2. Gene
  3. GREM2 - gremlin 2, DAN family BMP antagonist Gene

GREM2 - gremlin 2, DAN family BMP antagonist Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：gremlin 2，DAN 家族 BMP 拮抗因子

种属: Homo sapiens

同用名: PRDC; DAND3; STHAG9; CKTSF1B2

基因 ID: 64388 | 基因类型: protein coding

关于 GREM2

Cytogenetic location: 1q43 Genomic coordinates (GRCh38): 1:240,489,573-240,612,155 (from NCBI)

This gene has 1 transcript (splice variant), 204 orthologues, 2 paralogues and is associated with 1 phenotype. Broad expression in gall bladder (RPKM 20.4), colon (RPKM 11.9) and 14 other tissues.

功能概要

该基因编码 BMP (骨形态发生蛋白) 拮抗剂家族的成员。与 BMP 一样，BMP 拮抗剂含有胱氨酸结，通常形成同二聚体和异二聚体。该基因所属的 BMP 拮抗剂的 CAN (cerberus 和 dan) 亚家族的特征在于具有八元环的 C 末端胱氨酸结。由该基因编码的分泌型糖基化蛋白的拮抗作用可能是由于它直接与 BMP 蛋白结合。作为 BMP 的拮抗剂，该基因可能在调节器官发生、身体形态和组织分化中发挥作用。[RefSeq 提供，2008 年 7 月]

This gene encodes a member of the BMP (bone morphogenic protein) antagonist family. Like BMPs, BMP antagonists contain cystine knots and typically form homo- and heterodimers. The CAN (cerberus and dan) subfamily of BMP antagonists, to which this gene belongs, is characterized by a C-terminal cystine knot with an eight-membered ring. The antagonistic effect of the secreted glycosylated protein encoded by this gene is likely due to its direct binding to BMP proteins. As an antagonist of BMP, this gene may play a role in regulating organogenesis, body patterning, and tissue differentiation. [provided by RefSeq, Jul 2008]

GREM2 基因产物(1)

mRNA Protein Name
NM_022469.4 NP_071914.3 gremlin-2 precursor

GREM2 蛋白结构

DAN

DAN: DAN domain (48 - 161)

  • 0
  • 100
  • 168 a.a.
蛋白主名 其他名称

gremlin-2

DAN domain family member 3

关联疾病

疾病名称 别名
Tooth Agenesis, Selective, 9

STHAG9
Tooth Agenesis

Oligodontia

Hypodontia

Selective Tooth Agenesis

Tooth Agenesis, Selective

Familial Tooth Agenesis

Anodontia

Congenital Absence Of One Tooth
Sclerosteosis

Cortical Hyperostosis With Syndactyly

Sost

Cortical Hyperostosis-Syndactyly Syndrome
Scleral Staphyloma

Scleral Ectasia

Staphyloma Of Sclera
Hereditary Mixed Polyposis Syndrome

Hmps
Anodontia

Complete Absence Of Teeth

Developmental Absence Of Tooth

Total Anodontia Of Permanent And Deciduous Teeth

Absence Of Permanent Teeth

Anodontia Of Permanent Dentition

Agomphiasis

Agomphosis

Anodontism

Complete Developmental Absence Of Teeth

Congenital Absence Of Teeth

Congenital Complete Absence Of Teeth

Congenital Edentia

Absence Of Teeth

Absent Teeth

Congenital Partial Absence Of Teeth

Partial Absence Of Teeth

Partial Anodontia
Syngnathia

Cleft Palate-Lateral Synechia Syndrome

Cpls Syndrome

Cleft Palate Lateral Synechia Syndrome
Synostoses, Tarsal, Carpal, And Digital

Calcaneonavicular Coalition

Multiple Synostosis Syndrome

Synostoses, Tarsal, Carpal And Digital
Osteoporosis

Postmenopausal Osteoporosis

Osteoporosis, Postmenopausal

Bone Mineral Density Quantitative Trait Locus

Bmnd

Osteoporosis, Involutional

Osteoporosis, Susceptibility To

Osteoporosis, Postmenopausal, Susceptibility

Bone Mineral Density Variation Qtl, Osteoporosis

OSTEOP

Involutional Osteoporosis

Senile Osteoporosis

Osteoporosis Postmenopausal

Bone Mineral Density, Quantitative Trait Locus

Osteoporosis, Senile

Idiopathic Osteoporosis

Bone Rarefaction Nos

Type 1 Osteoporosis
Familial Atrial Fibrillation

Atrial Fibrillation, Familial

Atfb

Atrial Fibrillation Autosomal Dominant

Autosomal Dominant Atrial Fibrillation

Auricular Fibrillation

Atrial Fibrillation

Atrial Fibrillation, Familial, 1
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS05785 GREM2 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS20945 Grem2 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS27462 Grem2 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris GREM2 VGNC VGNC:41475
Rattus norvegicus GREM2 RGD RGD:1560008
Mus musculus GREM2 MGD MGI:1344367
Macaca mulatta GREM2 VGNC VGNC:106377
Felis catus GREM2 VGNC VGNC:107878
Others GREM2 NCBI
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