1. Gene
  2. NKX2-1 - NK2 homeobox 1 Gene

NKX2-1 - NK2 homeobox 1 Gene

中文名称:NK2 同源框 1

种属: Homo sapiens

同用名: BCH; BHC; NK-2; TEBP; TTF1; NKX2A; NMTC1; T/EBP; TITF1; TTF-1; NKX2.1

基因 ID: 7080 | 基因类型: protein coding

关于 NKX2-1

Cytogenetic location: 14q13.3 Genomic coordinates (GRCh38): 14:36,516,397-36,520,232 (from NCBI)

This gene has 4 transcripts (splice variants), 204 orthologues, 13 paralogues and is associated with 76 phenotypes. Biased expression in lung (RPKM 35.0) and thyroid (RPKM 29.1).

功能概要

该基因编码的蛋白质最初被确定为甲状腺特异性转录因子。编码的蛋白质与甲状腺球蛋白启动子结合并调节甲状腺特异性基因的表达,但也被证明可以调节参与形态发生的基因的表达。该基因的突变和缺失与良性遗传性舞蹈病、舞蹈手足徐动症、先天性甲状腺功能减退症和新生儿呼吸窘迫有关,并可能与甲状腺癌有关。已发现该基因编码不同异构体的多个转录变体。该基因与另一个基因 (转录终止因子 1) 共享符号/别名“TTF1”,后者在核糖体基因转录中发挥作用。[RefSeq 提供,2014 年 2 月]

This gene encodes a protein initially identified as a thyroid-specific transcription factor. The encoded protein binds to the thyroglobulin promoter and regulates the expression of thyroid-specific genes but has also been shown to regulate the expression of genes involved in morphogenesis. Mutations and deletions in this gene are associated with benign hereditary chorea, choreoathetosis, congenital hypothyroidism, and neonatal respiratory distress, and may be associated with thyroid Cancer. Multiple transcript variants encoding different isoforms have been found for this gene. This gene shares the symbol/alias 'TTF1' with another gene, transcription termination factor 1, which plays a role in ribosomal gene transcription. [provided by RefSeq, Feb 2014]

NKX2-1 基因产物(2)

mRNA Protein Name
NM_001079668.3 NP_001073136.1 homeobox protein Nkx-2.1 isoform 1
NM_003317.4 NP_003308.1 homeobox protein Nkx-2.1 isoform 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables DNA binding IMP
IMP: 通过突变表型推断
7635972 GOA
enables DNA-binding transcription factor activity IDA
IDA: 通过直接分析推断
7559607 GOA
enables DNA-binding transcription factor activity IMP
IMP: 通过突变表型推断
19176457 GOA
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
IDA: 通过直接分析推断
23143308 GOA
enables RNA polymerase II-specific DNA-binding transcription factor binding IPI
IPI: 通过物理相互作用推断
17220277 GOA
enables enzyme binding IPI
IPI: 通过物理相互作用推断
23382074 GOA
enables intronic transcription regulatory region sequence-specific DNA binding IDA
IDA: 通过直接分析推断
23143308 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
11152647 GOA
enables transcription cis-regulatory region binding IDA
IDA: 通过直接分析推断
1735431 GOA
enables transcription cis-regulatory region binding IMP
IMP: 通过突变表型推断
19176457 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in brain development IMP
IMP: 通过突变表型推断
11971878 GOA
involved in epithelial tube branching involved in lung morphogenesis IEP
IEP: 通过表达模式推断
8675988 GOA
involved in forebrain development IEP
IEP: 通过表达模式推断
15494458 GOA
involved in globus pallidus development IMP
IMP: 通过突变表型推断
11854319 GOA
involved in lung development IEP
IEP: 通过表达模式推断
15494458 GOA
involved in negative regulation of cell migration IDA
IDA: 通过直接分析推断
19293183 GOA
involved in negative regulation of epithelial to mesenchymal transition IDA
IDA: 通过直接分析推断
19293183 GOA
acts upstream of or within negative regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
23143308 GOA
involved in negative regulation of transforming growth factor beta receptor signaling pathway IDA
IDA: 通过直接分析推断
19293183 GOA
involved in positive regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
14960358 GOA
involved in positive regulation of DNA-templated transcription IMP
IMP: 通过突变表型推断
19176457 GOA
involved in positive regulation of gene expression IDA
IDA: 通过直接分析推断
16960125 GOA
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
7559607 GOA
involved in regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
25060702 GOA
involved in response to hormone IEP
IEP: 通过表达模式推断
16960125 GOA
involved in thyroid gland development IEP
IEP: 通过表达模式推断
15494458 GOA
involved in thyroid gland development IMP
IMP: 通过突变表型推断
11854319 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in nucleus IDA
IDA: 通过直接分析推断
7713914 GOA
part of transcription regulator complex IPI
IPI: 通过物理相互作用推断
25060702 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

NKX2-1 蛋白结构

Homeobox

Homeobox: Homeobox domain (192 - 248)

