2. Gene
  3. Notum - notum palmitoleoyl-protein carboxylesterase Gene

Notum - notum palmitoleoyl-protein carboxylesterase Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: 5730593N15Rik

基因 ID: 77583 | 基因类型: protein coding

关于 Notum

功能概要

Enables Lipase activity and palmitoleyl hydrolase activity. Involved in negative regulation of Wnt signaling pathway and protein depalmitoleylation. Acts upstream of or within bone development; negative regulation of canonical Wnt signaling pathway; and regulation of bone mineralization. Predicted to be located in extracellular region. Is expressed in several structures, including genitourinary system; heart valve; respiratory system; sensory organ; and vibrissa. Orthologous to human NOTUM (notum, palmitoleoyl-protein carboxylesterase). [provided by Alliance of Genome Resources, Apr 2022]

Notum 基因产物(3)

mRNA Protein Name
NM_001382269.1 NP_001369198.1 palmitoleoyl-protein carboxylesterase NOTUM isoform 1 precursor
NM_001382270.1 NP_001369199.1 palmitoleoyl-protein carboxylesterase NOTUM isoform 2 precursor
NM_175263.4 NP_780472.3 palmitoleoyl-protein carboxylesterase NOTUM isoform 1 precursor
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables lipase activity IDA
IDA: 通过直接分析推断
30622831 MGI
enables palmitoleyl hydrolase activity IDA
IDA: 通过直接分析推断
25771893 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
NOT involved in GPI anchor release IDA
IDA: 通过直接分析推断
25771893 MGI
acts upstream of or within bone development IMP
IMP: 通过突变表型推断
30622831 MGI
involved in negative regulation of Wnt signaling pathway IDA
IDA: 通过直接分析推断
25771893 MGI
acts upstream of or within negative regulation of canonical Wnt signaling pathway IDA
IDA: 通过直接分析推断
30622831 MGI
involved in protein depalmitoleylation IDA
IDA: 通过直接分析推断
25771893 MGI
acts upstream of or within regulation of bone mineralization IDA
IDA: 通过直接分析推断
30622831 MGI
acts upstream of or within regulation of bone mineralization IMP
IMP: 通过突变表型推断
30622831 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

palmitoleoyl-protein carboxylesterase NOTUM

notum pectinacetylesterase homolog

protein notum homolog

相关产品

Pre-clinical Phase
生物活性分子 (11)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-131034 LP-922056 Activator 99.63% 否
HY-122832 ABC99 Inhibitor 98.48% 否
HY-147519 ARUK3001185 Activator 99.28% 否
HY-142689 Carboxylesterase-IN-3 Inhibitor 98.27% 否
HY-142688 Carboxylesterase-IN-2 Inhibitor 99.91% 否
HY-149818 8BTC Inhibitor / 否
HY-RS09454 NOTUM Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-W171983 Notum-IN-1 Inhibitor / 否
HY-148360 Notum pectinacetylesterase-1 Inhibitor / 否
HY-RS21001 Notum Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS27518 Notum Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Notum NCBI NCBI:147111
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