2. Gene
  3. Actn4 - actinin alpha 4 Gene

Actn4 - actinin alpha 4 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

基因 ID: 60595 | 基因类型: protein coding

关于 Actn4

功能概要

Enables actin filament binding activity. Involved in several processes, including bicellular tight junction assembly; positive regulation of pinocytosis; and protein localization to bicellular tight junction. Located in several cellular components, including Z disc; cytoskeleton; and pseudopodium. Is expressed in early conceptus and heart. Used to study focal segmental glomerulosclerosis 1. Human ortholog(s) of this gene implicated in focal segmental glomerulosclerosis and focal segmental glomerulosclerosis 1. Orthologous to human ACTN4 (actinin alpha 4). [provided by Alliance of Genome Resources, Apr 2022]

Actn4 基因产物(4)

mRNA Protein Name
NM_001360548.1 NP_001347477.1 alpha-actinin-4 isoform 2
NM_001360549.1 NP_001347478.1 alpha-actinin-4 isoform 3
NM_001360550.1 NP_001347479.1 alpha-actinin-4 isoform 4
NM_021895.3 NP_068695.1 alpha-actinin-4 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables actin filament binding IDA
IDA: 通过直接分析推断
15465019 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
12960352 MGI
enables structural constituent of cytoskeleton IMP
IMP: 通过突变表型推断
12782671 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in actin filament bundle assembly IDA
IDA: 通过直接分析推断
15841212 MGI
involved in bicellular tight junction assembly IMP
IMP: 通过突变表型推断
18332111 MGI
acts upstream of or within gene expression IMP
IMP: 通过突变表型推断
16501493 MGI
involved in glomerulus development IDA
IDA: 通过直接分析推断
12782671 MGI
involved in podocyte cell migration IMP
IMP: 通过突变表型推断
16837921 MGI
involved in positive regulation of pinocytosis IMP
IMP: 通过突变表型推断
10954430 MGI
involved in protein localization to bicellular tight junction IMP
IMP: 通过突变表型推断
18332111 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in Z disc IDA
IDA: 通过直接分析推断
20215401 MGI
located in cell-cell junction IDA
IDA: 通过直接分析推断
18332111 MGI
located in cortical actin cytoskeleton IDA
IDA: 通过直接分析推断
16837921 MGI
located in cortical cytoskeleton IDA
IDA: 通过直接分析推断
12960352 MGI
located in cytoplasm IDA
IDA: 通过直接分析推断
12960352 MGI
located in focal adhesion IDA
IDA: 通过直接分析推断
16837921 MGI
located in perinuclear region of cytoplasm IDA
IDA: 通过直接分析推断
33228246 MGI
located in pseudopodium IDA
IDA: 通过直接分析推断
15633123 MGI
colocalizes with stress fiber IDA
IDA: 通过直接分析推断
23890175 MGI
located in stress fiber IDA
IDA: 通过直接分析推断
15841212 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

alpha-actinin-4

F-actin cross-linking protein

non-muscle alpha-actinin 4

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS00226 ACTN4 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS20360 Actn4 Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS26869 Actn4 Rat Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Actn4 NCBI NCBI:81
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