  • 0
  • 100
  • 200
  • 300
  • 401 a.a.
蛋白主名 其他名称

homeobox protein Nkx-2.1

NK-2 homolog A

NKX2-1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
NKX2-1 P43699 CCDC59 Homo sapiens Q9P031
Y2H
11152647
种属内
NKX2-1 P43699 CCDC59 Homo sapiens Q9P031 11152647
种属内
NKX2-1 P43699 NCK1 Homo sapiens P16333 17474147
种属间: 跨种属相互作用 种属内: 同种属相互作用

NKX2-1 抗体

目录号 产品名 应用 反应物种
HY-P82552 Thyroid Transcription Factor 1 Antibody (YA2297) WB, ICC/IF Human, Hamster
HY-P85945 TTF-1 Antibody (YA5637) IHC-P, WB, ICC/IF, ELISA Human, Mouse, Rat,
HY-P86155 TTF1 Antibody (YA5847) WB, IHC-P, ICC/IF, IP, ELISA Human, Mouse, Rat
HY-P86917 TTF1 Antibody(YA6610) mIHC Mouse

关联疾病

疾病名称 别名
Chorea, Benign Hereditary

Benign Hereditary Chorea

BHC

Chorea, Hereditary Benign

Benign Familial Chorea

Bch

Hereditary Progressive Chorea Without Dementia

Chorea Familial Benign

Hereditary Chorea Without Dementia

Chorea Benign Hereditary

Bche Deficiency

Chorea, Hereditary, Benign

Chorea, Benign Familial

Choreoathetosis And Congenital Hypothyroidism With Or Without Pulmonary Dysfunction

Brain-Lung-Thyroid Syndrome

Choreoathetosis, Hypothyroidism, And Neonatal Respiratory Distress

CAHTP

Blt Syndrome

Choreoathetosis-Hypothyroidism-Neonatal Respiratory Distress Syndrome

Choreoathetosis-Hypothyroidism-Neonatal Respiratory Distress

Brain-Thyroid-Lung Syndrome

Chreoathetosis And Congenital Hypothyroidism With Or Without Pulmonary Dysfunction

