2. Gene
  3. TDRD1 - tudor domain containing 1 Gene

TDRD1 - tudor domain containing 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：含 tudor 域 1

种属: Homo sapiens

同用名: CT41.1

基因 ID: 56165 | 基因类型: protein coding

关于 TDRD1

Cytogenetic location: 10q25.3 Genomic coordinates (GRCh38): 10:114,174,874-114,232,666 (from NCBI)

This gene has 4 transcripts (splice variants), 198 orthologues and 6 paralogues. Biased expression in testis (RPKM 8.5) and prostate (RPKM 0.6).

功能概要

该基因编码一种含有 tudor 结构域的蛋白质，该结构域被认为在精子发生过程中起到抑制转座因子的作用。小鼠中的相关蛋白与 piRNAs 和 Piwi 蛋白形成复合物，促进目标序列的甲基化和沉默。观察到该基因在前列腺肿瘤中被 ETS 转录因子 ERG 上调。[RefSeq 提供，2018 年 9 月]

This gene encodes a protein containing a tudor domain that is thought to function in the suppression of transposable elements during spermatogenesis. The related protein in mouse forms a complex with piRNAs and Piwi proteins to promote methylation and silencing of target sequences. This gene was observed to be upregulated by ETS transcription factor ERG in prostate tumors. [provided by RefSeq, Sep 2018]

TDRD1 基因产物(13)

mRNA Protein Name
NM_001365891.2 NP_001352820.1 tudor domain-containing protein 1 isoform 2
NM_001385363.1 NP_001372292.1 tudor domain-containing protein 1 isoform 1
NM_001385364.2 NP_001372293.1 tudor domain-containing protein 1 isoform 3
NM_001385365.1 NP_001372294.1 tudor domain-containing protein 1 isoform 4
NM_001385366.1 NP_001372295.1 tudor domain-containing protein 1 isoform 5
NM_001385367.1 NP_001372296.1 tudor domain-containing protein 1 isoform 6
NM_001385368.1 NP_001372297.1 tudor domain-containing protein 1 isoform 7
NM_001385369.1 NP_001372298.1 tudor domain-containing protein 1 isoform 7
NM_001385370.1 NP_001372299.1 tudor domain-containing protein 1 isoform 8
NM_001385371.1 NP_001372300.1 tudor domain-containing protein 1 isoform 9
NM_001385372.1 NP_001372301.1 tudor domain-containing protein 1 isoform 10
NM_001395205.1 NP_001382134.1 tudor domain-containing protein 1 isoform 3
NM_198795.2 NP_942090.1 tudor domain-containing protein 1 isoform 1
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
25416956 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

TDRD1 蛋白结构

zf-MYND

zf-MYND: MYND finger (170 - 206)

TUDOR

TUDOR: Tudor domain (261 - 382)

TUDOR

TUDOR: Tudor domain (492 - 611)

TUDOR

TUDOR: Tudor domain (712 - 831)

TUDOR

TUDOR: Tudor domain (937 - 1059)

  • 0
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  • 1000
  • 1189 a.a.
蛋白主名 其他名称

tudor domain-containing protein 1

cancer/testis antigen 41.1

关联疾病

疾病名称 别名
Spermatogenic Failure

Azoospermia

Spgf

Spermatogenic Failure, Susceptibility To

Absent Sperm

Aspermatogenesis

Infertility Due To Azoospermia

Hypospermatogenesis

Azoospermatism
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS14334 TDRD1 Human Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus TDRD1 MGD MGI:1933218
Canis familiaris TDRD1 VGNC VGNC:47220
Felis catus TDRD1 VGNC VGNC:66046
Macaca mulatta TDRD1 VGNC VGNC:78299
Rattus norvegicus TDRD1 RGD RGD:1306140
Bos taurus TDRD1 VGNC VGNC:35715
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