1. Gene
  2. Scn2b - sodium channel, voltage-gated, type II, beta Gene

Scn2b - sodium channel, voltage-gated, type II, beta Gene

种属: Mus musculus

同用名: Gm183; 2810451E09Rik

基因 ID: 72821 | 基因类型: protein coding

关于 Scn2b

功能概要

Predicted to enable Sodium Channel regulator activity and voltage-gated Sodium Channel activity involved in cardiac muscle cell action potential. Predicted to be involved in several processes, including cardiac muscle cell action potential; regulation of atrial cardiac muscle cell membrane depolarization; and regulation of heart rate by cardiac conduction. Predicted to act upstream of or within regulation of ion transmembrane transport and sodium ion transport. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be part of voltage-gated Sodium Channel complex. Predicted to be active in plasma membrane. Is expressed in several structures, including cranial ganglion and dorsal root ganglion. Human ortholog(s) of this gene implicated in familial atrial fibrillation. Orthologous to human SCN2B (sodium voltage-gated channel beta subunit 2). [provided by Alliance of Genome Resources, Apr 2022]

Scn2b 基因产物(1)

mRNA Protein Name
NM_001014761.2 NP_001014761.1 sodium channel subunit beta-2 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within positive effect cardiac conduction IMP
IMP: 通过突变表型推断
27932425 MGI
acts upstream of or within positive effect gene expression IMP
IMP: 通过突变表型推断
16870743 MGI
acts upstream of or within response to heat IMP
IMP: 通过突变表型推断
16870743 MGI
acts upstream of or within sodium ion transport IMP
IMP: 通过突变表型推断
16870743 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
is active in T-tubule IDA
IDA: 通过直接分析推断
27932425 MGI
located in T-tubule IDA
IDA: 通过直接分析推断
27932425 MGI
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断
蛋白主名 其他名称

sodium channel subunit beta-2

sodium channel, voltage-gated, type II, beta polypeptide

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Scn2b NCBI NCBI:6327