1. Gene
  2. RASGRF2 - Ras protein specific guanine nucleotide releasing factor 2 Gene

RASGRF2 - Ras protein specific guanine nucleotide releasing factor 2 Gene

中文名称:Ras 蛋白特异性鸟嘌呤核苷酸释放因子 2

种属: Homo sapiens

同用名: GRF2; RAS-GRF2

基因 ID: 5924 | 基因类型: protein coding

关于 RASGRF2

Cytogenetic location: 5q14.1 Genomic coordinates (GRCh38): 5:80,960,363-81,230,162 (from NCBI)

This gene has 6 transcripts (splice variants), 275 orthologues and 24 paralogues. Broad expression in brain (RPKM 9.6), ovary (RPKM 7.2) and 18 other tissues.

功能概要

Ras GTPases 在不活跃的 GDP 结合状态和活跃的 GTP 结合状态之间循环。该基因编码钙调节的核苷酸交换因子,通过将结合的 GDP 交换为 GTP,激活 RasRas 相关蛋白 RAC1,从而协调不同丝裂原活化蛋白激酶途径的信号传导。[RefSeq 提供,2011 年 10 月]

Ras GTPases cycle between an inactive GDP-bound state and an active GTP-bound state. This gene encodes a calcium-regulated nucleotide exchange factor activating both Ras and RAS-related protein, RAC1, through the exchange of bound GDP for GTP, thereby, coordinating the signaling of distinct mitogen-activated protein kinase pathways. [provided by RefSeq, Oct 2011]

RASGRF2 基因产物(1)

mRNA Protein Name
NM_006909.3 NP_008840.1 ras-specific guanine nucleotide-releasing factor 2
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables guanyl-nucleotide exchange factor activity IMP
IMP: 通过突变表型推断
27856453 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in response to endoplasmic reticulum stress IMP
IMP: 通过突变表型推断
27856453 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

RASGRF2 蛋白结构

PH

PH: PH domain (25 - 132)

RhoGEF

RhoGEF: RhoGEF domain (249 - 426)

RasGEF_N

RasGEF_N: RasGEF N-terminal motif (638 - 749)

RasGEF

RasGEF: RasGEF domain (1000 - 1184)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1000
  • 1237 a.a.
蛋白主名 其他名称

ras-specific guanine nucleotide-releasing factor 2

ras guanine nucleotide exchange factor 2

关联疾病

疾病名称 别名
Schizophrenia 12

Sczd12

Schizophrenia Susceptibility Locus, Chromosome 1p-Related

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Canis familiaris RASGRF2 VGNC VGNC:45371
Rattus norvegicus RASGRF2 RGD RGD:69413
Macaca mulatta RASGRF2 VGNC VGNC:84486
Felis catus RASGRF2 VGNC VGNC:69250
Bos taurus RASGRF2 VGNC VGNC:33746
Mus musculus RASGRF2 MGD MGI:109137