2. Gene
  3. Edem3 - ER degradation enhancer, mannosidase alpha-like 3 Gene

Edem3 - ER degradation enhancer, mannosidase alpha-like 3 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: 2310050N11Rik

基因 ID: 66967 | 基因类型: protein coding

关于 Edem3

功能概要

Enables mannosyl-oligosaccharide 1,2-alpha-mannosidase activity. Involved in mannose trimming involved in glycoprotein ERAD pathway. Acts upstream of or within glycoprotein catabolic process and proteasome-mediated ubiquitin-dependent protein catabolic process. Located in endoplasmic reticulum lumen. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation type II. Orthologous to human EDEM3 (ER degradation enhancing alpha-mannosidase like protein 3). [provided by Alliance of Genome Resources, Apr 2022]

Edem3 基因产物(3)

mRNA Protein Name
NM_001039644.2 NP_001034733.2 ER degradation-enhancing alpha-mannosidase-like protein 3 isoform 1 precursor
NM_001311165.1 NP_001298094.1 ER degradation-enhancing alpha-mannosidase-like protein 3 isoform 2 precursor
NM_001311166.1 NP_001298095.1 ER degradation-enhancing alpha-mannosidase-like protein 3 isoform 3 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables mannosyl-oligosaccharide 1,2-alpha-mannosidase activity IDA
IDA: 通过直接分析推断
16431915 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in ERAD pathway IDA
IDA: 通过直接分析推断
16431915 MGI
acts upstream of or within glycoprotein catabolic process IDA
IDA: 通过直接分析推断
16431915 MGI
involved in mannoprotein catabolic process IDA
IDA: 通过直接分析推断
16431915 MGI
acts upstream of or within proteasome-mediated ubiquitin-dependent protein catabolic process IDA
IDA: 通过直接分析推断
16431915 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in endoplasmic reticulum lumen IDA
IDA: 通过直接分析推断
16431915 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

ER degradation-enhancing alpha-mannosidase-like protein 3

ER degradation-enhancing alpha-mannosidase-like 3

alpha-1,2-mannosidase EDEM3

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS04159 EDEM3 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS22479 Edem3 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS29002 Edem3 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Edem3 NCBI NCBI:80267
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