CA11 - carbonic anhydrase 11 Gene

中文名称：碳酸酐酶 11

种属: Homo sapiens

同用名: CA-RP; CA-XI; CARP-2; CARPX1; CA-RP II

关于 CA11

功能概要

碳酸酐酶 (CA) 是一大类锌金属酶，可催化二氧化碳的可逆水合。它们参与多种生物过程，包括呼吸、钙化、酸碱平衡、骨吸收以及房水、脑脊液、唾液和胃酸的形成。它们在组织分布和亚细胞定位方面表现出广泛的多样性。 CA XI 可能是一种分泌蛋白，然而，在具有催化活性的 CA 同工酶中完全保守的活性位点残基发生根本变化，使其不太可能具有碳酸酐酶活性。它与其他两种非催化 CA 亚型 CA VIII 和 CA X 具有共同的特性。CA XI 在大脑中表达最丰富，并且可能在中枢神经系统中发挥一般作用。[RefSeq 提供，2008 年 7 月]

Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. CA XI is likely a secreted protein, however, radical changes at active site residues completely conserved in CA isozymes with catalytic activity, make it unlikely that it has Carbonic Anhydrase activity. It shares properties in common with two Other acatalytic CA isoforms, CA VIII and CA X. CA XI is most abundantly expressed in brain, and may play a general role in the central nervous system. [provided by RefSeq, Jul 2008]