SERPINB4 - serpin family B member 4 Gene

中文名称：serpin 家族 B 成员 4

种属: Homo sapiens

同用名: PI11; SCCA1; SCCA2; LEUPIN; SCCA-2

基因 ID: 6318 | 基因类型: protein coding

关于 SERPINB4

Cytogenetic location: 18q21.33 Genomic coordinates (GRCh38): 18:63,637,259-63,644,256 (from NCBI)

This gene has 4 transcripts (splice variants), 222 orthologues and 36 paralogues. Biased expression in esophagus (RPKM 63.1), urinary bladder (RPKM 11.6) and 1 other tissue.

功能概要

由该基因编码的蛋白质是丝氨酸蛋白酶抑制剂 Serpin 家族的成员。编码的蛋白质在许多肿瘤细胞中高度表达，可以使颗粒酶 M 失活，颗粒酶 M 是一种杀死肿瘤细胞的酶。这种蛋白质与 Serpin B3 一起可以加工成更小的片段，这些片段聚集形成牛皮癣中的自身抗原，可能是通过引起慢性炎症。[RefSeq 提供，2017 年 1 月]

The protein encoded by this gene is a member of the Serpin family of serine Protease Inhibitors. The encoded protein is highly expressed in many tumor cells and can inactivate granzyme M, an enzyme that kills tumor cells. This protein, along with Serpin B3, can be processed into smaller fragments that aggregate to form an autoantigen in psoriasis, probably by causing chronic inflammation. [provided by RefSeq, Jan 2017]

SERPINB4 基因产物(2)

mRNA	Protein	Name
NM_002974.4	NP_002965.1	serpin B4 isoform 1
NM_175041.2	NP_778206.1	serpin B4 isoform 2

基因本体论

分子功能
生物过程

分子功能 GO 注释	逻辑证据	参考文献	来源
enables enzyme binding	IPI IPI: 通过物理相互作用推断	23382074	GOA
enables protease binding	IPI IPI: 通过物理相互作用推断	21857942	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	28514442	GOA
enables serine-type endopeptidase inhibitor activity	IDA IDA: 通过直接分析推断	21857942	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in negative regulation of peptidase activity	IDA IDA: 通过直接分析推断	12949073	GOA
involved in protection from natural killer cell mediated cytotoxicity	IMP IMP: 通过突变表型推断	21857942	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SERPINB4 蛋白结构

Serpin

0
100
200
300
390 a.a.

蛋白主名

其他名称

serpin B4

SCCA2/SCCA1 fusion protein

SERPINB4 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	SERPINB4	P48594	SERPINB3	Homo sapiens	P29508	Anti Tag CoIP	33961781

种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 SERPINB4 蛋白

目录号	产品名	蛋白编号	纯度
HY-P77198	Serpin B4 Protein, Human (sf9, His)	P48594 (M1-P390)	≥95%

关联疾病

疾病名称

别名

Squamous Cell Carcinoma

Epidermoid Carcinoma	Squamous Cell Cancer
Carcinoma, Squamous Cell	Squamous Cell Skin Cancer
Malignant Squamous Cell Tumor	Squamous Carcinoma
Squamous Cell Epithelioma	Carcinoma Squamous Cell
Neoplasms, Squamous Cell	Squamous Cell Carcinoma - Category
Malignant Squamous Cell Neoplasm	Squamous Cell Carcinoma Of Skin

Maxillary Sinus Inverted Papilloma

Inverted Papilloma Of The Maxillary Sinus

Maxillary Sinus Benign Neoplasm

Neoplasm Of Maxillary Sinus	Tumor Of Maxillofacial Sinus
Maxillary Sinus Neoplasms	Maxillary Sinus Neoplasm

Psoriasis

Acute Frontal Sinusitis

Cervical Squamous Cell Carcinoma

Squamous Cell Carcinoma Of The Cervix Uteri

Squamous Cell Carcinoma Of Cervix

Childhood Central Nervous System Primitive Neuroectodermal Neoplasm

Pediatric Cns Pnet

Childhood Central Nervous System Primitive Neuroectodermal Tumor

Cervical Cancer

Cervical Cancer, Somatic	Neoplasm Of Uterine Cervix
Cervix Cancer	Uterine Cervical Neoplasm
Cervical Neoplasm	Cervix Uteri Cancer
Tumor Of The Cervix Uteri	CERCA
Uterine Cervical Cancer	Neoplasms Cervical
Uterine Cervical Neoplasms	Cervical Cancers
Cancer, Cervical, Somatic	Malignant Tumor Of Cervix
Cervix Carcinoma

Asthma

Chronic Obstructive Asthma	Asthma, Diminished Response To Antileukotriene Treatment In
Bronchial Hyperreactivity	Asthma, Susceptibility To
Asthma, Bronchial	Asthma, Protection Against
Asthma, Nocturnal, Susceptibility To	Nocturnal Asthma
Asthma-Related Traits	Asthma-Related Traits, Susceptibility To
Asthma, Nocturnal	Chronic Obstructive Asthma With Acute Exacerbation
Chronic Obstructive Asthma With Status Asthmaticus	Exercise Induced Asthma
Exercise-Induced Asthma	Bronchial Asthma
Asthma, Exercise-Induced	Idiosyncratic Asthma
Unspecified Asthma With Acute Exacerbation	Asthma, Unspecified, With Stated Status Asthmaticus
Status Asthmaticus Nos	Acute Severe Asthma
Acute Severe Bronchial Asthma	Status Asthma
Status Post Asthmaticus

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS12712	SERPINB4 Human Pre-designed siRNA Set A	Pre-designed Set	/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	SERPINB4	RGD	RGD:1562868

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

SERPINB4 - serpin family B member 4 Gene

关于 SERPINB4

功能概要

SERPINB4 基因产物(2)

SERPINB4 蛋白结构

SERPINB4 蛋白互作信息

重组 SERPINB4 蛋白

关联疾病

直系同源

热门区域

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SERPINB4 - serpin family B member 4 Gene

关于 SERPINB4

功能概要

SERPINB4 基因产物(2)

SERPINB4 蛋白结构

SERPINB4 蛋白互作信息

重组 SERPINB4 蛋白

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z