Thyroid Cancer, Nonmedullary, 1

Papillary Thyroid Carcinoma

Familial Nonmedullary Thyroid Cancer, Papillary

Nonmedullary Thyroid Carcinoma, Papillary

Papillary Thyroid Cancer

NMTC1

Papillary Carcinoma Of Thyroid

Pact

Thyroid Carcinoma, Papillary

Non-Medullary Thyroid Carcinoma

Thyroid Cancer, Non-Medullary, 1

Familial Non-Medullary Thyroid Cancer

Fnmtc

Nmtc

Nonmedullary Thyroid Carcinoma

Ptc

Tpc

Thyroid Papillary Carcinoma

Cancer, Thyroid, Nonmedullary

Cancer, Thyroid, Nonmedullary, Type 1

Thyroid Carcinoma, Nonmedullary 1

Familial Nonmedullary Thyroid Gland Carcinoma

Papillary Carcinoma, Diffuse Sclerosing, Thyroid Gland

Nkx2-1-Related Disorders

Nkx2-1-Related Disorder

Large Cell Carcinoma

Carcinoma, Large Cell

Carcinoma Large Cell

Papillary Adenocarcinoma

Infiltrating And Papillary Adenocarcinoma

Infiltrating Papillary Adenocarcinoma

Adenocarcinoma Papillary

Adenocarcinoma, Papillary

Hypothyroidism

Thyroid Diseases

Thyroid Disease

Thyroid Deficiency

Thyroid Insufficiency

Dysfunction Thyroid

Thyroid Dysfunction

Struma Ovarii
Pulmonary Sclerosing Hemangioma

Pneumocytoma

Carcinoid Tumors, Intestinal

Carcinoid

Gastrointestinal Carcinoid Tumor

Argentaffinoma

Intestinal Carcinoid Tumor

ICT

Tumor, Carcinoid, Intestinal

Malignant Carcinoid Syndrome

Carcinoid Tumor Of Intestine

Carcinoid Tumor

Carcinoid Tumor No Icd-O Subtype

Lung Benign Neoplasm

Lung Neoplasms

Tumor Of The Lung

Lung Tumor

Bronchiolo-Alveolar Adenocarcinoma

Bronchioloalveolar Carcinoma

Bronchioalveolar Lung Carcinoma

Minimally Invasive Lung Adenocarcinoma

Carcinoma Bronchioloalveolar

Adenocarcinoma, Bronchiolo-Alveolar

Bronchioloalveolar Adenocarcinoma

Sclerosing Hemangioma

Sclerosing Haemangioma

Cutaneous Fibrous Histiocytoma

Pulmonary Blastoma

Blastoma Of Lung

Pneumoblastoma

Congenital Hypothyroidism

Cretinism

Neonatal Hypothyroidism

Ch

Cht

Congenital Myxedema

Myxedema, Congenital

Endemic Cretinism

Congenital Iodine-Deficiency Syndrome

Fetal Iodine Deficiency Syndrome

Congenital Iodine-Deficiency Hypothyroidism Nos

Merkel Cell Carcinoma

Trabecular Adenocarcinoma

Cutaneous Neuroendocrine Carcinoma

Trabecular Carcinoma

Carcinoma, Merkel Cell

Merkel Cell Cancer

Merkle Tumors

Mcc

Carcinoma Merkel Cell

Blastoma

Embryoma

Thymus Cancer

Thymic Neoplasm

Thymic Tumor

Thymus Neoplasm

Thymus Neoplasms

Malignant Neoplasm Of Thymus

Neoplasm Of Thymus

Thymic Neoplasms

Thymoma, Familial

Thymic Carcinoma

Thymoma, Type C

Cancer Of Thymus

Malignant Tumour Of Thymus

Primary Malignant Neoplasm Of Thymus

Thymic Glandular Cancer

Thymus Gland Cancer

Neuroendocrine Carcinoma

Neuroendocrine Cancer

Carcinoma Neuroendocrine

Carcinoma, Neuroendocrine

Papillary Carcinoma

Carcinoma, Papillary

Carcinoma Papillary

Athyreosis
Thymic Carcinoma

Malignant Thymoma

Thymoma, Malignant

Athetosis
Thyroid Gland Cancer

Thyroid Gland Carcinoma

Malignant Neoplasm Of Thyroid Gland

Malignant Tumour Of Thyroid Gland

Thyroid Neoplasm

Thyroid Neoplasms

Neoplasm Of Thyroid Gland

Thyroid Gland Neoplasm

Head And Neck Cancer, Thyroid

Neoplasm Of The Thyroid Gland

Cancer Of The Thyroid

Primary Malignant Neoplasm Of Thyroglossal Duct

Malignant Neoplasm Of Thyroglossal Duct

Primary Malignant Neoplasm Of Thyroid Gland

Thyroglossal Duct Cancer

Toxic Goitre Malignant Tumour

Cancerous Goitre

Posterior Pituitary Gland Neoplasm

Posterior Pituitary Tumor

Neoplasm Of The Posterior Pituitary

Bronchial Mucus Gland Adenoma

Adenoma Of Bronchial Mucus Gland

Adenoma Of The Bronchial Mucus Gland

Bronchial Benign Neoplasm

Bronchus Neoplasm

Neoplasm Of Bronchus

Bronchial Neoplasms

Bronchial Neoplasm

Hemangioma

Hemangiomas

Alveoli Adenoma

Alveolar Adenoma

Adenoma Of Alveoli

Adenoma Of The Alveoli

Goiter

Goitre

Trachea Carcinoma

Pancoast Tumor

Carcinoma Of The Trachea

Pancoast'S Tumor

Malignant Superior Sulcus Tumor

Malignant Superior Sulcus Tumour

Pancoast Tumour

Pancoast'S Syndrome

Pancoast'S Tumour

Pulmonary Sulcus Tumor

Pulmonary Sulcus Tumour

Superior Pulmonary Sulcus Syndrome

Pancoast Syndrome

Intestinal Perforation

Perforation Of Intestine

Neurohypophysis Granular Cell Tumor

Granular Cell Tumor Of The Neurohypophysis

Mucinous Bronchioloalveolar Adenocarcinoma

Bronchiolo-Alveolar Carcinoma, Mucinous

Pleomorphic Carcinoma
Thyroid Gland Anaplastic Carcinoma

Anaplastic Thyroid Carcinoma

Anaplastic Thyroid Cancer

Thyroid Cancer, Anaplastic

Thyroid Carcinoma, Anaplastic

Thyroid Carcinoma Anaplastic

Ovarian Germ Cell Teratoma

Germ Cell Teratoma Of Ovary

Ovarian Teratoma

Differentiated Thyroid Carcinoma

Papillary Or Follicular Thyroid Carcinoma

Well-Differentiated Thyroid Carcinoma

Differentiated Thyroid Gland Carcinoma

Frontal Sinus Cancer

Malignant Neoplasm Of Frontal Sinus

Malignant Tumor Of Frontal Sinus

Malignant Tumor Of The Frontal Sinus

Neoplasm Of Frontal Sinus

Frontal Sinus Squamous Cell Carcinoma

Epidermoid Carcinoma Of The Frontal Sinus

Lung Cancer

Lung Carcinoma

Non-Small Cell Lung Carcinoma

Lung Cancer, Susceptibility To

Lung Cancer, Protection Against

Adenocarcinoma Of Lung, Somatic

Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer

Lung Neoplasm

Carcinoma Of Lung

Lung Non-Small Cell Carcinoma

Non-Small Cell Lung Cancer

Nsclc

Lung Neoplasms

Malignant Neoplasm Of Lung

Alveolar Cell Carcinoma

Nonsmall Cell Lung Cancer, Somatic

Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer, Susceptibility To

Lung Cancer, Somatic

Lung Cancer, Resistance To

Cancer Of Lung

Cancer Of Bronchus

Cancer Of The Lung

Lung Malignancies

Lung Malignant Tumors

Malignant Lung Tumor

Malignant Tumor Of Lung

Pulmonary Cancer

Pulmonary Carcinoma

Pulmonary Neoplasms

Respiratory Carcinoma

LNCR

Adenocarcinoma Of Lung

Neoplasm Of Lung

Cancer Lung

Carcinoma Non-Small Cell Lung

Carcinoma, Non-Small-Cell Lung

Lung Cancers

Lung Carcinomas

Cancer, Lung

Cancer, Lung, Non-Small Cell

Primary Malignant Neoplasm Of Lung

Bronchioloalveolar Adenocarcinoma

Thyroglossal Duct Cyst, Familial

Familial Thyroglossal Duct Cyst

Thyroglossal Duct Cyst

Hereditary Thyroglossal Duct Cysts

Thyroglossal Duct Cysts

Thyroglossal Duct Cysts Familial

Thyroglossal Cyst

Plasma Cell Neoplasm

Plasma Cell Dyscrasia

Paraproteinemias

Plasma Cell Tumour

Plasmacytic Tumor

Multiple Myeloma

Plasmacytoma

Plasma Cell Tumours

Plasma Cells Dyscrasia

Mucinous Lung Adenocarcinoma
Papillary Thyroid Microcarcinoma
Adenosquamous Carcinoma

