40) homolog, subfamily C, member 3

关联疾病

疾病名称 别名
Ataxia, Combined Cerebellar And Peripheral, With Hearing Loss And Diabetes Mellitus

Juvenile-Onset Diabetes Mellitus-Central And Peripheral Neurodegeneration Syndrome

ACPHD

Combined Cerebellar And Peripheral Ataxia-Deafness-Diabetes Mellitus Syndrome

Combined Cerebellar And Peripheral Ataxia-Hearing Loss-Diabetes Mellitus Syndrome
Influenza

Flu

Influenza With Non-Respiratory Manifestation

Influenza With Other Manifestations

Influenza, Human

Influenza, Susceptibility To

Seasonal Influenza, Virus Identified
Epiphyseal Dysplasia, Multiple, With Early-Onset Diabetes Mellitus

Wolcott-Rallison Syndrome

Med-Iddm Syndrome

Iddm-Med Syndrome

Wolcott Rallison Syndrome

WRS

Epiphyseal Dysplasia Multiple With Early-Onset Diabetes Mellitus

Early-Onset Diabetes Mellitus With Multiple Epiphyseal Dysplasia

Multiple Epiphyseal Dysplasia With Early-Onset Diabetes Mellitus
Mehmo Syndrome

Mental Retardation, Epileptic Seizures, Hypogonadism And Hypogenitalism, Microcephaly, And Obesity

MEHMO

Mrxs20

Mrxs25

X-Linked Intellectual Disability-Epileptic Seizures-Hypogenitalism-Microcephaly-Obesity Syndrome

Mrxsbrk

Mental Retardation, X-Linked, Syndromic 20

Mental Retardation, X-Linked, Syndromic 25

Mental Retardation, X-Linked, Syndromic, Borck Type

Syndromic X-Linked Mental Retardation 20

Syndromic X-Linked Mental Retardation 25

Intellectual Disability, Epileptic Seizures, Hypogonadism And Hypogenitalism, Microcephaly, And Obesity

X-Linked Mehmo Syndrome
Diabetes Mellitus

Diabetes
Marinesco-Sjogren Syndrome

Marinesco-Sjögren Syndrome

MSS

Marinesco-Garland Syndrome

Garland-Moorhouse Syndrome

Hereditary Oligophrenic Cerebello-Lental Degeneration

Oligophrenic Cerebellolenticular Degeneration

Marinesco-Sjogren Syndrome-Hypergonadotrophic Hypogonadism

Marinesco-Sjogren Syndrome-Myopathy

Marinesco-Sjogren-Garland Syndrome

Marinesco-Sjoegren Syndrome
Lichtenstein-Knorr Syndrome

Scar19

LIKNS

Autosomal Recessive Spinocerebellar Ataxia 19

Spinocerebellar Ataxia, Autosomal Recessive 19

Progressive Autosomal Recessive Ataxia-Deafness Syndrome

Progressive Autosomal Recessive Ataxia-Sensorineural Hearing Loss Syndrome

Spinocerebellar Ataxia, Autosomal Recessive, 19
Wolfram Syndrome 1

WFS1

Didmoad

Wfs

Diabetes Mellitus And Insipidus With Optic Atrophy And Deafness

Diabetes Insipidus And Mellitus With Optic Atrophy And Deafness

Diabetes Insipidus And Mellitus With Optic Atrophy And Deafness Syndrome

Wolfram Syndrome
Wolfram Syndrome

Didmoad Syndrome

Didmoad

Diabetes Insipidus And Mellitus With Optic Atrophy And Deafness

Wfs

Diabetes Insipidus, Diabetes Mellitus, Optic Atrophy, And Deafness

Didmoadud

Diabetes Insipidus-Diabetes Mellitus-Optic Atrophy-Deafness Syndrome

Diabetes Insipidus-Diabetes Mellitus-Optic Atrophy-Hearing Loss Syndrome
Autosomal Dominant Severe Congenital Neutropenia

Severe Congenital Neutropenia Autosomal Dominant

Neutropenia, Congenital, Severe, Autosomal Dominant
Viral Infectious Disease

Viral Disease

Arbovirus Infections

Virus Infection

Virus Diseases

Viral Infection

Viral Infections

Virus Infections
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS03884 DNAJC3 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS21846 Dnajc3 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS28362 Dnajc3 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus DNAJC3 RGD RGD:708518
Macaca mulatta DNAJC3 VGNC VGNC:106259
Mus musculus DNAJC3 MGD MGI:107373
Felis catus DNAJC3 VGNC VGNC:102188
Bos taurus DNAJC3 VGNC VGNC:53813
Others DNAJC3 NCBI
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