2. Gene
  3. Tk2 - thymidine kinase 2, mitochondrial Gene

Tk2 - thymidine kinase 2, mitochondrial Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: mt-TK

基因 ID: 57813 | 基因类型: protein coding

关于 Tk2

功能概要

Predicted to enable deoxycytidine kinase activity and thymidine kinase activity. Acts upstream of or within deoxyribonucleotide metabolic process; mitochondrial DNA metabolic process; and mitochondrial DNA replication. Located in mitochondrion. Used to study mitochondrial DNA depletion syndrome 2. Human ortholog(s) of this gene implicated in autosomal recessive progressive external ophthalmoplegia with mitochondrial DNA deletions 3 and mitochondrial DNA depletion syndrome 2. Orthologous to human TK2 (thymidine kinase 2). [provided by Alliance of Genome Resources, Apr 2022]

Tk2 基因产物(1)

mRNA Protein Name
NM_021028.3 NP_066356.3 thymidine kinase 2, mitochondrial precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables deoxycytidine kinase activity IDA
IDA: 通过直接分析推断
11023833 MGI
enables thymidine kinase activity IDA
IDA: 通过直接分析推断
11023833 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within deoxyribonucleotide metabolic process IMP
IMP: 通过突变表型推断
18467430 MGI
acts upstream of or within mitochondrial DNA metabolic process IMP
IMP: 通过突变表型推断
18467430 MGI
acts upstream of or within mitochondrial DNA replication IMP
IMP: 通过突变表型推断
18434326 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
is active in mitochondrion IDA
IDA: 通过直接分析推断
11023833 MGI
located in mitochondrion IDA
IDA: 通过直接分析推断
10571069 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

thymidine kinase 2, mitochondrial

2'-deoxyuridine kinase TK2

deoxycytidine kinase TK2

相关产品

Pre-clinical Phase
生物活性分子 (7)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-W008907 5'-O-Tritylthymidine 99.79% 否
HY-128710 2'-Fluorothymidine 99.07% 否
HY-RS14556 TK1 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS14557 TK2 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-W353804 2′-Deoxy-β-L-uridine / 否
HY-RS17628 Tk2 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS24088 Tk2 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Tk2 NCBI NCBI:7084
Macaca fascicularis Tk2 NCBI NCBI:102139352
Rattus norvegicus Tk2 NCBI NCBI:291824
Macaca mulatta Tk2 NCBI NCBI:693544
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