Adenosquamous Cell Carcinoma

Mixed Adenocarcinoma And Squamous Carcinoma

Carcinoma Adenosquamous

Carcinoma, Adenosquamous

Larynx Sarcoma

Sarcoma Of Larynx

Laryngeal Sarcoma

Benign Mesothelioma

Mesothelioma

Benign Tumor Of Mesothelium

Adenomatoid Tumor

Pneumothorax

Pneumothorax Nos

Air Leak Nos

Pleural Air Leak Nos

Respiratory Failure

Acute Respiratory Failure

Chronic Respiratory Failure

Respiratory Insufficiency

Acute-On-Chronic Respiratory Failure

Respiratory Disease

Acute And Chronic Respiratory Failure

Respiratory Insufficiency/Failure

Chronic Respiratory Disease

Pulmonary Valve Insufficiency

Chronic Disease Of Respiratory System

Respiration Disorders

Respiratory Tract Diseases

Lung Failure Nos

Pulmonary Failure

Arf - [Acute Respiratory Failure]

Acute Respiratory Insufficiency

Acute Pulmonary Insufficiency

Acute Respiration Failure

Chronic Respiration Failure

Teratoma

Teratomas

Follicular Adenoma

Follicular Adenoma Of The Thyroid Gland

Thyroid Follicular Adenoma

Adenoma Follicular

Follicular Thyroid Adenoma

Thyroid Gland Follicular Adenoma

Adenomatoid Tumor

Adenomatoid Tumour

Benign Localised Epithelial Mesothelioma

Benign Localized Epithelial Mesothelioma

Granular Cell Tumor

Abrikosov'S Tumor

Neoplasm Of Granular Cell

Abrikosoff'S Granulous Cell Tumor

Abrikosoff'S Tumor

Giant Granulocellular Abrikosov'S Tumor

Malignant Variant Of Abrikosov'S Tumor

Carcinoma, Granular Cell

Thymoma

Primary Thymic Epithelial Neoplasm

Primary Thymic Epithelial Tumor

Thymus Neoplasms

Nonmucinous Bronchioloalveolar Adenocarcinoma
Mesothelioma, Malignant

Malignant Mesothelioma

Pleural Mesothelioma

MESOM

Mesothelioma, Somatic

Advanced Malignant Mesothelioma

Asbestos-Related Malignant Mesothelioma

Diffuse Malignant Mesothelioma

Malignant Tumor Of Mesothelium

Malignant Mesothelioma, Susceptibility To

Mesothelioma Diffuse Malignant

Mesothelioma

Malignant Pleural Mesothelioma

Third Ventricle Chordoid Glioma

Chordoid Glioma Of The Third Ventricle

Chordoid Glioma Of 3rd Ventricle

Chordoid Glioma Of Third Ventricle

Newborn Respiratory Distress Syndrome

Hyaline Membrane Disease

Respiratory Distress Syndrome Of Newborn

Neonatal Respiratory Distress

Hmd - Hyaline Membrane Disease

Neonatal Respiratory Distress Syndrome

Pulmonary Hyaline Membrane Disease

Pulmonary Hypoperfusion Syndrome Of Newborn

Respiratory Distress Syndrome, Newborn

Respiratory Distress Syndrome

Cardiorespiratory Distress Syndrome Of Newborn

Distress Respiratory Syndrome Newborn

Idiopathic Respiratory Distress Syndrome

Idiopathic Respiratory Distress Syndrome Of Newborn

Newborn Idiopathic Respiratory Distress Syndrome

Respiratory Distress Syndrome In Newborn

Rds - [Respiratory Distress Syndrome] Of Newborn

Newborn Cardiorespiratory Distress Syndrome

Papillary Adenoma

Glandular Papilloma

Adenoma

Small Cell Cancer Of The Lung

Small Cell Lung Cancer

Small Cell Lung Carcinoma

Sclc

Small-Cell Cancer Of Lung

Lung Small Cell Carcinoma

Sclc1

Sccl

Cancer, Lung, Small Cell

Small Cell Carcinoma Of Lung

Carcinoma, Small Cell

Respiratory System Benign Neoplasm
Myeloma, Multiple

Multiple Myeloma

Plasma Cell Myeloma

Kahler Disease

Myelomatosis

Medullary Plasmacytoma

Multiple Myeloma, Resistance To

Myeloma

Plasma Cell Dyscrasia

Kahler'S Disease

Multiple Myeloma, Susceptibility To

Myeloma - Multiple

Kahler-Bozzolo Disease

Plasma Cell Myelomas

MM

Plasma Cell Neoplasm

Primary Systemic Amyloidosis

Primary Amyloidosis

Immunoglobulin Deposition Disease

Plasmacytic Myeloma

Multiple Myelomata

Multiple Myeloma Nos

Multiple Myeloma Without Mention Of Remission

Monostotic Plasma Cell Myeloma

Mm - [Multiple Myeloma]

