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  3. SPIB - Spi-B transcription factor Gene

SPIB - Spi-B transcription factor Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：Spi-B 转录因子

种属: Homo sapiens

同用名: SPI-B

基因 ID: 6689 | 基因类型: protein coding

关于 SPIB

Cytogenetic location: 19q13.33 Genomic coordinates (GRCh38): 19:50,418,938-50,431,314 (from NCBI)

This gene has 8 transcripts (splice variants), 99 orthologues, 28 paralogues and is associated with 1 phenotype. Biased expression in lymph node (RPKM 17.1), appendix (RPKM 10.5) and 7 other tissues.

功能概要

该基因编码的蛋白质是一种转录激活因子，可与 PU-box (5'-GAGGAA-3') 结合并充当淋巴特异性增强子。已发现该基因编码不同亚型的四种转录变体。[RefSeq 提供，2011 年 9 月]

The protein encoded by this gene is a transcriptional activator that binds to the PU-box (5'-GAGGAA-3') and acts as a lymphoid-specific enhancer. Four transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]

SPIB 基因产物(4)

mRNA Protein Name
NM_001243998.2 NP_001230927.1 transcription factor Spi-B isoform 2
NM_001243999.2 NP_001230928.1 transcription factor Spi-B isoform 3
NM_001244000.2 NP_001230929.2 transcription factor Spi-B isoform 4
NM_003121.5 NP_003112.2 transcription factor Spi-B isoform 1
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables DNA-binding transcription activator activity, RNA polymerase II-specific IMP
IMP: 通过突变表型推断
10196196 GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IMP
IMP: 通过突变表型推断
10196196 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
32814053 GOA
enables sequence-specific double-stranded DNA binding IDA
IDA: 通过直接分析推断
28473536 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: 通过突变表型推断
10196196 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SPIB 蛋白结构

Ets

Ets: Ets-domain (169 - 253)

  • 0
  • 100
  • 200
  • 262 a.a.
蛋白主名 其他名称

transcription factor Spi-B

Spi-B transcription factor (Spi-1/PU.1 related)

SPIB 抗体

目录号 产品名 应用 反应物种
HY-P84464 SPIB Antibody (YA4161) WB, IHC-P, ICC/IF, FC, ELISA Human, Mouse

关联疾病

疾病名称 别名
Primary Biliary Cholangitis

Primary Biliary Cirrhosis

Biliary Liver Cirrhosis

Chronic Nonsuppurative Destructive Cholangitis

Familial Primary Biliary Cirrhosis

Pbc

Hanot Syndrome

Cholestatic Cirrhosis

Biliary Cirrhosis Primary

Liver Cirrhosis, Biliary

Hanot'S Cirrhosis

Biliary Cirrhosis

Pericholangiolic Biliary Cirrhosis

Tannhauser-Magendantz Syndrome

Hanot-Rossle Syndrome

Hypertrophic Cirrhosis

Todd Cirrhosis

Hanot Cirrhosis

Charcot Cirrhosis

Mahon-Tannhauser Syndrome

Toxic Cirrhosis

Hypertrophic Biliary Cirrhosis

Monolobular Cirrhosis

Unilobar Cirrhosis

Xanthomatous Biliary Cirrhosis
Burkitt Lymphoma

Burkitt'S Lymphoma

BL

Burkitt Lymphoma, Somatic

Burkitt Lymphoma/Leukaemia

Burkitt'S Tumor

Burkitt'S Tumor Or Lymphoma

Malignant Lymphoma, Burkitt'S Type

Small Non-Cleaved Cell Lymphoma, Burkitt'S Type

Small Non-Cleaved Cell Lymphoma

Burkitt Tumor

Burkitts Lymphoma

Lymphoma, Small Noncleaved-Cell

Burkitt Tumour

Diffuse Small Noncleaved Malignant Burkitt Lymphoma

Malignant Burkitt Lymphoma

“Burkitt-Like” Lymphoma

Undifferentiated Burkitt Lymphoma

Small Noncleaved Cell Burkitt Lymphoma
Mcd Diffuse Large B-Cell Lymphoma

Mcd Dlbcl

Doid:0081066
Pitt-Hopkins Syndrome

PTHS

Encephalopathy, Severe Epileptic, With Autonomic Dysfunction

Mental Retardation, Syndromal, With Intermittent Hyperventilation

Intellectual Disability, Wide Mouth, Distinctive Facial Features, And Intermittent Hyperventilation Followed By Apnea

Pitt Hopkins Syndrome

Phs

Encephalopathy Severe Epileptic With Autonomic Dysfunction
Progressive Multifocal Leukoencephalopathy

Pml

Leukoencephalopathy, Progressive Multifocal

Progressive Multifocal Leukoencephalitis

Leukoencephalopathy Progressive Multifocal

Pml - [Progressive Multifocal Leukoencephalopathy]
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS13672 SPIB Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS22331 Spib Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS28853 Spib Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus SPIB MGD MGI:892986
Rattus norvegicus SPIB RGD RGD:1565899
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