2. Gene
  3. Prdm16 - PR domain containing 16 Gene

Prdm16 - PR domain containing 16 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: csp1; mel1; 5730557K01Rik

基因 ID: 70673 | 基因类型: protein coding

关于 Prdm16

功能概要

Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; Histone Methyltransferase activity (H3-K9 specific); and transcription coactivator activity. Involved in several processes, including brown fat cell differentiation; positive regulation of cold-induced thermogenesis; and regulation of transcription, DNA-templated. Acts upstream of or within several processes, including negative regulation of transforming growth factor beta receptor signaling pathway; positive regulation of brown fat cell differentiation; and tongue development. Located in nucleus. Part of transcription repressor complex. Is expressed in several structures, including alimentary system; branchial arch; central nervous system; embryo mesenchyme; and sensory organ. Orthologous to human PRDM16 (PR/SET domain 16). [provided by Alliance of Genome Resources, Apr 2022]

Prdm16 基因产物(4)

mRNA Protein Name
NM_001177995.1 NP_001171466.1 histone-lysine N-methyltransferase PRDM16 isoform 2
NM_001291026.1 NP_001277955.1 histone-lysine N-methyltransferase PRDM16 isoform 3
NM_001291029.1 NP_001277958.1 histone-lysine N-methyltransferase PRDM16 isoform 4
NM_027504.3 NP_081780.3 histone-lysine N-methyltransferase PRDM16 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
IDA: 通过直接分析推断
28930673 MGI
enables SMAD binding IPI
IPI: 通过物理相互作用推断
17467076 MGI
enables histone H3K9 methyltransferase activity IDA
IDA: 通过直接分析推断
22939622 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
17467076 MGI
enables sequence-specific DNA binding IDA
IDA: 通过直接分析推断
17618855 MGI
enables transcription coactivator activity IDA
IDA: 通过直接分析推断
17618855 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in brown fat cell differentiation IDA
IDA: 通过直接分析推断
18483224 MGI
acts upstream of brown fat cell differentiation IMP
IMP: 通过突变表型推断
24703692 MGI
involved in brown fat cell differentiation IMP
IMP: 通过突变表型推断
17618855 MGI
involved in heterochromatin organization IMP
IMP: 通过突变表型推断
22939622 MGI
involved in negative regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
18483224 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IMP
IMP: 通过突变表型推断
24703692 MGI
acts upstream of or within negative regulation of transforming growth factor beta receptor signaling pathway IMP
IMP: 通过突变表型推断
20007998 MGI
acts upstream of or within neurogenesis IDA
IDA: 通过直接分析推断
19050759 MGI
acts upstream of or within positive regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
28930673 MGI
involved in positive regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
18483224 MGI
acts upstream of or within positive regulation of brown fat cell differentiation IMP
IMP: 通过突变表型推断
24703692 MGI
involved in positive regulation of cold-induced thermogenesis IMP
IMP: 通过突变表型推断
24439384 MGI
involved in regulation of cellular respiration IDA
IDA: 通过直接分析推断
17618855 MGI
acts upstream of or within roof of mouth development IMP
IMP: 通过突变表型推断
20007998 MGI
acts upstream of or within somatic stem cell population maintenance IDA
IDA: 通过直接分析推断
19379700 MGI
acts upstream of or within stem cell population maintenance IGI
IGI: 通过遗传相互作用推断
24703692 MGI
acts upstream of or within stem cell population maintenance IMP
IMP: 通过突变表型推断
24703692 MGI
acts upstream of or within tongue development IMP
IMP: 通过突变表型推断
20007998 MGI
involved in white fat cell differentiation IDA
IDA: 通过直接分析推断
18483224 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in nucleus IDA
IDA: 通过直接分析推断
18483224 MGI
part of transcription repressor complex IDA
IDA: 通过直接分析推断
18483224 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

histone-lysine N-methyltransferase PRDM16

MDS1/EVI1-like gene 1

PR domain zinc finger protein 16

PR domain-containing protein 16

line 27

transcription factor MEL1

相关产品

Pre-clinical Phase
生物活性分子 (5)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-119790 Palmitoyllactic acid Agonist / 否
HY-177467 P0064 / 否
HY-RS11066 PRDM16 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS19522 Prdm16 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS26017 Prdm16 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Prdm16 NCBI NCBI:63976
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