Adenocarcinoma

Adenocarcinomas

Adenoacanthoma Of Unspecified Site

Adenocarcinoid Of Unspecified Site

Adenocarcinoid Tumour Of Unspecified Site

Adenocarcinoma And Carcinoid Combined Of Unspecified Site

Adenocarcinoma Nos

Lung Disease

Lung Diseases

Disorder Of Lung

Abnormality Of The Lung

Large Cell Neuroendocrine Carcinoma
Hypothyroidism, Congenital, Nongoitrous, 2

Thyroid Dysgenesis

CHNG2

Thyroid Hypoplasia

Thyroid Hemiagenesis

Thyroid Agenesis

Athyreotic Hypothyroidism

Rtsh

Thyrotropin Resistance

Hypothyroidism, Congenital, Due To Thyroid Dysgenesis Or Hypoplasia

Congenital Nongoitrous Hypothyroidism 2

Thyroid, Ectopic

Hypothyroidism, Congenital, Due To Thyroid Dysgenesis

Hypothyroidism, Athyreotic

Thyrotropin

Resistance To Thyrotropin

Congenital Hypothyroidism Due To Thyroid Dysgenesis Or Hypoplasia

Hypothyroidism, Congenital, Non-Goitrous, 2

Congenital Hypothyroidism Due To Thyroid Dysgenesis

Thyroid-Stimulating Hormone Resistance

Thyroid Ectopic

Ectopic Thyroid

Hypothyroidism, Congenital, Nongoitrous, 3

Thyroid Hormone Resistance Syndrome

Hypothyroidism, Congenital, Nongoitrous, 1

Bronchus Adenoma

Bronchial Adenoma

Adenoma Of The Bronchus

Lung Large Cell Carcinoma

Large Cell Carcinoma Of Lung

Large Cell Lung Carcinoma

Large Cell Lung Cancer

Diaphragmatic Hernia, Congenital

Congenital Diaphragmatic Hernia

Diaphragmatic Hernia

Cdh

Congenital Diaphragmatic Defect

Hernia, Diaphragmatic

Dih

Hernia, Congenital Diaphragmatic

Hcd

Diaphragmatic Defect, Congenital

Diaphragm, Unilateral Agenesis Of

Hemidiaphragm, Agenesis Of

Diaphragmatic Hernia 1

Agenesis Of Hemidiaphragm

Unilateral Agenesis Of Diaphragm

Hernia Diaphragmatic

Hernia Diaphragmatic Congenital

Hernia, Diaphragmatic, Type 1

Hiatus Hernia

Oesophageal Hiatus Hernia

Paraoesophageal Hernia

Sliding Hiatus Hernia

Congenital Diaphragm Hernia

Congenital Diaphragm Defect With Hernia

Gross Congenital Diaphragm Defect

Benign Teratoma

Dermoid Cyst

Cystic Dermoid Choristoma

Dermoid Choristoma

Mature Cystic Teratoma

Dermoid Tumour

Teratoma, Benign

Dermoid Cyst Of Ovary

Neonatal Respiratory Failure

Respiratory Failure Of Newborn

Inadequate Pulmonary Ventilation Of Newborn

Newborn Lung Insufficiency

Newborn Pulmonary Function Inadequate

Newborn Pulmonary Insufficiency

Newborn Respiration Failure

Newborn Respiratory Insufficiency

Respiratory Insufficiency Syndrome Of Newborn

Neuroendocrine Tumor

Neuroendocrine Neoplasm

Neuroendocrine Tumors

Carcinoma, Neuroendocrine

Thyroid Malformation
Solid Adenocarcinoma With Mucin Production
Sex Cord-Gonadal Stromal Tumor

