2. Gene
  3. TBCC - tubulin folding cofactor C Gene

TBCC - tubulin folding cofactor C Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：微管蛋白折叠辅因子 C

种属: Homo sapiens

同用名: CFC

基因 ID: 6903 | 基因类型: protein coding

关于 TBCC

Cytogenetic location: 6p21.1 Genomic coordinates (GRCh38): 6:42,744,498-42,746,103 (from NCBI)

This gene has 1 transcript (splice variant) and 166 orthologues.

功能概要

辅因子 C 是四种蛋白质 (辅因子 A、D、E 和 C) 之一，参与从折叠中间体正确折叠 β-微管蛋白的途径。辅因子 A 和 D 被认为在捕获和稳定 β-微管蛋白中间体中发挥作用，这在准天然证实中发挥了作用。辅因子 E 与辅因子 D/β-微管蛋白复合物结合；然后与辅因子 C 的相互作用会导致释放处于天然状态的 β-微管蛋白多肽。[RefSeq 提供，2008 年 7 月]

Cofactor C is one of four proteins (cofactors A, D, E, and C) involved in the pathway leading to correctly folded beta-tubulin from folding intermediates. Cofactors A and D are believed to play a role in capturing and stabilizing beta-tubulin intermediates in a quasi-native confirmation. Cofactor E binds to the cofactor D/beta-tubulin complex; interaction with cofactor C then causes the release of beta-tubulin polypeptides that are committed to the native state. [provided by RefSeq, Jul 2008]

TBCC 基因产物(1)

mRNA Protein Name
NM_003192.3 NP_003183.2 tubulin-specific chaperone C
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables GTPase activity IDA
IDA: 通过直接分析推断
11847227 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
32814053 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in post-chaperonin tubulin folding pathway IDA
IDA: 通过直接分析推断
11847227 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
12417528 GOA
located in photoreceptor connecting cilium IDA
IDA: 通过直接分析推断
12417528 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

TBCC 蛋白结构

TBCC

TBCC: Tubulin binding cofactor C (204 - 321)

  • 0
  • 100
  • 200
  • 300
  • 346 a.a.
蛋白主名 其他名称

tubulin-specific chaperone C

TBCC 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
TBCC Q15814 FGFR3 Homo sapiens P22607
Validated Y2H
32814053
种属内
TBCC Q15814 FGFR3 Homo sapiens P22607
Y2H Array
32814053
种属内
TBCC Q15814 FGFR3 Homo sapiens P22607
Y2H Pooling
32814053
种属内
TBCC Q15814 GSN Homo sapiens P06396
Validated Y2H
32814053
种属内
TBCC Q15814 GSN Homo sapiens P06396
Y2H Array
32814053
种属内
TBCC Q15814 GSN Homo sapiens P06396
Y2H Pooling
32814053
种属间: 跨种属相互作用 种属内: 同种属相互作用

TBCC 抗体

目录号 产品名 应用 反应物种
HY-P84602 TBCC Antibody (YA4299) IHC-P, ICC/IF, ELISA Human

关联疾病

疾病名称 别名
Retinitis Pigmentosa 2

RP2

X-Linked Retinitis Pigmentosa 2

Xlrp2

Xlrp-2

Retinitis Pigmentosa-2

Retinitis Pigmentosa, Type 2
Quadriplegia

Tetraplegia

Tetraplegias
Kenny-Caffey Syndrome

Kenny Syndrome
Leukodystrophy, Hypomyelinating, 6

Habc

Hypomyelinating Leukodystrophy 6

HLD6

H-Abc

Hypomyelination With Atrophy Of Basal Ganglia And Cerebellum

Leukodystrophy, Hypomyelinating, With Atrophy Of The Basal Ganglia And Cerebellum

Hypomyelinating Leukodystrophy With Atrophy Of The Basal Ganglia And Cerebellum

HLD

Leukodystrophy, Hypomyelinating, Type 6
Short-Rib Thoracic Dysplasia 3 With Or Without Polydactyly

Asphyxiating Thoracic Dystrophy 3

Saldino-Noonan Syndrome

SRTD3

Atd3

Srps1

Srps3

Verma-Naumoff Syndrome

Srps2b

Short Rib-Polydactyly Syndrome, Verma-Naumoff Type

Short Rib-Polydactyly Syndrome, Type I

Polydactyly With Neonatal Chondrodystrophy, Type I

Polydactyly With Neonatal Chondrodystrophy, Type Iii

Short Rib-Polydactyly Syndrome, Type Iib

Short Rib-Polydactyly Syndrome Type 3

Polydactyly With Neonatal Chondrodystrophy Type Iii

Short Rib-Polydactyly Syndrome Type Iii

Short Rib-Polydactyly Syndrome Type 1

Short Rib-Polydactyly Syndrome, Saldino-Noonan Type

Majewski Syndrome

Short Rib-Polydactyly Syndrome, Type Iii

Type I Short Rib Polydactyly Syndrome

Srps Type 3

Short Rib Polydactyly Syndrome Verma Naumoff Type

Verma Naumoff Syndrome

Polydactyly With Neonatal Chondrodystrophy Type 1

Srps Type 1

Short Rib-Polydactyly Syndrome Saldino-Noonan Type

Jatd

Jeune Asphyxiating Thoracic Dystrophy

Jeune Syndrome 3

Polydactyly With Neonatal Chondrodystrophy Type I

Short Rib-Polydactyly Syndrome Type I

Short Rib-Polydactyly Syndrome Type Iib

Srps Type Iib

Srps Type Iii
Short-Rib Thoracic Dysplasia 12

Beemer-Langer Syndrome

Type Iv Short Rib Polydactyly Syndrome

Short Rib-Polydactyly Syndrome Type 4

Short Rib-Polydactyly Syndrome, Beemer Type

SRTD12

Short Rib-Polydactyly Syndrome, Type Iv

Srps4

Srps Iv

Short Rib Syndrome, Beemer Type

Beemer Langer Syndrome

Srps Type 4

Short Rib Polydactyly Syndrome Beemer-Langer Type

Short Rib-Polydactyly Syndrome Beemer Type

Short Rib-Polydactyly Syndrome Type Iv

Short Rib-Polydactyly Syndrome, Beemer-Langer Type
Retinitis Pigmentosa

RP

Rod-Cone Dystrophy

Autosomal Recessive Retinitis Pigmentosa

Non-Syndromic Retinitis Pigmentosa

Pericentral Pigmentary Retinopathy

Pigmentary Retinopathy

Tapetoretinal Degeneration

Rcd

Retinitis Pigmentosa Autosomal Recessive

ARRP

Retinitis Pigmentosa, Autosomal Recessive

Retinitis Pigmentosa 1
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS14252 TBCC Human Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus TBCC VGNC VGNC:35650
Macaca mulatta TBCC VGNC VGNC:78105
Mus musculus TBCC MGD MGI:1919976
Felis catus TBCC VGNC VGNC:65993
Canis familiaris TBCC VGNC VGNC:47154
Rattus norvegicus TBCC RGD RGD:1306756
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