SYN2 - synapsin II Gene

中文名称：突触素 II

种属: Homo sapiens

同用名: SYNII

基因 ID: 6854 | 基因类型: protein coding

关于 SYN2

Cytogenetic location: 3p25.2 Genomic coordinates (GRCh38): 3:12,004,388-12,192,032 (from NCBI)

This gene has 6 transcripts (splice variants), 221 orthologues, 2 paralogues and is associated with 1 phenotype. Biased expression in brain (RPKM 41.0) and fat (RPKM 5.3).

功能概要

该基因是突触蛋白基因家族的成员。突触蛋白编码与突触小泡的细胞质表面相关的神经元磷蛋白。家族成员的特征是共同的蛋白质结构域，它们与突触发生和神经递质释放的调节有关，表明它们在多种神经精神疾病中具有潜在作用。突触蛋白家族的这个成员编码一种神经元特异性磷蛋白，它选择性地结合突触前神经末梢的小突触囊泡。该基因的多态性与异常的突触前功能和相关的神经元疾病有关，包括自闭症、癫痫、双相情感障碍和精神分裂症。该基因的可变剪接导致多个转录变体。金属蛋白酶 4 基因的组织抑制剂位于该基因的一个内含子内，并以相反的方向转录。[RefSeq 提供，2014 年 2 月]

This gene is a member of the synapsin gene family. Synapsins encode neuronal phosphoproteins which associate with the cytoplasmic surface of synaptic vesicles. Family members are characterized by common protein domains, and they are implicated in synaptogenesis and the modulation of neurotransmitter release, suggesting a potential role in several neuropsychiatric diseases. This member of the synapsin family encodes a neuron-specific phosphoprotein that selectively binds to small synaptic vesicles in the presynaptic nerve terminal. Polymorphisms in this gene are associated with abnormal presynaptic function and related neuronal disorders, including autism, epilepsy, bipolar disorder and schizophrenia. Alternative splicing of this gene results in multiple transcript variants. The tissue inhibitor of metalloproteinase 4 gene is located within an intron of this gene and is transcribed in the opposite direction. [provided by RefSeq, Feb 2014]

SYN2 基因产物(2)

mRNA	Protein	Name
NM_003178.6	NP_003169.2	synapsin-2 isoform IIb
NM_133625.6	NP_598328.1	synapsin-2 isoform IIa

基因本体论

分子功能

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	23406870	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

蛋白主名

其他名称

synapsin-2

SYN2 抗体

目录号	产品名	应用	反应物种
HY-P82153	Synapsin 2 Antibody (YA1898)	WB, IHC-P	Human, Mouse, Rat

关联疾病

疾病名称

别名

Schizophrenia

SCZD	Schizophrenia With Or Without An Affective Disorder
Schizophrenia 12	Schizophrenia, Susceptibility To
Schizophrenia-1	Dementia Praecox
Schizophrenia 1

Bipolar Disorder

Bipolar Depression	Manic Disorder
Depression, Bipolar	Bipolar Disorder Manic Phase
Depressive-Manic Psych.	Manic Bipolar Affective Disorder
Manic Bipolar I Disorder	Manic Depression
Manic Depressive Disorder	Mixed Bipolar Disorder
Bipolar Affective Disorder	Bipolar Affective Psychosis
Bipolar Spectrum Disorder	Manic Depressive Illness
Depression Bipolar	Bipolar Disorder, Mixed
Major Affective Disorder	Major Affective Disorder 1
Major Affective Disorder 2

Psychotic Disorder

Psychotic Disorders	Mental Or Behavioural Disorder
Psychotic	Mental Disorders

Epilepsy, X-Linked, With Variable Learning Disabilities And Behavior Disorders

X-Linked Epilepsy-Learning Disabilities-Behavior Disorders Syndrome	EPILX
X-Linked Epilepsy With Variable Learning Disabilities And Behavior Disorders	Epilepsy, X-Linked, With Reflex Bathing Seizures
Bathing Epilepsy, X-Linked

Epilepsy

Epilepsy Syndrome	Epileptic Syndrome
Epilepsies	Symptomatic Epilepsies
Post Traumatic Epilepsy	Traumatic Epilepsy
Traumatic Epileptic	Epilepsy Due To Hippocampal Sclerosis
Epilepsy With Ammon'S Horn Sclerosis	Epilepsy Due To Cortical Dysplasia
Epilepsy Due To Neuronal Migration Disorders

Persian Gulf Syndrome

Gulf War Syndrome

Autism

Autistic Disorder	Autism Susceptibility 1
Childhood Autism	Autistic Disorder Of Childhood Onset
Infantile Autism	Kanner'S Syndrome
Autistic

Schizoaffective Disorder

Schizo-Affective Psychosis	Schizo-Affective Type Schizophrenia
Schizoaffective Psychosis	Schizoaffective Schizophrenia
Schizophrenia, Schizo-Affective Type	Schizophreniform Psychosis, Affective Type

Methemoglobinemia And Ambiguous Genitalia

METAG	Methemoglobinemia Type Iv
Isolated 17,20-Lyase Deficiency, Pure	Methemoglobinemia Due To Deficiency Of Cytochrome B5
Methemoglobinemia Type 4	Methemoglobinemia Type Iv, Formerly
Methemoglobinemia Due To Deficiency Of Cytochrome B5, Formerly	Pure Isolated 17,20-Lyase Deficiency
Methemoglobinemia, Type Iv

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS14080	SYN2 Human Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS18975	Stx2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	否

直系同源

种属	基因名	来源	基因 ID
Macaca mulatta	SYN2	VGNC	VGNC:78065
Canis familiaris	SYN2	VGNC	VGNC:54371
Rattus norvegicus	SYN2	RGD	RGD:3798
Felis catus	SYN2	VGNC	VGNC:65879
Mus musculus	SYN2	MGD	MGI:103020
Bos taurus	SYN2	VGNC	VGNC:35515

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站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

SYN2 - synapsin II Gene

关于 SYN2

功能概要

SYN2 基因产物(2)

SYN2 抗体

关联疾病

直系同源

热门区域

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SYN2 - synapsin II Gene

关于 SYN2

功能概要

SYN2 基因产物(2)

SYN2 抗体

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z