Sex Cord-Gonadal Stromal Tumour

Sex Cord Stromal Tumour

Sex Cord-Stromal Neoplasm

Specialized Gonadal Neoplasm

Specialized Gonadal Tumor

Specialized Gonadal Tumour

Sex Cord-Gonadal Stromal Tumors

Sex Cord-Stromal Tumor

Malignant Testicular Sex Cord-Stromal Tumor

Sex Cord Stromal Tumor Of Testis

Sternum Cancer

Malignant Sternal Neoplasm

Neoplasm Of Sternum

Sternum Lymphoma

Lymphoma Of Sternum

Lymphoma Of The Sternum

Lung Meningioma

Lung Primary Meningioma

Primary Pulmonary Meningioma

Pulmonary Meningioma

Primary Lung Meningioma

Malignant Struma Ovarii

Struma Ovarii, Malignant

Lung Papillary Adenocarcinoma

Papillary Lung Adenocarcinoma

Papillary Adenocarcinoma Of The Lung

Thyroid Carcinoma, Familial Medullary

Medullary Thyroid Carcinoma

Familial Medullary Thyroid Carcinoma

MTC

Medullary Thyroid Cancer

Fmtc

Mtc1

Thyroid Cancer, Medullary

Thyroid Carcinoma, Medullary

Familial Mtc

Thyroid Carcinoma Medullary

Carcinoma, Thyroid, Medullary, Familial

Medullary Carcinoma Of Thyroid

Medullary Carcinoma With Amyloid Stroma, Unspecified Site

Medullary Carcinoma With Amyloid Stroma Of Thyroid

Keratinizing Squamous Cell Carcinoma

Squamous Cell Carcinoma, Keratinizing

Keratinizing Epidermoid Carcinoma

Ovarian Germ Cell Cancer

Ovarian Germ Cell Tumor

Malignant Germ Cell Tumor Of Ovary

Germ Cell Neoplasm Of Ovary

Germ Cell Tumor Of Ovary

Mogct

Malignant Ovarian Germ Cell Tumor

Malignant Ovarian Germ Cell Neoplasm

Lung Sarcomatoid Carcinoma

Sarcomatoid Carcinoma Of The Lung

Pulmonary Sarcomatoid Carcinoma

Patent Foramen Ovale

Atrial Septal Defect Within Oval Fossa

Foramen Ovale Patent

Ostium Secundum Atrial Septal Defect

Atrial Septal Defect, Ostium Secundum Type

Foramen Ovale, Patent

Defect, Patent Or Persistent, Ostium Secundum

Ostium Secundum Type Atrial Septal Defect

Persistent Ostium Secundum

Asd Ostium Secundum Type

Ostium Secundum Asd

Osasd

Asd, Ostium Secundum Type

Pfo - [Patent Foramen Ovale]

Open Foramen Ovale

Open Oval Foramen

Persistent Foramen Ovale

Secundum Atrial Septal Defect

Chordoid Glioma

Chordoid Glioma Of The Third Ventricle

Paraganglioma

Chemodectoma

Glomus Body Tumor

Paragangliomas

Carotid Body Paraganglioma

Extra-Adrenal Paraganglioma

Dystonia

Dystonic Disease

Dystonic Disorder

Dystonia Disorders

Neuroleptic Dyskinesia

Spindle Epithelial Tumor With Thymus-Like Differentiation Tumor

Settle Tumor

Settle Tumour

Spindle Epithelial Tumour With Thymus-Like Differentiation Tumour

Lung Acinar Adenocarcinoma

Acinar Adenocarcinoma Of The Lung

Small Cell Carcinoma

Small Cell Carcinoma, Intermediate Cell

Intermediate Cell Small Cell Carcinoma

Small Cell Carcinoma - Intermediate Cell

Small Cell Carcinoma Of Lung

Carcinoma, Small Cell

Main Bronchus Cancer

Malignant Neoplasm Of Main Bronchus

Ca Main Bronchus

Lung Giant Cell Carcinoma

Carcinoma, Giant Cell

Giant Cell Carcinoma

Giant Cell Lung Carcinoma

Carcinoma Giant Cell

Giant Cell Carcinoma Of Lung

Mucinous Adenocarcinoma

Mucin-Producing Adenocarcinoma

Mucin-Secreting Adenocarcinoma

Mucin-Secreting Carcinoma

Mucous Carcinoma

Pseudomyxoma Peritonei With Unknown Primary Site

Adenocarcinoma, Mucinous

Ureter Small Cell Carcinoma

Ureteral Small Cell Carcinoma

Salivary Gland Carcinoma

Salivary Gland Cancer

Malignant Neoplasm Of Salivary Gland

Salivary Gland Neoplasms

Pulmonary Neuroendocrine Tumor

Neuroendocrine Neoplasm Of Lung

Lung Carcinoma In Situ
Pulmonary Large Cell Neuroendocrine Carcinoma

Large Cell Lung Neuroendocrine Carcinoma

Lung Cancer Susceptibility 3

Lung Adenocarcinoma

Adenocarcinoma Of Lung

LNCR3

Adenocarcinoma Of Lung, Susceptibility To

Bronchogenic Lung Adenocarcinoma

Nonsmall Cell Adenocarcinoma

Adenocarcinoma Lung

Lung Adenocarcinomas

Non-Small Cell Adenocarcinoma

Thymus Basaloid Carcinoma

Basaloid Carcinoma Of The Thymus

Thymic Basaloid Carcinoma

Squamous Cell Carcinoma

Epidermoid Carcinoma

Squamous Cell Cancer

Carcinoma, Squamous Cell

Squamous Cell Skin Cancer

Malignant Squamous Cell Tumor

Squamous Carcinoma

Squamous Cell Epithelioma

Carcinoma Squamous Cell

Neoplasms, Squamous Cell

Squamous Cell Carcinoma - Category

Malignant Squamous Cell Neoplasm

Squamous Cell Carcinoma Of Skin

Aortic Malignant Tumor

Aortic Malignant Neoplasm

Malignant Aortic Neoplasm

Thymus Clear Cell Carcinoma

Clear Cell Carcinoma Of The Thymus

Thymic Clear Cell Carcinoma

Glioblastoma Neural Subtype
Movement Disease

Movement Disorders

Movement Disorder

Ureter Adenocarcinoma

Adenocarcinoma Of Ureter

Ureteral Adenocarcinoma

Adenocarcinoma In Situ
Choreatic Disease

Chorea

Hereditary Chorea

Nasal Cavity Olfactory Neuroblastoma

Olfactory Neuroblastoma Of The Nasal Cavity

Hypothyroidism, Thyroidal Or Athyroidal, With Spiky Hair And Cleft Palate

Bamforth-Lazarus Syndrome

Bamforth Syndrome

Hypothyroidism, Athyroidal, With Spiky Hair And Cleft Palate

Hypothyroidism Cleft Palate Hypothyroidism, Athyroidal, With Spiky Hair And Cleft Palate

