DDX39B - DExD-box helicase 39B Gene

中文名称：DExD-box 解旋酶 39B

种属: Homo sapiens

同用名: BAT1; UAP56; D6S81E

基因 ID: 7919 | 基因类型: protein coding

关于 DDX39B

Cytogenetic location: 6p21.33 Genomic coordinates (GRCh38): 6:31,530,226-31,542,003 (from NCBI)

This gene has 21 transcripts (splice variants), 1 gene allele, 153 orthologues and 38 paralogues. Ubiquitous expression in endometrium (RPKM 76.9), ovary (RPKM 76.7) and 25 other tissues.

功能概要

该基因编码 RNA 依赖性 ATP 酶的 DEAD 盒家族成员，该家族在 pre-mRNA 剪接过程中介导 ATP 水解。编码的蛋白质是 U2 小核糖核蛋白与 pre-mRNA 结合所需的重要剪接因子，它还在 mRNA 从细胞核输出到细胞质中发挥重要作用。该基因属于位于编码肿瘤坏死因子α和肿瘤坏死因子β的基因附近的一组基因。这些基因都在人类主要组织相容性复合体 III 类区域内。该基因的突变可能与类风湿性关节炎有关。可变剪接导致多个转录本变体。已在 6 号和 11 号染色体上鉴定出相关的假基因。通读转录也发生在该基因和上游 ATP6V1G2 (ATP 酶、H+ 转运、溶酶体 13kDa、V1 亚基 G2) 基因之间。[RefSeq 提供，2011 年 2 月]

This gene encodes a member of the DEAD box family of RNA-dependent ATPases that mediate ATP hydrolysis during pre-mRNA splicing. The encoded protein is an essential splicing factor required for association of U2 small nuclear ribonucleoprotein with pre-mRNA, and it also plays an important role in mRNA export from the nucleus to the cytoplasm. This gene belongs to a cluster of genes localized in the vicinity of the genes encoding tumor necrosis factor alpha and tumor necrosis factor beta. These genes are all within the human major histocompatibility complex class III region. Mutations in this gene may be associated with rheumatoid arthritis. Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on both chromosomes 6 and 11. Read-through transcription also occurs between this gene and the upstream ATP6V1G2 (ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G2) gene. [provided by RefSeq, Feb 2011]

DDX39B 基因产物(2)

mRNA	Protein	Name
NM_004640.7	NP_004631.1	spliceosome RNA helicase DDX39B
NM_080598.6	NP_542165.1	spliceosome RNA helicase DDX39B

DDX39B 蛋白结构

DEAD

Helicase_C

0
100
200
300
400
428 a.a.

