PTGER1 - prostaglandin E receptor 1 Gene

中文名称：前列腺素 E 受体 1

种属: Homo sapiens

同用名: EP1

关于 PTGER1

功能概要

该基因编码的蛋白质是 G 蛋白偶联受体家族的成员。这种蛋白质是前列腺素 E2 (PGE2) 的四种受体之一。通过磷脂酰肌醇-钙第二信使系统，GQ 蛋白介导该受体的活性。小鼠基因敲除研究表明该受体在调节痛觉和调节血压方面发挥作用。小鼠研究还表明，该基因可能介导促肾上腺皮质激素对细菌内毒素的反应。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene is a member of the G protein-coupled receptor family. This protein is one of four receptors identified for prostaglandin E2 (PGE2). Through a phosphatidylinositol-calcium second messenger system, G-Q proteins mediate this receptor's activity. Knockout studies in mice suggested a role of this receptor in mediating algesia and in regulation of blood pressure. Studies in mice also suggested that this gene may mediate adrenocorticotropic hormone response to Bacterial endotoxin. [provided by RefSeq, Jul 2008]