Athyroidal Hypothyroidism-Spiky Hair-Cleft Palate Syndrome

Hypothyroidism-Cleft Palate Syndrome

BLS

Athyroidal Hypothyroidism With Spiky Hair And Cleft Palate

Tracheal Disease

Tracheal Diseases

Tracheal Anomaly

Tracheal Disorders

Tall Cell Variant Papillary Carcinoma

Tall Cell Variant Thyroid Gland Papillary Carcinoma

Basaloid Squamous Cell Carcinoma

Basaloid Carcinoma

Thyroid Gland Follicular Carcinoma

Follicular Thyroid Carcinoma

Follicular Adenocarcinoma

Follicular Adenocarcinoma, Well Differentiated

Follicular Carcinoma

Thyroid Adenocarcinoma

Adenocarcinoma, Follicular

Tracheomalacia

Congenital Tracheomalacia

Congenital Major Airway Collapse

Tracheomalacia, Congenital

Type 1 Tracheomalacia

Pulmonary Adenocarcinoma In Situ

Bronchioalveolar Carcinoma

Cystic Teratoma

Dermoid Cyst

Benign Teratoma

Lymphangitis

Inflammation Of Lymphatics

Multinodular Goiter
Ectopic Thymus
Interstitial Lung Disease

Ild

Lung Diseases, Interstitial

Lung Diseases Interstitial

Interstitial Lung Diseases

Thyroid Dyshormonogenesis 2a

TDH2A

Iodide Peroxidase Deficiency

Deficiency Of Iodide Peroxidase

Thyroid Peroxidase Deficiency

Genetic Defect In Thyroid Hormonogenesis 2a

Thyroid Hormonogenesis, Genetic Defect In, 2a

Hypothyroidism, Congenital, Due To Dyshormonogenesis, 2a

Chdh2a

Congenital Hypothyroidism Due To Dyshormonogenesis Type 2a

Thyroid Hormone Organification Defect 2

Tiod

Ovarian Cystic Teratoma
Thyroid Gland Disease

Abnormality Of The Thyroid Gland

Thyroid Diseases

Restless Legs Syndrome

Wed

Willis-Ekbom Disease

Restless Leg Syndrome

Ekbom Syndrome

Wittmaack-Ekbom Syndrome

Willis Ekbom Disease

Ekbom'S Syndrome

Rls

Restless Legs

Restless Legs Syndrome, Susceptibility To

Ovary Leiomyosarcoma

Leiomyosarcoma Of Ovary

Mediastinal Cancer

Mediastinal Neoplasms

Mediastinal Tumor

Mediastinum Cancer

Neoplasm Of Mediastinum

Tumour Of Mediastinum

Malignant Tumor Of Mediastinum

Tracheal Stenosis

Stenosis Of Trachea

Carotid Body Cancer

Cancer Of Carotid Body

Malignant Carotid Body Paraganglioma

Malignant Carotid Body Tumor

Malignant Neoplasm Of Carotid Body

Laryngeal Small Cell Carcinoma

Small Cell Carcinoma Of Larynx

Thyroid Gland Medullary Carcinoma

Medullary Thyroid Carcinoma

Medullary Carcinoma Of The Thyroid Gland

Ultimobranchial Thyroid Tumor

Ultimobranchial Thyroid Tumour

Thyroid Cancer, Medullary

Cerebral Palsy

Infantile Cerebral Palsy

Mixed Cerebral Palsy

Palsy Cerebral

Palsy, Cerebral

Cerebral Palsy, Mixed

Laryngeal Neuroendocrine Tumor

Laryngeal Neuroendocrine Tumour

Neuroendocrine Tumor Of Larynx

Neuroendocrine Tumour Of Larynx

Neuroendocrine Neoplasm Of Larynx

Retinal Melanoma

Malignant Retinal Melanoma

Malignant Melanoma Of Retina

Renal Cell Carcinoma, Nonpapillary

Renal Cell Carcinoma

RCC

Nonpapillary Renal Cell Carcinoma

Clear Cell Renal Cell Carcinoma

Hypernephroma

Adenocarcinoma Of Kidney

Renal Carcinoma, Chromophobe, Somatic

Clear Cell Carcinoma Of Kidney

Clear-Cell Metastatic Renal Cell Carcinoma

Clear Cell Renal Carcinoma

Renal Cell Carcinoma, Somatic

Conventional Renal Cell Carcinoma

Conventional Renal Cell Carcinoma

Renal Clear Cell Carcinoma

Ccrcc

Hereditary Clear Cell Renal Cell Carcinoma

Carcinoma, Renal Cell

Renal Cell Carcinoma, Clear Cell, Somatic

Renal Cell Carcinoma, Clear Cell

Clear Cell Kidney Carcinoma

Clear Cell Rcc

Cystic-Multilocular Variant

Clear Cell Renal Cell Adenocarcinoma

Hereditary Clear Cell Renal Cell Adenocarcinoma

Common Renal Cell Carcinoma

Crcc

Renal Cell Carcinoma Non-Papillary

