PSG9 - pregnancy specific beta-1-glycoprotein 9 Gene

中文名称：妊娠特异性 β-1-糖蛋白 9

种属: Homo sapiens

同用名: PS34; PSG11; PSGII; PSBG-9; PSBG-11

关于 PSG9

功能概要

由该基因编码的蛋白质是妊娠特异性糖蛋白 (PSG) 家族的成员。该蛋白家族和密切相关的癌胚抗原细胞粘附分子 (CEACAM) 基因家族都是免疫球蛋白超家族的成员，并且被组织成一个大的基因簇。这种蛋白质被认为可以抑制血小板-纤维蛋白原相互作用。几项研究表明，PSG 血清浓度降低与胎儿生长受限有关，而在结直肠癌中已观察到该基因的上调。在 19 号染色体上发现了该基因的几个假基因。可变剪接导致编码多种蛋白质亚型的多种转录物变体。[RefSeq 提供，2014 年 9 月]

The protein encoded by this gene is a member of the pregnancy-specific glycoprotein (PSG) family. This protein family and the closely related carcinoembryonic antigen cell adhesion molecule (CEACAM) gene family are both members of the immunoglobulin superfamily, and are organized as a large gene cluster. This protein is thought to inhibit platelet-fibrinogen interactions. Several studies suggest that reduced serum concentrations of PSGs are associated with fetal growth restrictions, while up-regulation of this gene has been observed in colorectal cancers. Several pseudogenes of this gene are found on chromosome 19. Alternative splicing results in multiple transcript variants that encode multiple protein isoforms. [provided by RefSeq, Sep 2014]