蛋白主名

其他名称

spliceosome RNA helicase DDX39B

56 kDa U2AF65-associated protein

DDX39B 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	DDX39B	Q13838	UBE2I	Homo sapiens	Q7KZS0	Validated Y2H	32296183
种属内	DDX39B	Q13838	UBE2I	Homo sapiens	Q7KZS0	Y2H Array	32296183
种属内	DDX39B	Q13838	UBE2I	Homo sapiens	Q7KZS0	Y2H Prey Pooling	32296183
种属内	DDX39B	Q13838	LUZP4	Homo sapiens	Q9P127	Y2H Array	32296183
种属内	DDX39B	Q13838	LUZP4	Homo sapiens	Q9P127	Y2H Prey Pooling	32296183
种属内	DDX39B	Q13838	LUZP4	Homo sapiens	Q9P127	Validated Y2H	32296183
种属内	DDX39B	Q13838	API5	Homo sapiens	Q9BZZ5	Anti Tag CoIP	35271311
种属内	DDX39B	Q13838	CHTOP	Homo sapiens	Q9Y3Y2-3	Y2H Prey Pooling	32296183
种属内	DDX39B	Q13838	CHTOP	Homo sapiens	Q9Y3Y2-3	Validated Y2H	32296183
种属内	DDX39B	Q13838	CHTOP	Homo sapiens	Q9Y3Y2-3	Y2H Array	32296183
种属内	DDX39B	Q13838	RNF4	Homo sapiens	P78317	Y2H Prey Pooling	32296183
种属内	DDX39B	Q13838	RNF4	Homo sapiens	P78317	Y2H Array	32296183
种属内	DDX39B	Q13838	SARNP	Homo sapiens	P82979	Y2H	14667819
种属内	DDX39B	Q13838	SARNP	Homo sapiens	P82979	Anti Tag CoIP	35271311
种属内	DDX39B	Q13838	ALYREF	Homo sapiens	Q86V81	Anti Tag CoIP	35271311
种属内	DDX39B	Q13838	ALYREF	Homo sapiens	Q86V81	Y2H	14667819
种属内	DDX39B	Q13838	ALYREF	Homo sapiens	Q86V81	Pull Down	11979277
种属内	DDX39B	Q13838	CHTOP	Homo sapiens	Q9Y3Y2	Y2H	14667819
种属内	DDX39B	Q13838	CHTOP	Homo sapiens	Q9Y3Y2	Crosslink	30021884
种属内	DDX39B	Q13838	CHTOP	Homo sapiens	Q9Y3Y2	Pull Down	23299939
种属内	DDX39B	Q13838	DDX39A	Homo sapiens	O00148	Y2H	14667819
种属内	DDX39B	Q13838	THOC1	Homo sapiens	Q96FV9	Anti Tag CoIP	35271311
种属内	DDX39B	Q13838	THOC1	Homo sapiens	Q96FV9	Pull Down	11979277
种属内	DDX39B	Q13838	SNRPA	Homo sapiens	P09012	Y2H Array	32296183
种属内	DDX39B	Q13838	SNRPA	Homo sapiens	P09012	Y2H Prey Pooling	32296183
种属内	DDX39B	Q13838	FYTTD1	Homo sapiens	Q96QD9	Anti Bait CoIP	21814512
种属内	DDX39B	Q13838	FYTTD1	Homo sapiens	Q96QD9	Anti Tag CoIP	35271311
种属内	DDX39B	Q13838	FYTTD1	Homo sapiens	Q96QD9	Pull Down	21814512

种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 DDX39B 蛋白

目录号	产品名	蛋白编号	纯度
HY-P71534	DDX39B Protein, Human (GST)	Q13838 (A2-V251)	≥95%

DDX39B 抗体

目录号	产品名	应用	反应物种
HY-P82725	DDX39B Antibody (YA2470)	WB, IHC-P, ICC/IF, FC	Human, Mouse, Rat

关联疾病

疾病名称

别名

Rheumatoid Arthritis

RA	Arthritis, Rheumatoid
Rheumatoid Arthritis, Susceptibility To	Arthritis Or Polyarthritis, Rheumatic
Atrophic Arthritis	Rheumatism Arthritis
Rheumatoid Polyarthritis

Autoimmune Disease

Autoimmune Diseases	Autoimmune Hypersensitivity Disease
Hypersensitivity Reaction Type Ii Disease	Type Ii Hypersensitivity Reaction Disease

Anterior Horn Cell Disease

Lethal Congenital Contracture Syndrome 1

LCCS1	Multiple Contracture Syndrome, Finnish Type
Lccs	Lethal Autosomal Recessive Syndrome Of Multiple Congenital Contractures
Lethal Congenital Contracture Syndrome Type 1	Herva Disease
Multiple Contracture Syndrome Finnish Type	Contracture Syndrome, Lethal, Congenital, Type 1

