2. Gene
  3. SLC22A3 - solute carrier family 22 member 3 Gene

SLC22A3 - solute carrier family 22 member 3 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：溶质载体家族 22 成员 3

种属: Homo sapiens

同用名: EMT; EMTH; OCT3

基因 ID: 6581 | 基因类型: protein coding

关于 SLC22A3

Cytogenetic location: 6q25.3 Genomic coordinates (GRCh38): 6:160,348,378-160,452,577 (from NCBI)

This gene has 1 transcript (splice variant), 527 orthologues and 22 paralogues. Biased expression in liver (RPKM 29.4), prostate (RPKM 6.3) and 10 other tissues.

功能概要

肝脏、肾脏、肠道和其他器官中的多特异性有机阳离子转运蛋白对于消除许多内源性小有机阳离子以及多种药物和环境毒素至关重要。该基因是位于 6 号染色体簇中的三个相似阳离子转运蛋白基因之一。编码的蛋白质包含十二个假定的跨膜结构域，是一种血浆整合膜蛋白。[RefSeq 提供，2008 年 7 月]

Polyspecific organic cation transporters in the liver, kidney, intestine, and Other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. This gene is one of three similar cation transporter genes located in a cluster on chromosome 6. The encoded protein contains twelve putative transmembrane domains and is a plasma integral membrane protein. [provided by RefSeq, Jul 2008]

SLC22A3 基因产物(1)

mRNA Protein Name
NM_021977.4 NP_068812.1 solute carrier family 22 member 3
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables monoamine transmembrane transporter activity IDA
IDA: 通过直接分析推断
10196521 GOA
enables monoamine transmembrane transporter activity IMP
IMP: 通过突变表型推断
23505051 GOA
enables neurotransmitter transmembrane transporter activity IDA
IDA: 通过直接分析推断
10196521 GOA
enables neurotransmitter transmembrane transporter activity IMP
IMP: 通过突变表型推断
23505051 GOA
enables organic cation transmembrane transporter activity EXP
EXP: 通过实验结果推断
19141712 GOA
enables organic cation transmembrane transporter activity IDA
IDA: 通过直接分析推断
10966924 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
17474147 GOA
enables quaternary ammonium group transmembrane transporter activity IDA
IDA: 通过直接分析推断
10966924 GOA
enables toxin transmembrane transporter activity IDA
IDA: 通过直接分析推断
22806583 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular detoxification IDA
IDA: 通过直接分析推断
22806583 GOA
involved in dopamine transport IDA
IDA: 通过直接分析推断
16581093 GOA
involved in dopamine uptake IDA
IDA: 通过直接分析推断
20858707 GOA
involved in epinephrine transport IDA
IDA: 通过直接分析推断
10196521 GOA
involved in epinephrine uptake IDA
IDA: 通过直接分析推断
20858707 GOA
involved in histamine transport IDA
IDA: 通过直接分析推断
16581093 GOA
involved in histamine uptake IDA
IDA: 通过直接分析推断
20858707 GOA
involved in histamine uptake IMP
IMP: 通过突变表型推断
23505051 GOA
involved in monoamine transport IMP
IMP: 通过突变表型推断
23505051 GOA
involved in neurotransmitter transport IDA
IDA: 通过直接分析推断
20858707 GOA
involved in norepinephrine transport IDA
IDA: 通过直接分析推断
10196521 GOA
involved in norepinephrine uptake IDA
IDA: 通过直接分析推断
20858707 GOA
acts upstream of or within organic cation transport IDA
IDA: 通过直接分析推断
10966924 GOA
involved in organic cation transport IDA
IDA: 通过直接分析推断
22806583 GOA
acts upstream of or within quaternary ammonium group transport IDA
IDA: 通过直接分析推断
10966924 GOA
involved in quaternary ammonium group transport IDA
IDA: 通过直接分析推断
20858707 GOA
involved in serotonin transport IDA
IDA: 通过直接分析推断
10196521 GOA
involved in serotonin uptake IDA
IDA: 通过直接分析推断
20858707 GOA
involved in xenobiotic transport IDA
IDA: 通过直接分析推断
20858707 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in apical plasma membrane IDA
IDA: 通过直接分析推断
15817714 GOA
located in basolateral plasma membrane IDA
IDA: 通过直接分析推断
15817714 GOA
located in plasma membrane IDA
IDA: 通过直接分析推断
20858707 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SLC22A3 蛋白结构

MFS_1

MFS_1: Major Facilitator Superfamily (159 - 485)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 556 a.a.
蛋白主名 其他名称

solute carrier family 22 member 3

EMT organic cation transporter 3

SLC22A3 抗体

目录号 产品名 应用 反应物种
HY-P83085 SLC22A3 Antibody (YA2830) WB, IHC-P, FC Human

关联疾病

疾病名称 别名
Type 1 Diabetes Mellitus 8

Diabetes Mellitus, Insulin-Dependent, 8

Iddm8

Insulin-Dependent Diabetes Mellitus 8

T1D8

Insulin-Dependent Diabetes Mellitus-8
Extragonadal Seminoma

Primary Extragonadal Seminoma
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS13074 SLC22A3 Human Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus SLC22A3 VGNC VGNC:34727
Mus musculus SLC22A3 MGD MGI:1333817
Macaca mulatta SLC22A3 VGNC VGNC:77418
Canis familiaris SLC22A3 VGNC VGNC:46278
Felis catus SLC22A3 VGNC VGNC:65245
Rattus norvegicus SLC22A3 RGD RGD:3701
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