2. Gene
  3. Spink2 - serine peptidase inhibitor, Kazal type 2 Gene

Spink2 - serine peptidase inhibitor, Kazal type 2 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: HUSI-II; 1700007F22Rik

基因 ID: 69982 | 基因类型: protein coding

关于 Spink2

功能概要

Predicted to enable serine-type endopeptidase inhibitor activity. Involved in acrosome assembly. Acts upstream of or within several processes, including gamete generation; negative regulation of serine-type endopeptidase activity; and seminiferous tubule development. Located in acrosomal vesicle and neuron projection. Is expressed in intestine; male reproductive gland or organ; oviduct; skin; and tongue. Human ortholog(s) of this gene implicated in spermatogenic failure 29. Orthologous to human SPINK2 (serine peptidase inhibitor Kazal type 2). [provided by Alliance of Genome Resources, Apr 2022]

Spink2 基因产物(4)

mRNA Protein Name
NM_001289764.2 NP_001276693.2 serine protease inhibitor Kazal-type 2 isoform 1
NM_001289767.1 NP_001276696.1 serine protease inhibitor Kazal-type 2 isoform 3
NM_001289768.1 NP_001276697.1 serine protease inhibitor Kazal-type 2 isoform 4 precursor
NM_183284.3 NP_899107.1 serine protease inhibitor Kazal-type 2 isoform 2 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
31146259 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in acrosome assembly IMP
IMP: 通过突变表型推断
28554943 MGI
acts upstream of or within fertilization IMP
IMP: 通过突变表型推断
21705336 MGI
acts upstream of or within male germ cell proliferation IMP
IMP: 通过突变表型推断
21705336 MGI
acts upstream of or within male gonad development IMP
IMP: 通过突变表型推断
21705336 MGI
acts upstream of or within negative regulation of serine-type endopeptidase activity IDA
IDA: 通过直接分析推断
21705336 MGI
acts upstream of or within positive regulation of apoptotic process IDA
IDA: 通过直接分析推断
24699552 MGI
acts upstream of or within seminiferous tubule development IMP
IMP: 通过突变表型推断
21705336 MGI
acts upstream of or within spermatid development IMP
IMP: 通过突变表型推断
21705336 MGI
involved in spermatid development IMP
IMP: 通过突变表型推断
28554943 MGI
acts upstream of or within spermatogenesis IMP
IMP: 通过突变表型推断
21705336 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in acrosomal vesicle IDA
IDA: 通过直接分析推断
21705336 MGI
located in cytoplasm IDA
IDA: 通过直接分析推断
21705336 MGI
located in neuron projection IDA
IDA: 通过直接分析推断
24699552 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

serine protease inhibitor Kazal-type 2

acrosin-trypsin inhibitor

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS13680 SPINK2 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS20600 Spink2 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS27108 Spink2 Rat Pre-designed siRNA Set A Pre-designed Set / 否
抗体抑制剂 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-P991676 Eflumenibep alfa Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Spink2 NCBI NCBI:6691
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