Malaria

Malaria, Susceptibility To	Malaria, Resistance To
Malaria, Cerebral	Cerebral Malaria
Malaria, Severe, Susceptibility To	Malaria, Severe, Resistance To
Malaria, Cerebral, Susceptibility To	Induced Malaria
Malaria, Vivax, Protection Against	Malaria, Severe
Malaria, Cerebral, Reduced Risk Of	Malaria, Protection Against
Resistance To Malaria Due To G6pd Deficiency	Malaria Due To G6pd Deficiency
Malarial Encephalitis	CM
Malaria Cerebral	Susceptibility To Malaria
Acute Pernicious Fever	Aestivo-Autumnal Fever
Aestivo Autumnal Malaria	Chagres Fever
Continued Malaria Fever	Estivo-Autumnal Fever
Estivo-Autumnal Malaria	Estivo-Autumnal Malarial Fever
Falciparum Fever	Malignant Tertian Fever
Malignant Tertian Malaria	Pernicious Intermittent Fever
Pernicious Malaria	Quotidian Malaria
Subtertian Fever	Subtertian Malaria Fever
Subtertian Malignant Tertian Malaria	Tropical Malaria
Algid Malaria	Bilious Haemoglobinuric Fever
Black Water Fever	Blackwater Fever
Malarial Blackwater Fever	Severe Malarial Falciparum
West African Fever	Malarial Haematinuria
Haemoglobinuric Fever	Haemoglobinuric Malaria
Severe Plasmodium Falciparum Malaria	Malarial Haemoglobinuria
Malarial Haematuria	Falciparum Malaria [Malignant Tertian]
Malaria Tropica	Malarial Shock
Chagres Virus Disease	Malignant Malaria
Mtm - [Malignant Tertian Malaria]	Tm -[Malignant Tertian Malaria]
Panama Fever	St - [Subtertian Malaria]
Malarial Quotidian	Benign Tertian Malaria
Tertian Ague	Vivax Fever
Plasmodium Vivax Malaria Nos	Btm - [Benign Tertian Malaria]
Bt - [Benign Tertian Malaria]	Vivax Malaria
Benign Tertian Vivax Malaria	Tertian Malaria
Quartan Malaria	Quartan Ague
Quartan Fever	Plasmodium Malariae Malaria Nos
Quartan Malarial	Malaria By Plasmodium Malariae
Malariae Malaria	Ovale Tertian Malaria
Plasmodium Ovale Fever	Malaria Fever By Plasmodium Ovale
Ovale Malaria	Malaria By Plasmodium Ovale
Malarial Ovale	Marsh Fever
Remittent Congestive Fever	Coastal Fever
Remittent Gastric Fever	Miasmatic Fever
Congestive Remittent Fever	Intermittent Fever
Jungle Fever	Paludism
Cameroon Fever	Ague
Corsican Fever	Intermittent Bilious Fever
Disease Due To Plasmodiidae	Malarial Fever
Plasmodiosis	Remittent Fever
Roman Fever	Malaria Fever Nos
Malaria Nos	Paludal Fever
Clinically Diagnosed Malaria	Clinically Diagnosed Malaria Without Parasitological Confirmation
Congestive Fever	Malarial Cachexia
Marsh Cachexia	Paludal Cachexia
Recurrent Malaria	Remittent Malaria

Systemic Lupus Erythematosus

Lupus Nephritis	SLE
Disseminated Lupus Erythematosus	Systemic Lupus Erythematosus, Susceptibility To
Lupus Erythematosus, Systemic	Lupus Nephritis, Susceptibility To
Libman-Sacks Disease	Systemic Lupus Erythematosus Susceptibility To
Sle - Lupus Erythematosus, Systemic	Le Syndrome
Lupus	Lupus Erythematosus Systemic
Lupus Erythematosus, Systemic, Susceptibility To	Lupus Vulgaris
Lupus Erythematosus, Discoid	Lupus Erythematosus
Systemic Lupus Erythematosus Nos	Sle - [Systemic Lupus Erythematosus]

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS03645	DDX39B Human Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS20544	Ddx39b Mouse Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS27052	Ddx39b Rat Pre-designed siRNA Set A	Pre-designed Set	/	否

直系同源

种属	基因名	来源	基因 ID
Macaca mulatta	DDX39B	VGNC	VGNC:71621
Bos taurus	DDX39B	VGNC	VGNC:27965
Felis catus	DDX39B	VGNC	VGNC:61407
Rattus norvegicus	DDX39B	RGD	RGD:70923
Canis familiaris	DDX39B	VGNC	VGNC:39855
Mus musculus	DDX39B	MGD	MGI:99240
Others	DDX39B	NCBI

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