Carcinoma Renal Cell

Renal Cell Cancer

Carcinoma, Renal Cell, Nonpapillary

Lung Clear Cell Carcinoma
Lung Adenoma

Adenoma Of Lung

Pulmonary Adenoma

Mixed Lacrimal Gland Cancer

Carcinoma Ex Pleomorphic Adenoma Of Lacrimal Gland

Carcinoma Ex Pleomorphic Adenoma Of The Lacrimal Gland

Malignant Mixed Neoplasm Of Lacrimal Gland

Lymphohistiocytoid Mesothelioma
Mowat-Wilson Syndrome

MOWS

Microcephaly, Mental Retardation, And Distinct Facial Features, With Or Without Hirschsprung Disease

Hirschsprung Disease-Mental Retardation Syndrome

Mowat-Wilson Syndrome Due To Monosomy 2q22

Hirschsprung Disease Mental Retardation Syndrome

Microcephaly, Mental Retardation, And Distinct Facial Featrues, With Or Without Hirschprung Disease

Hirschsprung Disease - Intellectual Disability Syndrome

Hirschsprung Disease Intellectual Disability Syndrome

Intellectual Disability, Microcephaly, And Distinct Facial Features With Or Without Hirschsprung Disease

Mws

Hirschsprung Disease-Intellectual Disability Syndrome

Hirschsprung Disease And Intellectual Disability Due To 2q22 Microdeletion

Hirschsprung Disease And Intellectual Disability Due To Del(2)(Q22)

Hirschsprung Disease And Intellectual Disability Due To Monosomy 2q22

Mowat-Wilson Syndrome Due To 2q22 Microdeletion

Mowat-Wilson Syndrome Due To Del(2)Q(22)

Mowat-Wilson Syndrome Due To A Zeb2 Point Mutation

Hirschsprung Disease And Intellectual Disability Due To A Zeb2 Point Mutation

Colorectal Cancer

Colon Cancer

Colorectal Carcinoma

Colon Carcinoma

Colorectal Cancer, Susceptibility To

Carcinoma Of Colon

CRC

Colorectal Cancer With Chromosomal Instability, Somatic

Colon Cancer, Somatic

Colon Cancer, Susceptibility To

Colonic Neoplasms

Colorectal Neoplasms

Colorectal Cancer, Somatic

Colon Cancer, Advanced, Somatic

Colonic Carcinoma

Colorectal Carcinomas

Colon Cancers

Colorectal Cancers

Cancer, Colorectal, Somatic

Cancer, Colon

Cancer, Colorectal, Susceptibility To

Colorectal Neoplasm

Colonic Neoplasm

Malignant Tumor Of Colon

Esophageal Atresia

Tracheoesophageal Fistula

Congenital Atresia Of Esophagus

Congenital Imperforate Esophagus

Imperforate Esophagus

Oesophageal Atresia

Te Fistula

Tef

Tracheoesophageal Fistula With Or Without Esophageal Atresia

Breast Cancer

Breast Carcinoma

Male Breast Cancer

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation

Hirschsprung Disease 1

Hirschsprung Disease

Aganglionic Megacolon

Hscr

Hirschsprung'S Disease

Congenital Megacolon

Congenital Intestinal Aganglionosis

Colonic Aganglionosis

Hirschsprung Disease, Susceptibility To, 1

Hirschsprung Disease, Protection Against

HSCR1

Mgc

Pelvirectal Achalasia

Total Intestinal Aganglionosis

Megacolon, Aganglionic

Macrocolon

Hscr 1

Hirschsprung Disease Type 1

Hirschsprung Disease, Type 1

Congenital Dilatation Of Colon

Aganglionosis

Congenital Aganglionic Megacolon

Aganglionosis Of Colon

Bowel Aganglionosis

Colon Aganglionosis

Hirschsprung Megacolon

Wilms Tumor 1

Nephroblastoma

Wilms Tumor

WT1

Wilms' Tumor

Bilateral Wilms Tumor

Wilms Tumor, Type 1

Wilms Tumor, Somatic

Adult Nephroblastoma

Wt1 Disorder

Renal Embryonic Tumor

Adult Kidney Wilms Tumor

Childhood Kidney Wilms Tumor

Nonanaplastic Kidney Wilms Tumor

Congenital Nervous System Abnormality

Congenital Neurologic Anomaly

Congenital Nervous System Disorder

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Mus musculus NKX2-1 MGD MGI:108067
Rattus norvegicus NKX2-1 RGD RGD:3866
Bos taurus NKX2-1 VGNC VGNC:49980
Macaca mulatta NKX2-1 VGNC VGNC:84409
Felis catus NKX2-1 VGNC VGNC:80906